Analysis of crosstalk between retinoic acid and sonic hedgehog pathways following ethanol exposure in embryonic zebrafish

ConclusionThese studies demonstrate that while reduction of either RA or Shh signaling produces the same disruption of MHB or ocular development, that can be phenocopied using ethanol combined with either MO, RA overexpression can only rescue disrupted MHB, but not microphthalmia, in combined subthreshold Shh MO and ethanol. Our data suggest that MHB development may involve crosstalk between RA and Shh signaling, while ocular development depends on RA and Shh signaling that both are targets of ethanol in fetal alcohol spectrum disorders but do not depend on a mechanism involving crosstalk. Birth Defects Research (Part A), 2015. © 2015 Wiley Periodicals, Inc.
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - Category: Perinatology & Neonatology Authors: Tags: Original Research Article Source Type: research