Curcumin inhibition of the effects of Tip α induced cytokine expression in gastric cancer patients
Publication date: September 2018Source: PharmaNutrition, Volume 6, Issue 3Author(s): Pattama Wongsirisin, Supachai Yodkeeree, Sirikan Limpakan (Yamada), Pornngarm Limtrakul (Dejkriengkraikul)AbstractHelicobacter pylori (H. pylori) is a major risk factor for gastric cancer. TNF-α inducing protein (Tip α) is an inflammatory factor of H. pylori. It can induce inflammatory cytokine secretion via the NF-kB signaling pathway. The aim of this study is to investigate whether curcumin, a natural NF-kB inhibitor, can reverse the effects of Tip α-induced cytokine expression in gastric cancer subjects both in vitro and ex vivo. The...
Source: PharmaNutrition - July 5, 2018 Category: Nutrition Source Type: research
Glucose prevents cisplatin-induced fatigue-like behavior in mice
Publication date: September 2018Source: PharmaNutrition, Volume 6, Issue 3Author(s): Kazumi Yoshizawa, Aoi Yamane, Haruka Nasu, Hidetaka SuzukiAbstractFatigue is recognized as one of the most common and distressing side effects of cancer and anticancer therapy. In the present study, we used mice without cancer to examine the specific influence of chemotherapy on fatigue. Mice were administered a single dose of cisplatin (CDDP; 10 mg/kg, i.p.) or saline as a control, and then were treated with glucose (500 or 5000 mg/kg p.o.), olive oil (10 ml/kg p.o.), or saline daily for 4 days. At 24 h after the final dose of glu...
Source: PharmaNutrition - July 5, 2018 Category: Nutrition Source Type: research
A double-blind, randomized, placebo-controlled, three-way crossover clinical investigation to evaluate the effect of IQP-VV-102 on postprandial blood glucose reduction
In conclusion, IQP-VV-102 exhibited a dose-dependent effect in reducing postprandial blood glucose levels with no disproportionate increase in insulin levels and was well tolerated.Graphical abstract (Source: PharmaNutrition)
Source: PharmaNutrition - July 5, 2018 Category: Nutrition Source Type: research
Zinc supplementation reduces inflammation in ulcerative colitis patients by downregulating gene expression of Zn metalloproteins
In conclusion, Zn supplementation downregulates the expression of metalloproteins that transport Zn, causing a higher accumulation of Zn, and supporting a correlation between Zn homeostasis and immune response in ulcerative colitis.Graphical abstract (Source: PharmaNutrition)
Source: PharmaNutrition - July 5, 2018 Category: Nutrition Source Type: research
Influence of fisetin combined with hesperidin on chronic mild hyperhomocysteinemia induced cognitive dysfunction and oxidative stress in wistar rats
This study was aimed to evaluate the neuroprotective role of fisetin and hesperidin on homocysteine induced chronicmild hyperhomocysteinemia in wistar rats. DL-homocysteine (0.03 μmoL/g/ b.w,s.c.twice a day) administration from 30th–62nd postpartum day in rats induced chronic mild hyperhomocysteinemia. Rats were then evaluated for cognitive dysfunction, oxidative/nitrative stress and several biochemical as well as morphological parameters of brain cortex and hippocampus. Our results indicate that chronic mild hyperhomocysteinemia induced cognitive impairment, increased serum homocysteine, brain acetylcholinesterase, l...
Source: PharmaNutrition - July 5, 2018 Category: Nutrition Source Type: research
l-Arginine treatment improves angiogenic response and reduces matrix metalloproteinase activity in chronic heart failure patients with coronary artery disease
This study was undertaken to evaluate effects of l-arginine on the levels of key angiogenic regulators and matrix metalloproteinase (MMP) activity in sera of chronic heart failure (CHF) patients with CAD. Thirty-three patients were divided into two groups: 1) received only the standard treatment (control group, n = 13); 2) received l-arginine intravenous infusions in the dose of 4.2 g /100 mL for 7 days, followed by oral supplementation in the daily dose of 6 g for 3 months (n = 20). Significant up-regulation of vascular endothelial growth factor (VEGF) was found immunochemically in sera of l-arginine-treated...
Source: PharmaNutrition - July 5, 2018 Category: Nutrition Source Type: research
Jaboticaba peel extract supress autophagy in white adipose tissue and prevents metabolic disorders in mice fed with a high-fat diet
Publication date: Available online 30 June 2018 Source:PharmaNutrition Author(s): Andressa Mara Baseggio, Carla Evelyn Coimbra Nuñez, Nathalia Romanelli Vicente Dragano, Celina Almeida Lamas, Patrícia Aparecida de Campos Braga, Sabrina Alves Lenquiste, Felix Guillermo Reyes Reyes, Valéria Helena Alves Cagnon, Mário Roberto Maróstica Júnior The increase in autophagy markers in the white adipose tissue is associated with adipocyte hypertrophy and obesity physiopathology. The jaboticaba peel is rich in bioactive compounds as polyphenols, which have been demonstrating anti-oxidant and inflammatory effects, and...
