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Paternal and joint parental occupational pesticide exposure and spina bifida in the National Birth Defects Prevention Study, 1997 to 2002
ConclusionOverall, there was little evidence paternal occupational pesticide exposure was associated with spina bifida. However, the small numbers make it difficult to precisely evaluate the role of pesticide classes, individually and in combination. Birth Defects Research (Part A) 106:963–971, 2016. © 2016 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - November 27, 2016 Category: Perinatology & Neonatology Authors: Stacy M. Pettigrew, Erin M. Bell, Alissa R. Van Zutphen, Carissa M. Rocheleau, Gary M. Shaw, Paul A. Romitti, Andrew Olshan, Philip J. Lupo, Aida Soim, Jennifer A. Makelarski, Adrian M. Michalski, Wayne Sanderson, Tags: Research Article Source Type: research

Maternal autoimmune disease and birth defects in the National Birth Defects Prevention Study
ConclusionOur findings suggest maternal autoimmune disease and treatment are not associated with the majority of birth defects, but may be associated with some defects, particularly encephalocele. Given the low prevalence of individual autoimmune diseases and the rare use of specific medications, we were unable to examine associations of specific autoimmune diseases and medications with birth defects. Other studies are needed to confirm these findings. Birth Defects Research (Part A) 106:950–962, 2016. © 2016 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - November 27, 2016 Category: Perinatology & Neonatology Authors: Meredith M. Howley, Marilyn L. Browne, Alissa R. Van Zutphen, Sandra D. Richardson, Sarah J. Blossom, Cheryl S. Broussard, Suzan L. Carmichael, Charlotte M. Druschel, Tags: Research Article Source Type: research

Association between antibiotic use among pregnant women with urinary tract infections in the first trimester and birth defects, National Birth Defects Prevention Study 1997 to 2011
ConclusionPericonceptional exposure to some antibiotics might increase the risk for certain birth defects. However, because individual birth defects are rare, absolute risks should drive treatment decisions.Birth Defects Research (Part A) 106:940–949, 2016.© 2016 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - November 27, 2016 Category: Perinatology & Neonatology Authors: Elizabeth C. Ailes, Suzanne M. Gilboa, Simerpal K. Gill, Cheryl S. Broussard, Krista S. Crider, Robert J. Berry, Tonia C. Carter, Charlotte A. Hobbs, Julia D. Interrante, Jennita Reefhuis, Tags: Research Article Source Type: research

Using insurance claims data to identify and estimate critical periods in pregnancy: An application to antidepressants
ConclusionThis work will inform future efforts to estimate medication dispensations during critical periods of preconception, interconception, and pregnancy using health insurance claims data. Birth Defects Research (Part A) 106:927–934, 2016. © 2016 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - November 27, 2016 Category: Perinatology & Neonatology Authors: Elizabeth C. Ailes, Regina M. Simeone, April L. Dawson, Emily E. Petersen, Suzanne M. Gilboa Tags: Research Article Source Type: research

Characterizing facial features in individuals with craniofacial microsomia: A systematic approach for clinical research
ConclusionWe developed a standardized approach for integrating multiple data sources to phenotype individuals with CFM, and created subgroups based on clinically‐meaningful, shared characteristics. We hope that this system can be used to explore associations between phenotype and clinical outcomes of children with CFM and to identify the etiology of CFM. Birth Defects Research (Part A) 106:915–926, 2016.© 2016 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - November 27, 2016 Category: Perinatology & Neonatology Authors: Carrie L. Heike, Erin Wallace, Matthew L. Speltz, Babette Siebold, Martha M. Werler, Anne V. Hing, Craig B. Birgfeld, Brent R. Collett, Brian G. Leroux, Daniela V. Luquetti Tags: Research Article Source Type: research

ICD ‐10–based expanded code set for use in cleft lip/palate research and surveillance
ConclusionThe expanded set is “collapsible” into the official ICD‐10‐CM codes; this improves compatibility of the expanded codes that would be contained in research and epidemiologic databases with the standard codes from hospital electronic medical record systems and administrative billing data. Birth Defects Research (Part A) 106:905–914, 2016. © 2016 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - November 27, 2016 Category: Perinatology & Neonatology Authors: Alexander C. Allori, Janet D. Cragan, Cynthia H. Cassell, Jeffrey R. Marcus Tags: Research Article Source Type: research

