Accelerating microbiota product development: The Societal Impact Value Cycle as a conceptual model to shape and improve public-private valorization processes
Publication date: Available online 17 July 2018Source: PharmaNutritionAuthor(s): L.H.M. Van de Burgwal, M.B. Van der Waal, E. ClaassenAbstractDespite their potential for preventing and reducing diseases, the availability of marketed probiotics with a relevant health or risk reduction claim is lagging behind. Food and pharmaceutical companies, as well as universities, are challenged to collaborate across the innovation value chain to deliver on the promises of microbiota research and development. A shared understanding of the knowledge valorization process is essential for the success of such public-private partnerships. Co...
Source: PharmaNutrition - July 18, 2018 Category: Nutrition Source Type: research
Jaboticaba peel extract supress autophagy in white adipose tissue and prevents metabolic disorders in mice fed with a high-fat diet
Publication date: Available online 30 June 2018Source: PharmaNutritionAuthor(s): Andressa Mara Baseggio, Carla Evelyn Coimbra Nuñez, Nathalia Romanelli Vicente Dragano, Celina Almeida Lamas, Patrícia Aparecida de Campos Braga, Sabrina Alves Lenquiste, Felix Guillermo Reyes Reyes, Valéria Helena Alves Cagnon, Mário Roberto Maróstica JúniorAbstractThe increase in autophagy markers in the white adipose tissue is associated with adipocyte hypertrophy and obesity physiopathology. The jaboticaba peel is rich in bioactive compounds as polyphenols, which have been demonstrating anti-oxidant and inflammatory effects, and poss...
Source: PharmaNutrition - July 10, 2018 Category: Nutrition Source Type: research
Diets supplemented with Annona muricata improve the symptoms of fibromyalgia
In this study, the effect of the consumption of Annona muricata L. (Annonaceae) leaves (AM) was investigated on a model for intermittent cold stress (ICS)-induced fibromyalgia in mice. An aqueous extract of AM was investigated in experiments involving 60 five-week-old female mice C57BL/6J.The animals were allocated into six groups (n = 10). Groups (I) Healthy control, (II) ICS control, and (III) ICS + acetaminophen (0.5%), were all fed a standard diet, while groups (IV) and (V) received standard diets supplemented with 15% (AM15) and 30% (AM30) aqueous extract of AM leaves, respectively. Group (VI) received a stand...
Source: PharmaNutrition - July 10, 2018 Category: Nutrition Source Type: research
A nutraceutical formulation based on Annurca apple polyphenolic extract is effective on intestinal cholesterol absorption: A randomised, placebo-controlled, crossover study
The objective of the present work was to evaluate the in vitro and clinical effects of a novel nutraceutical product (AMD), formulated with Annurca apple polyphenolic extracts, on the intestinal cholesterol micellar solubility. AMD was able to decrease in vitro cholesterol micellar solubility by about 85.7%, while Nuclear Magnetic Resonance experiments allowed to hypothesize dimeric procyanidins as potential responsible compounds for this effect. Then, a randomised, double blind, single centre, placebo-controlled, crossover study, was designed to evaluate the effect of AMD on the fecal cholesterol excretion. Clinical data ...
Source: PharmaNutrition - July 10, 2018 Category: Nutrition Source Type: research
The passive avoidance memory improving effect of curcumin in young adult mice: Considering hippocampal MMP-2, MMP-9 and Akt/GSK3β
This study aimed to assess the effect of curcumin on passive avoidance memory in adult young mice. Additionally, the hippocampal contents of MMP-2, MMP-9 and Akt/GSK3β were determined. Male mice weighing 20–25 g were trained in passive avoidance apparatus. Curcumin 50 or 100 mg/kg/po (according to our initial tests) or its vehicle was administered for 10 days. On day 10 the training was done and the retention trial was performed 24 h later. At the complement of behavioral studies, the hippocampal tissue was isolated and western blot analysis was performed for MMP-2, MMP-9 and Akt/GSK3β. The results indicated that...
