Let Astaxanthin be thy Medicine
Publication date: Available online 9 September 2015 Source:PharmaNutrition Author(s): Eiji Yamashita Astaxanthin is known as a “marine carotenoid” and occurs in a wide variety of living organisms such as salmon, shrimp, crab, and red snapper. Astaxanthin antioxidant activity has been reported to be more than 100 times greater than that of vitamin E against lipid peroxidation and approximately 550 times more potent than that of vitamin E for singlet oxygen quenching. Astaxanthin exhibits no pro-oxidant activity and its main site of action is on/in the cell membrane. To date, various important benefits suggested fo...
Source: PharmaNutrition - September 11, 2015 Category: Nutrition Source Type: research
Clinical applications of curcumin
This article summarizes a number of basic studies and clinical trials involving curcumin and discusses the potential for clinical use of curcumin. Graphical abstract (Source: PharmaNutrition)
Source: PharmaNutrition - August 14, 2015 Category: Nutrition Source Type: research
Clinical benefits of green tea consumption for cognitive dysfunction
Publication date: Available online 21 July 2015 Source:PharmaNutrition Author(s): Kazuki Ide, Hiroshi Yamada The prevalence of cognitive dysfunction, and particularly dementia, is increasing rapidly among older adults worldwide. There is currently no cure for dementia. In this situation, pharmaceutical and non-pharmaceutical combination therapies capable of preventing or slowing the progression of cognitive dysfunction are important. Nutritional intervention provides an important non-pharmaceutical approach in clinical practice. Green tea has the potential to contribute to this nutritional approach. Experimental st...
Source: PharmaNutrition - July 30, 2015 Category: Nutrition Source Type: research
The clinical benefits of green tea consumption for cognitive dysfunction
Publication date: Available online 21 July 2015 Source:PharmaNutrition Author(s): Kazuki Ide, Hiroshi Yamada The prevalence of cognitive dysfunction, and particularly dementia, is increasing rapidly among older adults worldwide. There is currently no cure for dementia. In this situation, pharmaceutical and non-pharmaceutical combination therapies capable of preventing or slowing the progression of cognitive dysfunction are important. Nutritional intervention provides an important non-pharmaceutical approach in clinical practice. Green tea has the potential to contribute to this nutritional approach. Experimental st...
Source: PharmaNutrition - July 21, 2015 Category: Nutrition Source Type: research
Resolvin D1 decreases caspase-3 activation in the limbic system after myocardial infarction
In conclusion, RvD1 could reduce infarct size and caspase-3 activity in the amygdala and hippocampus. (Source: PharmaNutrition)
Source: PharmaNutrition - July 17, 2015 Category: Nutrition Source Type: research
The Omega-3 Fatty Acid Deficiency Syndrome: Opportunities for Disease Prevention
Publication date: April 2015 Source:PharmaNutrition, Volume 3, Issue 2 Author(s): Richard Bazinet (Source: PharmaNutrition)
Source: PharmaNutrition - June 17, 2015 Category: Nutrition Source Type: research
The therapeutic potential of Physalis longifolia against various carcinomas
Publication date: Available online 22 May 2015 Source:PharmaNutrition Author(s): Robert J. Gallagher , Chitra Subramanian , Patrick T. Grogan , Kelly Kindscher , Cong-Mei Cao , Huaping Zhang , Mark S. Cohen , Barbara N. Timmermann Our research highlights the nutraceutical potential of the fruits of Physalis longifolia Nutt. (Solanaceae) in antitumor therapy. Recently we reported the isolation of withaferin A, along with 22 other withanolides from the aerial parts of P. longifolia. Herein, we present our biological, ethnobotanical, and phytochemical investigations on the edible fruit (known as “wild tomatillo...
Source: PharmaNutrition - May 23, 2015 Category: Nutrition Source Type: research
Combination of low dose major n3 PUFAs in fresh water mussel lipid is an alternative of EPA–DHA supplementation in inflammatory conditions of arthritis and LPS stimulated macrophages
This study, for the first time, showed anti-inflammatory potential of lipid from a fresh water species. It has also raised the possibility of the presence of balanced fatty acid combination in a dietary dose, rather than the established EPA–DHA supplement, to be more effective against inflammatory conditions of arthritis and LPS stimulated macrophages. Graphical abstract (Source: PharmaNutrition)
Source: PharmaNutrition - May 22, 2015 Category: Nutrition Source Type: research
Self-nanoemulsifying particles of coenzyme Q10 with improved nutraceutical potential
Publication date: Available online 15 May 2015 Source:PharmaNutrition Author(s): Satomi Onoue , Atushi Uchida , Tatsuya Nakamura , Kazuki Kuriyama , Junya Hatanaka , Toshiyuki Tanaka , Hiroyuki Miyoshi , Yoshiki Seto , Shizuo Yamada The major purpose of the present study was to clarify the physicochemical and nutraceutical properties of self-nanoemulsifying particles of coenzyme Q10 (CoQ10/SNEP). Nanoemulsion preconcentrate, containing CoQ10, medium-chain triglyceride, sucrose ester of fatty acid, and hydroxypropyl cellulose, was spray-dried to produce the CoQ10/SNEP. The CoQ10/SNEP was stored at 40 °C with o...
