The Passive Avoidance Memory improving Effect of Curcumin in Young Adult Mice: Considering Hippocampal MMP-2, MMP-9 and Akt/GSK3 β
This study aimed to assess the effect of curcumin on passive avoidance memory in adult young mice. Additionally, the hippocampal contents of MMP-2, MMP-9 and Akt/GSK3β were determined. Male mice weighing 20–25 g were trained in passive avoidance apparatus. Curcumin 50 or 100 mg/kg/po (according to our initial tests) or its vehicle was administered for 10 days. On day 10 the training was done and the retention trial was performed 24 hours later. At the complement of behavioral studies, the hippocampal tissue was isolated and western blot analysis was performed for MMP-2, MMP-9 and Akt/GSK3β. The results indicated ...
Source: PharmaNutrition - May 18, 2018 Category: Nutrition Source Type: research
A nutraceutical formulation based on Annurca apple polyphenolic extract is effective on intestinal cholesterol absorption: A randomised, placebo-controlled, crossover study
The objective of the present work was to evaluate the in vitro and clinical effects of a novel nutraceutical product (AMD), formulated with Annurca apple polyphenolic extracts, on the intestinal cholesterol micellar solubility. AMD was able to decrease in vitro cholesterol micellar solubility by about 85.7%, while Nuclear Magnetic Resonance experiments allowed to hypothesize dimeric procyanidins as potential responsible compounds for this effect. Then, a randomised, double blind, single centre, placebo-controlled, crossover study, was designed to evaluate the effect of AMD on the fecal cholesterol excretion. Clinical data ...
Source: PharmaNutrition - May 18, 2018 Category: Nutrition Source Type: research
Diets supplemented with Annona muricata improve the symptoms of fibromyalgia
In this study, the effect of the consumption of Annona muricata L. (Annonaceae) leaves (AM) was investigated on a model for intermittent cold stress (ICS)-induced fibromyalgia in mice. An aqueous extract of AM was investigated in experiments involving 60 five-week-old female mice C57BL/6J. The animals were allocated into six groups (n = 10). Groups (I) Healthy control, (II) ICS control, and (III) ICS + acetaminophen (0.5%), were all fed a standard diet, while groups (IV) and (V) received standard diets supplemented with 15% (AM15) and 30% (AM30) aqueous extract of AM leaves, respectively. Group (VI) received a stan...
Source: PharmaNutrition - May 17, 2018 Category: Nutrition Source Type: research
Sea cucumber (Isostichopus badionotus) body-wall preparations exert anti-inflammatory activity in vivo
Publication date: Available online 27 March 2018 Source:PharmaNutrition Author(s): Leticia Olivera-Castillo, George Grant, Nuvia Kantún-Moreno, Juan J. Acevedo, Marili Puc-Sosa, Jorge Montero, Miguel A. Olvera-Novoa, Elizabeth Negrete, Jesús S. Olalla, Julio Ceballos-Zapata, Mia C.M. Bercansil, Florinia E. Merca, John Lindsay-Edwards, Cesar Puerto-Castillo, Judit Gil-Zamorano, María A. Fernández-Herrera, Mayra Pérez-Tapia, Alberto Dávalos, Rossana Rodriguez-Canul Sea cucumbers contain many bioactive compounds with potential health benefits. Their widespread use in East Asia, in traditional medici...
Source: PharmaNutrition - March 27, 2018 Category: Nutrition Source Type: research
Identification of low molecular weight antimicrobial peptides from Iraqi camel milk fermented with Lactobacillus plantarum
In this study, fermented camel milk was investigated for antibacterial activity. The milk was pasteurized at 90 °C for 30 a minute period, cooled down to 42 °C and inculcated with Lactobacillus plantarum, and incubated at 42 °C for 24 h. The fermented milk was fractionated by RP-HPLC in order to determine the antibacterial activity, and also to identify the peptides by LC-MS/MS. The antimicrobial activity of the fractionated peptides was tested against Staphylococcus faecalis, Shigella dysenteriae, Staphylococcus aureus and E. coli. Fraction 14 demonstrated the highest antimicrobial activity, and contained 32 pe...
