Protective effect of alpha-lipoic acid on progression of cataract formation in fructose-induced experimental cataract
Publication date: December 2017 Source:PharmaNutrition, Volume 5, Issue 4 Author(s): Sajida Begum Khan, Rajesh Choudhary, Prabhat Kumar Vishwakarma, Amrita Singh, Jaya Shree, Surendra H. Bodakhe Cataract is the leading cause of ocular blindness worldwide and exacerbated by various systemic disorders, including diabetes and hypertension. The present study was designed to investigate the protective effects of alpha-lipoic acid (LA) against fructose-induced experimental cataract. Sprague-Dawley albino rats (150–180g) were assigned to groups each containing six animals. Group I (normal) received 0.3% carboxymethyl ce...
Source: PharmaNutrition - October 11, 2017 Category: Nutrition Source Type: research
Food or pharmaceutical? Consumers perception of health-related borderline products
Publication date: Available online 10 October 2017 Source:PharmaNutrition Author(s): Sukhada Khedkar, Laura Carraresi, Stefanie Bröring The aim of this paper is to explore consumer perception of health-related borderline products between food and pharmaceuticals. Such products emerge due to the blurring of boundaries between the food and pharmaceutical industries. They usually fit the description of both food as well as pharmaceuticals to a certain extent. Literature suggests that such products present innovation avenues to companies. However, their ultimate success largely depends on consumers’ perception of their...
Source: PharmaNutrition - October 10, 2017 Category: Nutrition Source Type: research
Protective effect of lipoic acid on progression of cataract formation in fructose-induced experimental cataract
Publication date: Available online 7 October 2017 Source:PharmaNutrition Author(s): Sazida B. Khan, Rajesh Choudhary, Prabhat Kumar Vishwakarma, Amrita Singh, Jaya Shree, Surendra H. Bodakhe Cataract is the leading cause of ocular blindness worldwide and exacerbated by various systemic disorders, including diabetes and hypertension. The present study was designed to investigate the protective effects of lipoic acid against fructose-induced experimental cataract. Sprague-Dawley albino rats (150–180g) were assigned to groups each containing six animals. Group I (normal) received 0.3% carboxymethyl cellulose (10ml/k...
Source: PharmaNutrition - October 8, 2017 Category: Nutrition Source Type: research
Multifunctional biological activities of water extract of housefly larvae (Musca domestica)
In this study, we investigated the usefulness of housefly larvae (Musca domestica) based on their amino acid composition and multifunctional biological activities. First, the utility of the amino acid composition of housefly larvae was evaluated by amino acid analysis. Notably, the housefly larvae contained sufficient amounts of all essential amino acids, and the amino acid composition was similar to that of hen eggs. Second, we prepared housefly larvae water extract (HLWE) using the decoction method and explored the biological activities of the extract for potential application of the extract as a functional food. HLWE sh...
Source: PharmaNutrition - September 24, 2017 Category: Nutrition Source Type: research
Hepatoprotective Effect of Boldine in a Bile Duct Ligated Rat Model of Cholestasis/Cirrhosis
Publication date: Available online 24 July 2017 Source:PharmaNutrition Author(s): Reza Heidari, Leila Moezi, Behnam Asadi, Mohammad Mehdi Ommati, Negar Azarpira Liver fibrosis is a debilitating disease associated with chronic liver injury. Oxidative stress is known as a pivotal mechanism in the initiation and propagation of liver fibrosis. Boldine is a potent antioxidant molecule with several pharmacological effects. The current investigation aimed to evaluate the effect of boldine in bile duct ligated (BDL) rats as a model of cholestasis and cirrhosis. BDL animals received boldine (5, 10, and 20mg/kg/day, oral) for...
Source: PharmaNutrition - July 25, 2017 Category: Nutrition Source Type: research
Antimutagenic and cancer preventive potential of culinary spices and their bioactive compounds
Publication date: Available online 29 June 2017 Source:PharmaNutrition Author(s): Krishnapura Srinivasan Spices significantly contribute to human health through their bioactives. They exert multiple health-beneficial influences including anti-cancer potential. Among natural chemopreventive bioactives capable of inhibiting, retarding, or reversing the multi-stage carcinogenesis, considerable attention has been focused in recent decades on spice derived phytochmicals. Spices with proven anticarcinogenic effects in animal models of cancer include turmeric, garlic, ginger, and black cumin. These spices showed chemopreventiv...
Source: PharmaNutrition - June 29, 2017 Category: Nutrition Source Type: research
Medical doctors ’ perceptions on probiotics: Lack of efficacy data hampers innovation
Conclusion In order to improve the perceptions of MD on probiotics and to advance innovations in this field, more large-scale randomized controlled trials are required that demonstrate probiotic efficacy in adherence with strict Good Clinical Practice guidelines Graphical abstract (Source: PharmaNutrition)
Source: PharmaNutrition - June 28, 2017 Category: Nutrition Source Type: research
Camel milk and its fermented products as a source of potential probiotic strains and novel food cultures: A mini review
Publication date: Available online 24 June 2017 Source:PharmaNutrition Author(s): Amal Bakr Shori Probiotic is a dietary supplement of live microorganism that contributes to the health of the host. The combination of lactic acid bacteria (LAB) and probiotics is widely used in fermented foods such as dairy products. A number of LAB have been isolated and identified as probiotics from the milk of different animal species. Camel milk is considered as health promoting and being consumed widely as a part of the staple diet in some areas of Africa and Asia. Camel milk can be used as a potential source of probiotics in dairy p...