Source: PharmaNutrition - July 10, 2018 Category: Nutrition Source Type: research
Curcumin inhibition of the effects of Tip α induced cytokine expression in gastric cancer patients
Publication date: September 2018Source: PharmaNutrition, Volume 6, Issue 3Author(s): Pattama Wongsirisin, Supachai Yodkeeree, Sirikan Limpakan (Yamada), Pornngarm Limtrakul (Dejkriengkraikul)AbstractHelicobacter pylori (H. pylori) is a major risk factor for gastric cancer. TNF-α inducing protein (Tip α) is an inflammatory factor of H. pylori. It can induce inflammatory cytokine secretion via the NF-kB signaling pathway. The aim of this study is to investigate whether curcumin, a natural NF-kB inhibitor, can reverse the effects of Tip α-induced cytokine expression in gastric cancer subjects both in vitro and ex vivo. The...
Source: PharmaNutrition - July 10, 2018 Category: Nutrition Source Type: research
Glucose prevents cisplatin-induced fatigue-like behavior in mice
Publication date: September 2018Source: PharmaNutrition, Volume 6, Issue 3Author(s): Kazumi Yoshizawa, Aoi Yamane, Haruka Nasu, Hidetaka SuzukiAbstractFatigue is recognized as one of the most common and distressing side effects of cancer and anticancer therapy. In the present study, we used mice without cancer to examine the specific influence of chemotherapy on fatigue. Mice were administered a single dose of cisplatin (CDDP; 10 mg/kg, i.p.) or saline as a control, and then were treated with glucose (500 or 5000 mg/kg p.o.), olive oil (10 ml/kg p.o.), or saline daily for 4 days. At 24 h after the final dose of glu...
Source: PharmaNutrition - July 10, 2018 Category: Nutrition Source Type: research
A double-blind, randomized, placebo-controlled, three-way crossover clinical investigation to evaluate the effect of IQP-VV-102 on postprandial blood glucose reduction
In conclusion, IQP-VV-102 exhibited a dose-dependent effect in reducing postprandial blood glucose levels with no disproportionate increase in insulin levels and was well tolerated.Graphical abstract (Source: PharmaNutrition)
Source: PharmaNutrition - July 10, 2018 Category: Nutrition Source Type: research
Zinc supplementation reduces inflammation in ulcerative colitis patients by downregulating gene expression of Zn metalloproteins
In conclusion, Zn supplementation downregulates the expression of metalloproteins that transport Zn, causing a higher accumulation of Zn, and supporting a correlation between Zn homeostasis and immune response in ulcerative colitis.Graphical abstract (Source: PharmaNutrition)
Source: PharmaNutrition - July 10, 2018 Category: Nutrition Source Type: research
Influence of fisetin combined with hesperidin on chronic mild hyperhomocysteinemia induced cognitive dysfunction and oxidative stress in wistar rats
This study was aimed to evaluate the neuroprotective role of fisetin and hesperidin on homocysteine induced chronicmild hyperhomocysteinemia in wistar rats. DL-homocysteine (0.03 μmoL/g/ b.w,s.c.twice a day) administration from 30th–62nd postpartum day in rats induced chronic mild hyperhomocysteinemia. Rats were then evaluated for cognitive dysfunction, oxidative/nitrative stress and several biochemical as well as morphological parameters of brain cortex and hippocampus. Our results indicate that chronic mild hyperhomocysteinemia induced cognitive impairment, increased serum homocysteine, brain acetylcholinesterase, l...