Evaluation of the Western Australian Register of Developmental Anomalies: Thirty ‐five years of surveillance
ConclusionStrengths of WARDA‐BD include high data quality, timeliness, representativeness, stable funding, active community engagement, and high staff retention. Its data were used in numerous epidemiologic investigations resulting in >325 peer‐reviewed publications. Potential weaknesses include the limited number of variables collected and low visibility. Although WARDA‐BD uses labor intensive case ascertainment and quality assurance and control processes, the Register provides accurate and essential data for stakeholders. Birth Defects Research (Part A) 106:894–904, 2016. © 2016 Wiley Periodicals, Inc. (Sourc...
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - November 27, 2016 Category: Perinatology & Neonatology Authors: Wendy N. Nembhard, Carol Bower Tags: Research Article Source Type: research

Surveillance of ventricular septal defects in Delaware
ConclusionThe BDR team chose to include all babies with all types of VSDs. Using these criteria Delaware's prevalence of 78.7 was higher than that reported by other states (whose prevalence ranges from 1.6 to 70.0 per 10,000 live births) (National Birth Defects Prevention Network, ). Delaware's prevalence is similar to other states when small muscular VSDs are excluded. Birth Defects Research (Part A) 106:888–893, 2016. © 2016 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - November 27, 2016 Category: Perinatology & Neonatology Authors: Amy Acheson, Anika Vaidy, Kathleen Stomieroski, Dana R. Thompson, Kristin M. Maiden, Deborah B. Ehrenthal, Samir Yezdani, Abdul Majeed Bhat, Robert Locke, Louis E. Bartoshesky Tags: Research Article Source Type: research

Geographic distribution of live births with tetralogy of Fallot in North Carolina 2003 to 2012
ConclusionApproximately 50 infants/year were born with TOF in NC. One cluster was identified. Further study is necessary to explore potential explanations for the observed case cluster. As interest in regionalization of congenital heart surgery grows, GIS and spatial analysis can become increasingly useful tools for health care planning. Birth Defects Research (Part A) 106:881–887, 2016. © 2016 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - November 27, 2016 Category: Perinatology & Neonatology Authors: Jennifer S. Nelson, Rebecca C. Stebbins, Paula D. Strassle, Robert E. Meyer Tags: Research Article Source Type: research

Using state and provincial surveillance programs to reduce risk of recurrence of neural tube defects in the United States and Canada: A missed opportunity?
ConclusionThe number of birth defects surveillance programs with NTD recurrence prevention activities has decreased over the past decade due to a range of barriers, most notably a lack of resources. However, while some recurrence prevention activities require part‐time staff, other activities could be accomplished using minimal resources. Birth Defects Research (Part A) 106:875–880, 2016.© 2016 Wiley Periodicals, Inc. (Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - November 27, 2016 Category: Perinatology & Neonatology Authors: Timothy J. Flood, Chelsea M. Rienks, Alina L. Flores, Cara T. Mai, Barbara K. Frohnert, Rachel E. Rutkowski, Jane A. Evans, Russell S. Kirby Tags: Research Article Source Type: research

Editorial brain malformation surveillance in the Zika era
The current surveillance systems for congenital microcephaly are necessary to monitor the impact of Zika virus (ZIKV) on the developing human brain, as well as the ZIKV prevention efforts. However, these congenital microcephaly surveillance systems are insufficient. Abnormalities of neuronal differentiation, development and migration may occur among infants with normal head circumference who have intrauterine exposure to ZIKV. Therefore, surveillance for congenital microcephaly does not ascertain many of the infants seriously impacted by congenital ZIKV infection. Furthermore, many infants with normal head circumference an...
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - November 27, 2016 Category: Perinatology & Neonatology Authors: Edwin Trevathan Tags: Editorial Source Type: research

Editorial advances in population ‐based birth defects surveillance, epidemiology, and public health practice
(Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - November 27, 2016 Category: Perinatology & Neonatology Authors: Russell S. Kirby, Marilyn L. Browne Tags: Editorial Source Type: research

Issue Information
(Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - November 27, 2016 Category: Perinatology & Neonatology Tags: Issue Information Source Type: research

Cover Image
(Source: Birth Defects Research Part A: Clinical and Molecular Teratology)
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - November 27, 2016 Category: Perinatology & Neonatology Tags: Cover Image Source Type: research

Genomic approaches to the assessment of human spina bifida risk
Structural birth defects are a leading cause of mortality and morbidity in children world‐wide, affecting as much as 6% of all live births. Among these conditions, neural tube defects (NTDs), including spina bifida and anencephaly, arise from a combination of complex gene and environment interactions that are as yet poorly understood within human populations. Rapid advances in massively parallel DNA sequencing and bioinformatics allow for analyses of the entire genome beyond the 2% of the genomic sequence covering protein coding regions. Efforts to collect and analyze these large datasets hold promise for illuminating ge...
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - November 23, 2016 Category: Perinatology & Neonatology Authors: M. Elizabeth Ross, Christopher E. Mason, Richard H. Finnell Tags: Review Article Source Type: research