Birth Defects Research Part A: Clinical and Molecular Teratology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

What is standing in the way of complete prevention of folate preventable neural tube defects?
(Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 14, 2016 Category: Perinatology & Neonatology Authors: James L. Mills, Aggeliki Dimopoulos, Regan L. Bailey Tags: Editorial Source Type: research

Issue Information
(Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 14, 2016 Category: Perinatology & Neonatology Tags: Issue Information Source Type: research

Cover Image
(Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 14, 2016 Category: Perinatology & Neonatology Tags: Cover Image Source Type: research

In utero exposure to venlafaxine, a serotonin –norepinephrine reuptake inhibitor, increases cardiac anomalies and alters placental and heart serotonin signaling in the rat
Birth Defects Research Part A: Clinical and Molecular Teratology,Volume 106, Issue 12, Page 1044-1055, December 2016. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 7, 2016 Category: Perinatology & Neonatology Authors: Laetitia Laurent, Chunwei Huang, Sheila R. Ernest, Anick Berard, Cathy Vaillancourt, Barbara F. Hales Source Type: research

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Birth Defects Research Part A: Clinical and Molecular Teratology,Volume 106, Issue 12, Page 1044-1055, December 2016. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 7, 2016 Category: Perinatology & Neonatology Source Type: research

Maternal gene –micronutrient interactions related to one‐carbon metabolism and the risk of myelomeningocele among offspring
ConclusionThere did not appear to be strong effects of maternal micronutrient intake on the role of maternal genetic polymorphisms in MTHFR C677T and A1298C on MM risk. Birth Defects Research (Part A), 2016. © 2016 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 6, 2016 Category: Perinatology & Neonatology Authors: Margaret P. Nguyen, Philip J. Lupo, Hope Northrup, Alanna C. Morrison, Paul T. Cirino, Kit Sing Au Tags: Original Research Article Source Type: research

In utero exposure to venlafaxine, a serotonin –norepinephrine reuptake inhibitor, increases cardiac anomalies and alters placental and heart serotonin signaling in the rat
ConclusionIn utero venlafaxine exposure altered the placental index and induced fetal cardiac anomalies in rats. We propose that the increased incidence of cardiac anomalies is mediated through alterations in serotonin signaling in the placenta and fetal heart. Birth Defects Research (Part A), 2016. © 2016 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 6, 2016 Category: Perinatology & Neonatology Authors: Laetitia Laurent, Chunwei Huang, Sheila R. Ernest, Anick Berard, Cathy Vaillancourt, Barbara F. Hales Tags: Original Research Article Source Type: research

Maternal gene–micronutrient interactions related to one‐carbon metabolism and the risk of myelomeningocele among offspring
ConclusionThere did not appear to be strong effects of maternal micronutrient intake on the role of maternal genetic polymorphisms in MTHFR C677T and A1298C on MM risk. Birth Defects Research (Part A), 2016. © 2016 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 6, 2016 Category: Perinatology & Neonatology Authors: Margaret P. Nguyen, Philip J. Lupo, Hope Northrup, Alanna C. Morrison, Paul T. Cirino, Kit Sing Au Tags: Original Research Article Source Type: research

Further evidence for deletions in 7p14.1 contributing to nonsyndromic cleft lip with or without cleft palate
CONCLUSIONThe present data support the hypothesis that deletions at 7p14 are a common risk factor for nsCL/P. Genome‐wide CNV analyses in nsCL/P cohorts are warranted to explore the functional relevance of these deletions and their contribution to nsCL/P, and to determine exact breakpoints.Birth Defects Research (Part A), 2016.© 2016 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - July 6, 2016 Category: Perinatology & Neonatology Authors: Johanna Klamt, Andrea Hofmann, Anne C. Böhmer, Ann‐Kathrin Hoebel, Lina Gölz, Jessica Becker, Alexander M. Zink, Markus Draaken, Alexander Hemprich, Martin Scheer, Gül Schmidt, Markus Martini, Michael Knapp, Elisabeth Mangold, Franziska Degenhardt, K Tags: Original Research Article Source Type: research