Source: PharmaNutrition - June 24, 2017 Category: Nutrition Source Type: research
Alpha-lipoic acid represses IL-1B and IL-6 through DNA methylation in ovarian cells
Publication date: Available online 23 June 2017 Source:PharmaNutrition Author(s): Simona Dinicola, Myselis Santiago-Reyes, Rita Canipari, Alessandra Cucina, Mariano Bizzarri, Andrea Fuso Alpha-lipoic acid (ALA) is an endogenous molecule with pleiotropic effects, including antioxidant and antiinflammatory activity mediated by NF-kB nuclear factor, that has the potential to regulate pro- and anti-inflammatory cytokines. ALA-induced downregulation of two major pro-inflammatory cytokines, IL-1B and IL-6, has been ascertained in different tissues and experimental models. In pregnant women, ALA-dependent modulation of in...
Source: PharmaNutrition - June 23, 2017 Category: Nutrition Source Type: research
Lutein, a versatile phyto-nutraceutical: An insight on pharmacology, therapeutic indications, challenges and recent advances in drug delivery
Publication date: Available online 9 March 2017 Source:PharmaNutrition Author(s): Tushar Madaan, Andleeb Nikhat Choudhary, Suman Gyenwalee, Shindu Thomas, Harshita Mishra, Mohammad Tariq, Divya Vohora, Sushama Talegaonkar Carotenoids are natural pigments known for their ability to provide protection from ultraviolet radiation and singlet-oxygen-induced damage such as mutation, immunosuppression, and oxidative stress induction. Lutein is a xanthophyll of the carotenoid family and numerous research studies on it have revealed that it is a potential drug candidate for various diseases like age-related macular degene...
Source: PharmaNutrition - March 8, 2017 Category: Nutrition Source Type: research
The anti-inflammatory and antipyretic effects of clove oil in healthy dogs after surgery
Publication date: Available online 28 February 2017 Source:PharmaNutrition Author(s): Vahid Nikoui, Sattar Ostadhadi, Azam Bakhtiarian, Esmaeil Abbasi-Goujani, Saeed Habibian-Dehkordi, Mahshid Rezaei-Roshan, Mehrdad Foroohandeh, Mario Giorgi The current study was designed to evaluate the anti-inflammatory and antipyretic properties of clove oil in dogs. So thirty adult male dogs were used. After a surgical incision on the abdominal area, animals were divided into four group. The first group received 25mg/kg of clove oil while the second group was considered as a control. The third and fourth groups received betam...
Source: PharmaNutrition - February 27, 2017 Category: Nutrition Source Type: research
Carnosine protects brain mitochondria under hyperammonemic conditions: Relevance to hepatic encephalopathy treatment
Publication date: Available online 28 February 2017 Source:PharmaNutrition Author(s): Akram Jamshidzadeh, Hossein Niknahad, Reza Heidari, Mahdi Zarei, Mohammad Mehdi Ommati, Forouzan Khodaei Elevated brain ammonia in hepatic encephalopathy (HE) is a serious and potentially fatal complication. Ammonia-induced oxidative stress, mitochondrial dysfunction, and energy crisis are known as the major mechanisms of ammonia-induced brain injury. Hence, targeting mitochondria seems to be a therapeutic point of intervention in the treatment of HE. Carnosine is abundantly found in human body. Several biological functions includ...
Source: PharmaNutrition - February 27, 2017 Category: Nutrition Source Type: research
Vitamin C Supplementation and Serum Uric Acid: a Reaction to Hyperuricemia and Gout Disease
In conclusion, 500mg vitamin C oral daily dosing might be of the therapeutic value in lowering UA levels in hyperuricemic patients. Graphical abstract (Source: PharmaNutrition)
Source: PharmaNutrition - February 10, 2017 Category: Nutrition Source Type: research
Mushroom nutraceuticals for improved nutrition and better human health: A review
Publication date: Available online 9 February 2017 Source:PharmaNutrition Author(s): Himanshi Rathore, Shalinee Prasad, Satyawati Sharma Mushrooms have always been treasured and appreciated due to their immense role in curing various degenerative diseases. Also their unique taste and flavour make them a demanding food for every man’s plate. Information on their chemical composition, nutritional value and therapeutic properties has expanded dynamically during the last few years. Mushrooms contain 50 to 65% total carbohydrate, 19 to 35% proteins (with various biological and medicinal activities such as lectins) and 2 ...
Source: PharmaNutrition - February 8, 2017 Category: Nutrition Source Type: research
Hepatoprotective and Antioxidant Effects of Fish Oil on Isoniazid-Rifampin Induced Hepatotoxicity in Rats
This study suggests the importance of fish oil as a hepatoprotective and antioxidant dietary supplement, particularly in the patients receiving anti-tubercular therapy which are at a risk of hepatotoxicity. Graphical abstract (Source: PharmaNutrition)
Source: PharmaNutrition - January 24, 2017 Category: Nutrition Source Type: research
