Effects of thyroxine exposure on the Twist 1 +/− phenotype: A test of gene–environment interaction modeling for craniosynostosis

ConclusionOur findings suggest the phenotypic effects of the genetic mutation largely outweighed the effects of thyroxine exposure in the Twist 1 +/− model. These results highlight difficultly in experimentally modeling gene–environment interactions for craniosynostotic phenotypes.Birth Defects Research (Part A), 2016. © 2016 Wiley Periodicals, Inc.

Source: Birth Defects Research Part A: Clinical and Molecular Teratology - June 30, 2016 Category: Perinatology & Neonatology Authors: Emily L. Durham, R. Nicole Howie, Laurel Black, Grace Bennfors, Trish E. Parsons, Mohammed Elsalanty, Jack C. Yu, Seth M. Weinberg, James J. Cray Tags: Original Research Article Source Type: research