Source: PharmaNutrition - May 15, 2015 Category: Nutrition Source Type: research
Molecular weight and sulfate content modulate the inhibition of α-amylase by fucoidan relevant for type 2 diabetes management
Publication date: Available online 27 February 2015 Source:PharmaNutrition Author(s): Kyung-Tae Kim , Laurie-Eve Rioux , Sylvie L. Turgeon Fucoidan showed the potential of functioning as an α-amylase inhibitor, which is an important discovery for natural health products uses for diabetes prevention. The inhibitory activity was shown to differ, depending on the seaweed species. To identify the key structural factors of fucoidan that are necessary for its α-amylase inhibitory activity, glycosidic linkage position, sulfate content, and molecular weight, have been comparatively performed using the fucoidans obtained f...
Source: PharmaNutrition - May 8, 2015 Category: Nutrition Source Type: research
A multispecies Lactobacillus- and Bifidobacterium-containing probiotic mixture attenuates body weight gain and insulin resistance after a short-term challenge with a high-fat diet in C57/BL6J mice
Publication date: Available online 1 April 2015 Source:PharmaNutrition Author(s): Sophie Holowacz , Charlotte Guigné , Gérald Chêne , Sandrine Mouysset , Angèle Guilbot , Christian Seyrig , Marc Dubourdeau A multispecies Lactobacillus- and Bifidobacterium-containing probiotic mixture significantly reduced the adverse metabolic and inflammatory effects of a 14-week high-fat diet in wild-type C57/BL6J mice gavaged 5 days a week with the probiotic mixture or vehicle. Recent evidence indicates that the gut microbiome may play a decisive role in the onset of obesity and associated chronic metabolic diseases, such...
Source: PharmaNutrition - May 8, 2015 Category: Nutrition Source Type: research
Omega-3 Fatty Acid Status: Gene–Diet Interactions
Publication date: April 2015 Source:PharmaNutrition, Volume 3, Issue 2 Author(s): Richard Bazinet (Source: PharmaNutrition)
Source: PharmaNutrition - May 8, 2015 Category: Nutrition Source Type: research
Xenobiotics and human health: A new view of their pharma-nutritional role
Publication date: April 2015 Source:PharmaNutrition, Volume 3, Issue 2 Author(s): Francesco Visioli The current interest in xenobiotics is being revamped by the quite recent re-evaluation of dietary antioxidants, namely polyphenols as mildly noxious compounds rather than true in vivo antioxidants. Consequently, our view on the role of xenobiotics in human health is shifting. While many dietary compounds are toxic when ingested in excessive amounts, a wide array of plant-derived xenobiotics, namely polyphenols, actually activate Phase II enzymes and augment our defenses toward subsequent noxious stimuli. Therefore, the...
Source: PharmaNutrition - May 8, 2015 Category: Nutrition Source Type: research
Role of natural antioxidants and potential use of bergamot in treating rheumatoid arthritis
Publication date: April 2015 Source:PharmaNutrition, Volume 3, Issue 2 Author(s): A. Marino , I. Paterniti , M. Cordaro , R. Morabito , M. Campolo , M. Navarra , E. Esposito , S. Cuzzocrea The aim of the present review is to report about the effect of natural compounds, with proved antioxidant activity and mainly introduced with diet, on rheumatoid arthritis (RA). RA is a chronic, systemic inflammatory disorder leading to cartilage damage, bone erosions, joint destruction and impaired movement. The pathophysiology of RA includes reactive oxygen species (ROS) production, which is concomitant with inflammation an...
Source: PharmaNutrition - May 8, 2015 Category: Nutrition Source Type: research
Modulatory effects of a cranberry extract co-supplementation with Bacillus subtilis CU1 probiotic on phenolic compounds bioavailability and gut microbiota composition in high-fat diet-fed mice
This study thus highlights the impact of an altered gut microbiota on phenolic compounds degradation and bioavailability in mice. Graphical abstract (Source: PharmaNutrition)
Source: PharmaNutrition - May 8, 2015 Category: Nutrition Source Type: research