Source: PharmaNutrition - July 10, 2018 Category: Nutrition Source Type: research
l-Arginine treatment improves angiogenic response and reduces matrix metalloproteinase activity in chronic heart failure patients with coronary artery disease
This study was undertaken to evaluate effects of l-arginine on the levels of key angiogenic regulators and matrix metalloproteinase (MMP) activity in sera of chronic heart failure (CHF) patients with CAD. Thirty-three patients were divided into two groups: 1) received only the standard treatment (control group, n = 13); 2) received l-arginine intravenous infusions in the dose of 4.2 g /100 mL for 7 days, followed by oral supplementation in the daily dose of 6 g for 3 months (n = 20). Significant up-regulation of vascular endothelial growth factor (VEGF) was found immunochemically in sera of l-arginine-treated...
Source: PharmaNutrition - July 10, 2018 Category: Nutrition Source Type: research
Jaboticaba peel extract supress autophagy in white adipose tissue and prevents metabolic disorders in mice fed with a high-fat diet
Publication date: Available online 30 June 2018Source: PharmaNutritionAuthor(s): Andressa Mara Baseggio, Carla Evelyn Coimbra Nuñez, Nathalia Romanelli Vicente Dragano, Celina Almeida Lamas, Patrícia Aparecida de Campos Braga, Sabrina Alves Lenquiste, Felix Guillermo Reyes Reyes, Valéria Helena Alves Cagnon, Mário Roberto Maróstica JúniorAbstractThe increase in autophagy markers in the white adipose tissue is associated with adipocyte hypertrophy and obesity physiopathology. The jaboticaba peel is rich in bioactive compounds as polyphenols, which have been demonstrating anti-oxidant and inflammatory effects, and poss...
Source: PharmaNutrition - July 5, 2018 Category: Nutrition Source Type: research
Diets supplemented with Annona muricata improve the symptoms of fibromyalgia
In this study, the effect of the consumption of Annona muricata L. (Annonaceae) leaves (AM) was investigated on a model for intermittent cold stress (ICS)-induced fibromyalgia in mice. An aqueous extract of AM was investigated in experiments involving 60 five-week-old female mice C57BL/6J.The animals were allocated into six groups (n = 10). Groups (I) Healthy control, (II) ICS control, and (III) ICS + acetaminophen (0.5%), were all fed a standard diet, while groups (IV) and (V) received standard diets supplemented with 15% (AM15) and 30% (AM30) aqueous extract of AM leaves, respectively. Group (VI) received a stand...
Source: PharmaNutrition - July 5, 2018 Category: Nutrition Source Type: research
A nutraceutical formulation based on Annurca apple polyphenolic extract is effective on intestinal cholesterol absorption: A randomised, placebo-controlled, crossover study
The objective of the present work was to evaluate the in vitro and clinical effects of a novel nutraceutical product (AMD), formulated with Annurca apple polyphenolic extracts, on the intestinal cholesterol micellar solubility. AMD was able to decrease in vitro cholesterol micellar solubility by about 85.7%, while Nuclear Magnetic Resonance experiments allowed to hypothesize dimeric procyanidins as potential responsible compounds for this effect. Then, a randomised, double blind, single centre, placebo-controlled, crossover study, was designed to evaluate the effect of AMD on the fecal cholesterol excretion. Clinical data ...
Source: PharmaNutrition - July 5, 2018 Category: Nutrition Source Type: research
The passive avoidance memory improving effect of curcumin in young adult mice: Considering hippocampal MMP-2, MMP-9 and Akt/GSK3β
This study aimed to assess the effect of curcumin on passive avoidance memory in adult young mice. Additionally, the hippocampal contents of MMP-2, MMP-9 and Akt/GSK3β were determined. Male mice weighing 20–25 g were trained in passive avoidance apparatus. Curcumin 50 or 100 mg/kg/po (according to our initial tests) or its vehicle was administered for 10 days. On day 10 the training was done and the retention trial was performed 24 h later. At the complement of behavioral studies, the hippocampal tissue was isolated and western blot analysis was performed for MMP-2, MMP-9 and Akt/GSK3β. The results indicated that...
Source: PharmaNutrition - July 5, 2018 Category: Nutrition Source Type: research
