Probiotics for childhood functional gastrointestinal disorders: do we know what we advise?
Conclusions: Increased familiarity and appropriate advising of probiotics in treatment of childhood FAPDs and FDD among pediatricians and GPs is required. Improved familiarity of probiotics is important to provide appropriate information about probiotic use to children and caregivers and may facilitate shared decision-making.Graphical abstract (Source: PharmaNutrition)
Source: PharmaNutrition - June 26, 2019 Category: Nutrition Source Type: research
First and second generation Probiotic therapeutics for Inflammatory Bowel Disease
Publication date: Available online 22 June 2019Source: PharmaNutritionAuthor(s): Srijita Sireswar, Ishita Ghosh, Gargi DeyAbstractThe interaction between the intestinal biota and humans have co-evolved, directing both to a state of complementary tolerance. However, dysbiosis in intestinal microbiota leads to inflammatory bowel disease which results from an aggressive immune response towards specific components of the commensal, enteric bacteria in a genetically susceptible host. One of the popular strategies for prophylaxis and treatment of inflammatory bowel disease has been the use of immune-regulatory probiotic formulat...
Source: PharmaNutrition - June 25, 2019 Category: Nutrition Source Type: research
The Nagoya Protocol on Access to Genetic Resources and Benefit Sharing: Best practices for users of Lactic Acid Bacteria
Publication date: Available online 15 June 2019Source: PharmaNutritionAuthor(s): Joost Flach, Carolina dos S. Ribeiro, Mark B. van der Waal, Raymond X. van der Waal, Eric Claassen, Linda H.M. van de BurgwalAbstractLactic Acid Bacteria (LAB) have an immense potential to prevent or treat disease and therefore see vast applications in pharmaceutical and food industries. Global collaboration and open innovation, where LAB are shared and their genomes are sequenced, are essential for the study and discovery of new underlying probiotic effects. However, recent efforts of the Nagoya Protocol (NP) to the Convention on Biological D...
Source: PharmaNutrition - June 16, 2019 Category: Nutrition Source Type: research
Involvement and Purchasing Motives of Dietary Supplements: A consumer study from Germany
Publication date: Available online 5 June 2019Source: PharmaNutritionAuthor(s): Carolin Kamrath, Sukhada Bidkar, Stefanie BröringAbstractConsumer demand for health-enhancing food is increasing. However, the definition of food is rather broad in the context of the European Union. The regulation (EC) No. 178/2002 considers both ordinary food products and dietary supplements as food, although their presentation format and functionalities may considerably differ. This may imply a difference in consumers’ involvement in purchasing decisions of ordinary food products and dietary supplements. To this end, we explore consumersâ...
Source: PharmaNutrition - June 6, 2019 Category: Nutrition Source Type: research
Editorial Board
Publication date: June 2019Source: PharmaNutrition, Volume 8Author(s): (Source: PharmaNutrition)
Source: PharmaNutrition - June 5, 2019 Category: Nutrition Source Type: research
A pilot study to evaluate Tolerability and Safety of a Modified Atkins Diet in ADPKD patients
ConclusionsOur study showed the modified Atkins diet is able to reduce glucose availability and it, is well tolerated by adult patients with ADPKD.Graphical abstract (Source: PharmaNutrition)
Source: PharmaNutrition - June 1, 2019 Category: Nutrition Source Type: research
Lipid-lowering Effect of Phyllanthus embilica and Alpinia galanga Extracts on HepG2 cell line
Publication date: Available online 22 May 2019Source: PharmaNutritionAuthor(s): Napatara Tirawanchai, Preeyanut Homongkol, Chaisak Chansriniyom, Anchaleekorn Somkasetrin, Jiraporn Jantaravinid, Kanchana Kengkoom, Sumate AmpawongAbstractDyslipidemia is a key risk factor for cardiovascular diseases. Although statins are powerful therapeutic option for achieving target low- and high-density lipoprotein levels, it is of interest to seek for alternative treatments for dyslipidemia. Phyllanthus emblica and Alpinia galangal were found to have hypolipidemic effects. However, the mechanisms underlying their bioactivity have not yet...
Source: PharmaNutrition - May 23, 2019 Category: Nutrition Source Type: research
Comparative Effects of Horseradish (Moringa oleifera) Leaves and Seeds on Blood Pressure and Crucial Enzymes Relevant to Hypertension in Rat
Publication date: Available online 10 May 2019Source: PharmaNutritionAuthor(s): Stephen Adeniyi Adefegha, Ganiyu Oboh, Alex Emmacume Iyoha, Ademola Adetokunbo OyagbemiAbstractHorseradish (Moringa oleifera) is consumed as a vegetable and used for medicinal purposes. The effects of horseradish (Moringa oleifera) leaves and seeds on blood pressure measurement, enzymatic and non-enzymatic antioxidant status and critical enzymes [angiotensin-1 converting enzyme (ACE), acetylcholinesterase (AChE), arginase, phosphodiesterase-5 (PDE-5)] relevant to hypertension in vivo were determined. Hypertensive rats (HYP) were placed on dieta...