Source: PharmaNutrition - March 9, 2018 Category: Nutrition Source Type: research
Production of fermented skim milk supplemented with different grape pomace extracts: effect on viability and acidification performance of probiotic cultures
In this study, probiotic fermented skim milk was supplemented with pomace extracts obtained from Pinot Noir, Freisa, Croatina and Barbera grape varieties. Regarding acidification kinetics, the addition of Pinot Noir extract increased the maximum acidification rate (Vmax) of skim milk by 39.4% compared with control (no pomace extract supplementation). The time required to complete the fermentation (tpH4.5 = 3.5 h) was shortened when grape pomace extracts were added to the fermented skim milk. It was also observed that after 28 days of storage at 4 °C, polyphenolic compound supplementations had a positive effect o...
Source: PharmaNutrition - March 5, 2018 Category: Nutrition Source Type: research
Hybrid business models for ‘Organ-on-a-Chip’ technology: the best of both worlds
Publication date: Available online 17 February 2018 Source:PharmaNutrition Author(s): Linda H.M. van de Burgwal, Pim van Dorst, Henk Viëtor, Regina Luttge, Eric Claassen Current in vitro and in vivo preclinical models often have limited predictive value for translation to the clinical setting. The emerging ‘Organ-on-a-Chip’ (OOC) technology provides a better resemblance to the human physiology through combining 3D configuration of human-derived cells with microfluidic techniques, potentially improving translation. However, due to the disruptive nature of the OOC technology, it is unclear how to best achieve a p...
Source: PharmaNutrition - February 18, 2018 Category: Nutrition Source Type: research
Corrigendum to ‘An olive polyphenol-based nutraceutical improves cutaneous manifestations of psoriasis in humans’ PharmaNutrition 4 (2016) 151–153
Publication date: March 2018 Source:PharmaNutrition, Volume 6, Issue 1 Author(s): E. Herrera Acosta, J. Alonso Suárez Pérez, J. Aguilera Arjona, F. Visioli (Source: PharmaNutrition)
Source: PharmaNutrition - February 9, 2018 Category: Nutrition Source Type: research
Emerging role of Branched Chain Amino Acids in Metabolic Disorders: A mechanistic review
Publication date: Available online 5 February 2018 Source:PharmaNutrition Author(s): A. Rohini, Neeraj Agrawal, Harish Kumar, Vipin Kumar Branched-chain amino acids (BCAAs) belong to the group of essential amino acids having diverse physiological and metabolic roles. The controversy regarding impact of BCAAs supplements in improving the metabolic health still remains in spite of the sufficient understanding regarding pathogenesis of metabolic disorders. Several basic and clinical studies have advocated the use of BCAAs, besides that, a high risk of metabolic disorders, type 2 diabetes mellitus (T2DM) and insulin resi...
Source: PharmaNutrition - February 6, 2018 Category: Nutrition Source Type: research
Comparative study of antihypertensive and antioxidant effects of clove and metformin on renal dysfunction in streptozotocin-induced diabetic rats
Publication date: March 2018 Source:PharmaNutrition, Volume 6, Issue 1 Author(s): Guenzet Akila, Krouf Djamil, Dida Nawal, Berzou Saadia The effect of exposure to diabetes on the kidney appears to be modulated by elevated level of oxidative stress and increased blood pressure. We used streptozotocin-induced diabetes in rats to further explore the importance of renal dysfunction associated with oxidative status and hypertension and the modulatory anti-hyperglycemic effects of clove in comparison with metformin against kidney injury. Diabetes was induced intraperitonially by a single injection of streptozotocin (55 m...