Congenital abnormalities in newborns of women with pregestational diabetes: A time ‐trend analysis, 1994 to 2009
ConclusionWhile the prevalence of birth defects among diabetic pregnancies is still considerably higher that nondiabetic pregnancies, results of the current study indicate a declining trend in the prevalence of some congenital abnormalities among babies born to both diabetic and nondiabetic mothers after 1999. We need to be more aggressive in implementing preventive measures, including a national diabetes plan or the proposed universal policy of supra‐dietary folic acid supplementation for women with diabetes who are of reproductive age.Birth Defects Research (Part A), 2016. © 2016 Wiley Periodicals, Inc. (Source: Birth...
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - June 30, 2016 Category: Perinatology & Neonatology Authors: Mohammad M. Agha, Richard H. Glazier, Rahim Moineddin, Gillian Booth Tags: Original Research Article Source Type: research

Environmental factors in the etiology of isolated and nonisolated esophageal atresia in a Chinese population: A case –control study
ConclusionThese results suggest a role for environmental exposures in the etiology of EA/TEF; however, further studies are needed to replicate the observed associations. Birth Defects Research (Part A), 2016. © 2016 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - June 30, 2016 Category: Perinatology & Neonatology Authors: Yu Feng, Runsen Chen, Xiaonan Li, Xuming Mo Tags: Original Research Source Type: research

Inhibition of the 3 ‐hydroxy‐3‐methyl‐glutaryl‐CoA reductase induces orofacial defects in zebrafish
ConclusionOur results suggest that HMGCR loss‐of‐function primarily affects postmigratory cranial neural crest cells through abnormal Sonic Hedgehog signaling, probably induced by reduction in metabolites of the cholesterol pathway. Malformation severity correlates with the grade of HMGCR inhibition, developmental stage of its disruption, and probably with availability of maternal lipids. Together, our results might help to understand the spectrum of orofacial phenotypes found in cholesterol synthesis disorders. Birth Defects Research (Part A), 2016. © 2016 Wiley Periodicals, Inc. (Source: Birth Defects Research Part ...
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - June 30, 2016 Category: Perinatology & Neonatology Authors: Iskra A. Signore, Carolina Jerez, Diego Figueroa, Jos é Suazo, Katherine Marcelain, Oscar Cerda, Alicia Colombo Flores Tags: Original Research Source Type: research

Effects of thyroxine exposure on the Twist 1 +/ − phenotype: A test of gene–environment interaction modeling for craniosynostosis
ConclusionOur findings suggest the phenotypic effects of the genetic mutation largely outweighed the effects of thyroxine exposure in the Twist 1 +/− model. These results highlight difficultly in experimentally modeling gene–environment interactions for craniosynostotic phenotypes.Birth Defects Research (Part A), 2016. © 2016 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - June 30, 2016 Category: Perinatology & Neonatology Authors: Emily L. Durham, R. Nicole Howie, Laurel Black, Grace Bennfors, Trish E. Parsons, Mohammed Elsalanty, Jack C. Yu, Seth M. Weinberg, James J. Cray Tags: Original Research Article Source Type: research

Effects of thyroxine exposure on the Twist 1 +/− phenotype: A test of gene–environment interaction modeling for craniosynostosis
ConclusionOur findings suggest the phenotypic effects of the genetic mutation largely outweighed the effects of thyroxine exposure in the Twist 1 +/− model. These results highlight difficultly in experimentally modeling gene–environment interactions for craniosynostotic phenotypes.Birth Defects Research (Part A), 2016. © 2016 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - June 30, 2016 Category: Perinatology & Neonatology Authors: Emily L. Durham, R. Nicole Howie, Laurel Black, Grace Bennfors, Trish E. Parsons, Mohammed Elsalanty, Jack C. Yu, Seth M. Weinberg, James J. Cray Tags: Original Research Article Source Type: research