Source: PharmaNutrition - May 11, 2019 Category: Nutrition Source Type: research
In vivo protective effect of Rosmarinus officinalis oil against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats
This study aimed to explore the hepatoprotective effects of cold-pressed R. officinalis oil (CPRO) against CCl4-induced liver toxicity in the experimental rats. Fatty acids and bioactive lipids of CPRO were analyzed. CPRO was orally administered to rats in two doses (100 and 200 mg/kg) along with CCl4 (1 mL/kg in olive oil) for 8 weeks. Indices of liver and kidney functions, lipid profile and oxidation were evaluated in rats’ serum and tissues. In CPRO the percentages of polyunsaturated, monounsaturated, and saturated fatty acids were 42.3%, 41.7%, and 15.8%, respectively. CPRO contained high amounts of total phenoli...
Source: PharmaNutrition - May 8, 2019 Category: Nutrition Source Type: research
Nanosized Selenium and Loranthus micranthus leaves ameliorate Streptozotocin-induced hepato-renal dysfunction in rats via enhancement of antioxidant system, regulation of Caspase 3 and Nrf2 protein expression
Publication date: Available online 1 May 2019Source: PharmaNutritionAuthor(s): Azubuike P. Ebokaiwe, Omamuyovwi M. Ijomone, Sharoon Griffin, Richard C. Ehiri, Kebe E. Obeten, Joseph O. Nw.wo, Chukwunonso E.C.C. Ejike, Cornelia M. KeckAbstractThe investigation of potential health benefits of nano-sized nutriceuticals is recently a major scientific interest. The present study investigated the effect of Selenium and Loranthus micranthus leaves nanoparticles (SeNPs and LMLNPs), on streptozotocin (STZ)-diabetes induced hepato-renal dysfunction in rats. Adult rats were rendered diabetic by a single i.p exposure to 40 mg/kg STZ...
Source: PharmaNutrition - May 2, 2019 Category: Nutrition Source Type: research
Arginine, Histidine and Tryptophan: a New Hope for Cancer Immunotherapy
Publication date: Available online 25 April 2019Source: PharmaNutritionAuthor(s): Ahmed A. Tantawy, Deyala M. NaguibAbstractCancer immunotherapy has gradually changed the prognosis of cancer patients. Recently, much evidence including novel antibodies that can close T cell barriers has indicated that immunotherapy is successful in certain patients. A shortage of dietary amino acids decreases animals and humans immunity to diseases. Amino acids regulate (1) T lymphocytes, B lymphocytes, natural killer cells and macrophages activation; (2) the redox state of the cell and gene; and (3) antibodies, cytokines and other cytotoxi...
Source: PharmaNutrition - April 26, 2019 Category: Nutrition Source Type: research
Maternal Supplementation with Lactobacillus paracasei DTA 83 Alters Emotional Behavior in Swiss Mice Offspring
The objective of our study was to evaluate whether maternal supplementation with lactic acid bacteria is able to alter neurobehavioral parameters of Swiss mice offspring. For this purpose, female mice were treated during pregnancy and lactation with milk or milk inoculated with L. paracasei DTA 83 at a concentration of 107 cells/ml (p.o, daily). After the end of the treatment, 6 offspring per group were submitted to euthanasia and the hippocampus was dissected for RNA analysis. After completing 70 days of life, 12 male offspring per group were submitted to a battery of behavioral tests. According to our results, treated of...
Source: PharmaNutrition - April 14, 2019 Category: Nutrition Source Type: research
Biotin improves relaxation of rat aortic rings in combination with antihypertensive drugs
In this study, we investigated the effect of biotin (10 nM) on arterial contraction in rat aortic rings with or without an endothelium induced by phenylephrine (1 × 10-9 to 1 × 10-5 M) or calcium (1 × 10-6 to 1 × 10-2.5 M) in the presence of antihypertensive drugs (BMY 7378, 100 nM; captopril, 1 µM; or nitrendipine, 100 nM). Biotin suppressed phenylephrine-induced vasoconstriction, which is partly modulated via endothelium-independent mechanisms. Biotin incubation with BMY 7378, captopril or nitrendipine improved the vasorelaxant effects of these drugs on aortic rings contracted by phenylephrine ...
Source: PharmaNutrition - March 28, 2019 Category: Nutrition Source Type: research
Antihypertensive effects of the Vitis vinifera grape skin (ACH09) extract consumption elicited by functional improvement of P1 (A1) and P2 (P2X1) purinergic receptors in diabetic and hypertensive rats
In conclusion, these findings suggest that dietary supplementation with polyphenolic-rich foods (lentil, citrus fruit and/or red wine) may inspire new pharmacologic and dietetic therapeutic approaches for treatment of hypertension and diabetes.Graphical abstract (Source: PharmaNutrition)
Source: PharmaNutrition - March 27, 2019 Category: Nutrition Source Type: research
Modulation of GSK - 3β/β - catenin cascade by commensal bifidobateria plays an important role for the inhibition of metaflammation-related biomarkers in response to LPS or non-physiological concentrations of fructose: An in vitro study
ConclusionWe describe a regulatory mechanism in which commensal bifidobacteria prevent LPS- and/or fructose-mediated transcriptional activation of metabolic disorder-causing factors (IL-1β, IL-6, TNF-α) and disruption of normal cellular energy metabolism by attenuating NF-kB activity and interfering with the Wnt/β-catenin pathway. The latter positively regulates NF-κB activity, thereby simultaneously reducing cellular triglyceride concentrations and enhancing cellular glucose consumption. This may be a molecular basis by which commensal bifidobacteria enhance intrinsic cellular tolerance against excess consumption of e...
Source: PharmaNutrition - March 22, 2019 Category: Nutrition Source Type: research