Source: PharmaNutrition - February 6, 2018 Category: Nutrition Source Type: research
Claimed effects, outcome variables and methods of measurement for health claims proposed under Regulation (EC) 1924/2006 in the framework of bone health
Publication date: March 2018 Source:PharmaNutrition, Volume 6, Issue 1 Author(s): Daniela Martini, Cristina Guareschi, Beatrice Biasini, Giorgio Bedogni, Carlo Galli, Donato Angelino, Laura Marchi, Ivana Zavaroni, Carlo Pruneti, Marco Ventura, Daniela Galli, Prisco Mirandola, Marco Vitale, Alessandra Dei Cas, Riccardo C. Bonadonna, Giovanni Passeri, Daniele Del Rio Several foods or food components have been the object of application for authorization of health claims on bone health, pursuant to Regulation (EC) 1924/2006. For most of them, the European Food Safety Authority (EFSA) has issued negative opin...
Source: PharmaNutrition - December 29, 2017 Category: Nutrition Source Type: research
Dietary supplementation with Ethiopian pepper (Xylopia aethiopica) modulates angiotensin-I converting enzyme activity, antioxidant status and extenuates hypercholesterolemia in high cholesterol fed Wistar rats
Publication date: Available online 12 November 2017 Source:PharmaNutrition Author(s): Stephen A. Adefegha, Ganiyu Oboh, Tosin A. Olasehinde, Aline A. Boligon The lipid lowering, antihypertensive, hepatoprotective and antioxidant activities of Ethiopian pepper (Xylopia aethiopica) supplemented diet in hypercholesterolemic rats were investigated in this study. Animals were divided into five groups (n=7); normal control rats (NC); untreated hypercholeterolemic rats (Hyper-C diet); hypercholesterolemic rats treated with oral dose of 1mg/kg of simvastatin (Hyper-C diet+STATIN); hypercholesterolemic rats treated with 2% (H...
Source: PharmaNutrition - November 12, 2017 Category: Nutrition Source Type: research
Anonna muricata L. (soursop) seed oil improves type 1 diabetes parameters in vivo and in vitro
In this study, we identified the immunomodulatory potential of A. muricata seed oil (AmSO) in streptozotocin (STZ)-induced in vivo and in vitro experimental model of T1D and whole blood cell culture from diabetic patients. AmSO cytotoxicity was evaluated by MTT-tetrazolium and resazurin. AmSO was orally administered to BALB/c mice for 48days and were divided into groups: control, STZ (diabetic), STZ–AmSO (diabetic, treated with 1.0mg/kg AmSO), and AmSO groups (nondiabetic, treated with 1.0mg/kg AmSO). T1D was induced with intraperitoneal administration of STZ (3×100mg/Kg). Biochemistry and histopathological analysis and...
Source: PharmaNutrition - November 10, 2017 Category: Nutrition Source Type: research
N-acetylcysteine treatment blunts liver failure-associated impairment of locomotor activity
This study aimed to evaluate the effect of NAC supplementation on liver failure-associated locomotor activity impairment and oxidative stress in the brain. Mice received acetaminophen (APAP; 800mg/kg, i.p) and plasma biochemical parameters, plasma, and brain ammonia level, and animals’ locomotor activity were monitored. Moreover, brain tissue markers of oxidative stress were measured. It was found that plasma and brain ammonia was increased, and markers of liver injury were significantly elevated in the APAP-treated group. Impaired locomotor activity was also detected in APAP group. Moreover, an increase in markers of ox...
Source: PharmaNutrition - November 3, 2017 Category: Nutrition Source Type: research
Food or pharmaceuticals? Consumers' perception of health-related borderline products
Publication date: December 2017 Source:PharmaNutrition, Volume 5, Issue 4 Author(s): Sukhada Khedkar, Laura Carraresi, Stefanie Bröring The aim of this paper is to explore consumers' perception of health-related borderline products between food and pharmaceuticals. Such products emerge due to blurring of boundaries between the food and pharmaceutical industries. They fit the description of both food and pharmaceuticals to a certain extent. Literature suggests that such products present innovation avenues to companies. However, their ultimate success largely depends on consumers’ perception of their safety, efficacy...
Source: PharmaNutrition - November 3, 2017 Category: Nutrition Source Type: research
