Ginger rhizomes (Zingiber officinale): A spice with multiple health beneficial potentials
This article briefly reviews the most salient investigations which have validated the potential of ginger with respect to the digestive stimulant, protection to the gastrointestinal tract, lipid lowering, anti-obesity, cardioprotective, antidiabetic, anti-inflammatory, and cancer preventive properties. Ginger compounds are potent antioxidants, and consequently, ginger extracts exert promising anti-inflammatory and cancer preventive effects. The most significant among all the nutraceutical attributes of ginger are its positive influence on gastrointestinal tract including digestive stimulant action, anti-inflammatory influe...
Source: PharmaNutrition - January 5, 2017 Category: Nutrition Source Type: research
Characterization of naturally goat cheese enriched in conjugated linoleic acid and omega-3 fatty acids for human clinical trials in overweight and obese subjects
In conclusion, goat diet supplementation seems to improve the nutritional value of the traditional cheese without significant variations in its texture and sensory quality during storage. Thus, this study demonstrates that naturally enriched goat cheese in CLA and omega-3 can meet quality standards with a consistent bioactive lipid pattern for a large human clinical trial focusing on overweight and obese subjects. Graphical abstract (Source: PharmaNutrition)
Source: PharmaNutrition - December 23, 2016 Category: Nutrition Source Type: research
A dietary intervention with non-digestible oligosaccharides and partial hydrolysed whey protein prevents the onset of food allergic symptoms in mice
Publication date: Available online 2 December 2016 Source:PharmaNutrition Author(s): Betty C.A.M. van Esch, Atanaska I. Kostadinova, Johan Garssen, Linette E.M. Willemsen, Léon M.J. Knippels Strategies to prevent food allergy to common food such as cow’s milk are important because there is no causal treatment available yet. Oral tolerance induction is of great importance for allergy prevention which is strongly dependent on allergen exposure and proper immune environment. Improving the efficacy of oral tolerance with adjuvants is a promising new strategy. In the current study, we investigated non-digestible oligo...
Source: PharmaNutrition - December 2, 2016 Category: Nutrition Source Type: research
An olive polyphenol-based nutraceutical improves cutaneous manifestations of psoriasis in humans
In conclusion, we provide the first evidence that a cosmeceutical/nutraceutical formulation based on olive (poly)phenols improve the cutaneous manifestations of psoriasis in patients who are moderately affected by this pathology. The use of supplements as adjuvant therapy of psoriasis could be anticipated. (Source: PharmaNutrition)
Source: PharmaNutrition - November 8, 2016 Category: Nutrition Source Type: research
Production of impure prebiotic galacto-oligosaccharides and their effect on calcium, magnesium, iron and zinc absorption in Sprague-Dawley rats
Publication date: Available online 26 October 2016 Source:PharmaNutrition Author(s): Kaleemullah Maawia, Sanaullah Iqbal, Tahir Rasool Qamar, Pakeeza Rafiq, Azmat ullah, Mansur-ud-Din Ahmad Prebiotic galacto-oligosaccharides (GOS) are important “functional foods” of current scenario and used for various health benefits including improved mineral absorption. In the present study, it was hypothesized that novel GOS mixture, produced through transgalactosylation, with significant amount of mono and disaccharides may enhance mineral absorption in Sprague-Dawley rats. The non-purified GOS having β-(1→6) and β-(1...
Source: PharmaNutrition - October 26, 2016 Category: Nutrition Source Type: research
Propolis induce cytotoxicity on cancerous hepatocytes isolated from rat model of hepatocellular carcinoma: Involvement of ROS-mediated mitochondrial targeting
Publication date: Available online 13 October 2016 Source:PharmaNutrition Author(s): Enayatollah Seydi, Sahar Amir Hosseini, Ahmad Salimi, Jalal Pourahmad Hepatocellular carcinoma (HCC) is the third cause of mortality due to cancer throughout the world. Propolis is a beehive product with a specific chemical composition, widely used in traditional medicine because of its several pharmacological activities. Propolis has attracted much attention in recent years as a useful substance having application in medicine and cosmetics. Many studies have shown that propolis contain anti-cancer compounds. The present research was...
Source: PharmaNutrition - October 13, 2016 Category: Nutrition Source Type: research
Hydroxytyrosol augments the redox status of high fat diet-fed rats
In this study, we assessed whether HT could lessen the metabolic and redox imbalance caused by high-fat diet, in a rat model. Male Wistar rats were divided into four groups (n=4 each), homogeneous for age and weight. Group 1: control diet; Group 2: control diet+20μg HT/d by oral gavage; Group 3: high fat, high carbohydrate diet; Group 4: high fat, high carbohydrate diet+20μg HT/d by oral gavage. The experiment lasted four weeks. The addition of HT to the high fat diet did not slow down weight gain as compared to the unsupplemented diet. No significant differences in glycemia were observed among the four experimental grou...
Source: PharmaNutrition - September 28, 2016 Category: Nutrition Source Type: research
A single intake of a resveratrol-arginine conjugate improves microvascular function compared to trans-resveratrol in postmenopausal women
In this study, we compared the effects of a resveratrol-arginine conjugate (ResArg) to trans-resveratrol (trans-Res), the standard form used in supplements, on measures of microvascular function 1h and 2h after intake. Postmenopausal women were assigned to consume 90mg of resveratrol as either ResArg or t-Res, in a double-blind, randomized, crossover design, at least one week apart. Microvascular function was assessed by peripheral arterial tonometry, and calculated as the reactive hyperemia index (RHI) and the Framingham RHI (fRHI); at 1h, platelet reactivity, plasma resveratrol and nitrate/nitrite levels were also measur...