Source: PharmaNutrition - July 1, 2018 Category: Nutrition Source Type: research
Influence of fisetin combined with hesperidin on chronic mild hyperhomocysteinemia induced cognitive dysfunction and oxidative stress in wistar rats
This study was aimed to evaluate the neuroprotective role of fisetin and hesperidin on homocysteine induced chronicmild hyperhomocysteinemia in wistar rats. DL-homocysteine (0.03 μmoL/g/ b.w,s.c.twice a day) administration from 30th–62nd postpartum day in rats induced chronic mild hyperhomocysteinemia. Rats were then evaluated for cognitive dysfunction, oxidative/nitrative stress and several biochemical as well as morphological parameters of brain cortex and hippocampus. Our results indicate that chronic mild hyperhomocysteinemia induced cognitive impairment, increased serum homocysteine, brain acetylcholinesterase, l...
Source: PharmaNutrition - June 30, 2018 Category: Nutrition Source Type: research
Zinc supplementation reduces inflammation in ulcerative colitis patients by downregulating gene expression of Zn metalloproteins
In conclusion, Zn supplementation downregulates the expression of metalloproteins that transport Zn, causing a higher accumulation of Zn, and supporting a correlation between Zn homeostasis and immune response in ulcerative colitis. Graphical abstract (Source: PharmaNutrition)
Source: PharmaNutrition - June 30, 2018 Category: Nutrition Source Type: research
L-arginine treatment improves angiogenic response and reduces matrix metalloproteinase activity in chronic heart failure patients with coronary artery disease
This study was undertaken to evaluate effects of L-arginine on the levels of key angiogenic regulators and matrix metalloproteinase (MMP) activity in sera of chronic heart failure (CHF) patients with CAD. Thirty-three patients were divided into two groups: 1) received only the standard treatment (control group, n = 13); 2) received L-arginine intravenous infusions in the dose of 4.2 g /100 mL for 7 days, followed by oral supplementation in the daily dose of 6 g for 3 months (n = 20). Significant up-regulation of vascular endothelial growth factor (VEGF) was found immunochemically in sera of L-arginine-treated...
Source: PharmaNutrition - June 27, 2018 Category: Nutrition Source Type: research
Effects of zinc supplementation on inflammatory response and gene expression of Zn metalloproteins in patients with ulcerative colitis
In conclusion, Zn supplementation downregulates the expression of metalloproteins that transport Zn, causing a higher accumulation of Zn, and supporting a correlation between Zn homeostasis and immune response in ulcerative colitis. Graphical abstract (Source: PharmaNutrition)
Source: PharmaNutrition - June 19, 2018 Category: Nutrition Source Type: research
Natural dietary antioxidants, fisetin and hesperidin ameliorate chronic mild hyperhomocysteinemia induced cognitive dysfunction and oxidative stress in Wistar rats
This study was aimed to evaluate the neuroprotective role of fisetin and hesperidin on homocysteine induced cognitive dysfunction, oxidative/nitrative stress,inflammatory and morphological parameters of brain cortex and hippocampus of rats subjected to chronic mild hyperhomocysteinemia. Male wistar rats received DL-homocysteine (0.03 µmoL/g /b.w.) by subcutaneous route twice daily and control and vehicle control ( 0.5 mL/kg and 10 mL/kg, b.w.) once daily from 30th - 62nd postpartum day. Rats received fisetin (25 mg/kg/b.w.), hesperidin (100 mg/kg/b.w.), combination (25 + 100 mg/kg/b.w.) and donepezil (0.1 ...
Source: PharmaNutrition - June 15, 2018 Category: Nutrition Source Type: research
A double-blind, randomized, placebo-controlled, three-way crossover clinical investigation to evaluate the effect of IQP-VV-102 on postprandial blood glucose reduction
In conclusion, IQP-VV-102 exhibited a dose-dependent effect in reducing postprandial blood glucose levels with no disproportionate increase in insulin levels and was well tolerated. Graphical abstract (Source: PharmaNutrition)
Source: PharmaNutrition - June 10, 2018 Category: Nutrition Source Type: research
Glucose prevents cisplatin-induced fatigue-like behavior in mice
Publication date: Available online 5 June 2018 Source:PharmaNutrition Author(s): Kazumi Yoshizawa, Aoi Yamane, Haruka Nasu, Hidetaka Suzuki Fatigue is recognized as one of the most common and distressing side effects of cancer and anticancer therapy. In the present study, we used mice without cancer to examine the specific influence of chemotherapy on fatigue. Mice were administered a single dose of cisplatin (CDDP; 10 mg/kg, i.p.) or saline as a control, and then were treated with glucose (500 or 5000 mg/kg p.o.), olive oil (10 ml/kg p.o.), or saline daily for 4 days. At 24 h after the final dose of glucose,...
Source: PharmaNutrition - June 6, 2018 Category: Nutrition Source Type: research
Curcumin inhibition of the effects of Tip α induced cytokine expression in gastric cancer patients
Publication date: Available online 31 May 2018 Source:PharmaNutrition Author(s): Pattama Wongsirisin, Supachai Yodkeeree, Sirikan Limpakan (Yamada), Pornngarm Limtrakul Helicobacter pylori (H. pylori) is a major risk factor for gastric cancer. TNF-α inducing protein (Tip α) is an inflammatory factor of H. pylori. It can induce inflammatory cytokine secretion via the NF-kB signaling pathway. The aim of this study is to investigate whether curcumin, a natural NF-kB inhibitor, can reverse the effects of Tip α-induced cytokine expression in gastric cancer subjects both in vitro and ex vivo. The inhibitory effects of c...
Source: PharmaNutrition - June 1, 2018 Category: Nutrition Source Type: research