Source: PharmaNutrition - August 4, 2016 Category: Nutrition Source Type: research
Combination of low dose major n3 PUFAs in fresh water mussel lipid is an alternative of EPA –DHA supplementation in inflammatory conditions of arthritis and LPS stimulated macrophages
This study, for the first time, showed anti-inflammatory potential of lipid from a fresh water species. It has also raised the possibility of the presence of balanced fatty acid combination in a dietary dose, rather than the established EPA–DHA supplement, to be more effective against inflammatory conditions of arthritis and LPS stimulated macrophages. Graphical abstract (Source: PharmaNutrition)
Source: PharmaNutrition - June 17, 2016 Category: Nutrition Source Type: research
Evolution of tryptophan and its foremost metabolites ’ concentrations in milk and fermented dairy products
In this study, we analyzed the concentrations of free TRP, 5-hydroxytryptophan, serotonin, tryptamine, and kynurenine in milks and fermented dairy products at packaging and at their expiration date. TRP concentrations and those of one of its major metabolites, i.e. 5-hydroxytryptophan increase with fermentation whereas those of kynurenine (which has been implicated in the onset of cardiovascular disease and in neurodegeneration) do not differ between milks and their fermented derivatives. Storage has no effect on tryptophan concentrations. The possibility to exploit tryptophan production by dairy cultures and formulate app...
Source: PharmaNutrition - June 17, 2016 Category: Nutrition Source Type: research
Anti-Inflammatory Effects of the Essential Oils of Ginger (Zingiber officinale Roscoe) in Experimental Rheumatoid Arthritis
In this study, anti-inflammatory effects of ginger’s other secondary metabolites, the essential oils (GEO), which contain terpenes with reported phytoestrogenic activity, were assessed in female Lewis rats with SCW-induced arthritis. GEO (28mg/kg/d ip) prevented chronic joint inflammation, but altered neither the initial acute phase of joint swelling nor granuloma formation at sites of SCW deposition in liver. Pharmacologic doses of 17-β estradiol (200 or 600μg/kg/d sc) elicited the same pattern of anti-inflammatory activity, suggesting that GEO could be acting as a phytoestrogen. However, contrary to this hypothesis, ...
Source: PharmaNutrition - June 3, 2016 Category: Nutrition Source Type: research
Acute effects of a resveratrol-arginine conjugate and trans-resveratrol on microvascular function in postmenopausal women
In this study, we compared the effects of a resveratrol-arginine conjugate (ResArg) to trans-resveratrol (trans-Res), the standard form used in supplements, on measures of microvascular function 1h and 2h after intake. Postmenopausal women were assigned to consume 90mg of resveratrol as either ResArg or t-Res, in a double-blind, randomized, crossover design, at least one week apart. Microvascular function was assessed by peripheral arterial tonometry, and calculated as the reactive hyperemia index (RHI) and the Framingham RHI (fRHI); at 1h, platelet reactivity, plasma resveratrol and nitrate/nitrite levels were also measur...
Source: PharmaNutrition - May 30, 2016 Category: Nutrition Source Type: research
Molecular mechanisms of lipid- and glucose-lowering activities of bergamot flavonoids
Publication date: Available online 18 May 2016 Source:PharmaNutrition Author(s): Elzbieta Janda, Antonella Lascala, Concetta Martino, Salvatore Ragusa, Saverio Nucera, Ross Walker, Santo Gratteri, Vincenzo Mollace Bergamot (Citrus bergamia Risso et Poiteau) juice has a particularly high content and a unique composition of flavonoids. Neoeriocitrin, neohesperidin, naringin, melitidin and brutieridin represent more than 95% of Bergamot Polyphenol Fraction (BPF), while rhoifolin, diosmin, poncirin and others can be found in the remaining 5%. The brilliant performance of BPF in clinical practice against as ...
Source: PharmaNutrition - May 18, 2016 Category: Nutrition Source Type: research
The protective role of bergamot polyphenolic fraction on several animal models of pain
Publication date: Available online 8 April 2016 Source:PharmaNutrition Author(s): Filomena Lauro, Sara Ilari, Luigino Antonio Giancotti, Chiara Morabito, Valentina Malafoglia, Micaela Gliozzi, Ernesto Palma, Daniela Salvemini, Carolina Muscoli Bergamot is the common name for Citrus bergamia Risso et Poiteau, a plant belonging to the Rutaceae family (subfamily Esperidea). The trees show big dark green ovate leaves similar to those of lemon, starshaped white flowers and round yellow fruits. In recent years, C. bergamia juice has been raising interest and has been the subject of several studies, consider...
Source: PharmaNutrition - April 8, 2016 Category: Nutrition Source Type: research
Can a healthy life prevent us from post-menopausal osteoporosis? Myths and truths
Publication date: Available online 29 March 2016 Source:PharmaNutrition Author(s): Soledad Herrero, Yolanda Pico Postmenopausal osteoporosis is related to unmodifiable risk factors (genetics, race, gender and age). However, other controllable factors such as activity, body mass, hormone and calcium levels and dietary habits can reduce fracture risk. For example, significant increases in bone mass density have been linked to physical activity in children, supplements of Vitamin C taken for more than 10 years, or high consumption of fish, olive oil or dried plums. This review establishes the scientific basis behind t...
Source: PharmaNutrition - March 28, 2016 Category: Nutrition Source Type: research
