Comparative study of antihypertensive and antioxidant effects of clove and metformin on renal dysfunction in streptozotocin-induced diabetic rats

Publication date: March 2018 Source:PharmaNutrition, Volume 6, Issue 1 Author(s): Guenzet Akila, Krouf Djamil, Dida Nawal, Berzou Saadia The effect of exposure to diabetes on the kidney appears to be modulated by elevated level of oxidative stress and increased blood pressure. We used streptozotocin-induced diabetes in rats to further explore the importance of renal dysfunction associated with oxidative status and hypertension and the modulatory anti-hyperglycemic effects of clove in comparison with metformin against kidney injury. Diabetes was induced intraperitonially by a single injection of streptozotocin (55 mg/kg bw). One untreated diabetic group (D) consumed 20% casein and drinks only water, whereas the two other groups consumed the same diet and received either Syzygium aromaticum extract dissolved in water (D-Sa) by gavage or a glucophage MTF dissolved in water (D-MTF), for 4 weeks. The injection of streptozotocin in rats leads to increases blood pressure, alteration in the redox state of the kidney and electrolytic imbalance. However, administration of clove or metformin reduces blood pressure, serum sodium and increases potassium level. Histology analysis revealed several glomerular and tubule-interstitial alterations were effectively reduced by treatment with both clove and metformin. The renoprotective effect induced by these drugs was due to modulation of oxidative status. The present study, thereby demonstrates the hypotensive and renoprotective effects...
Source: PharmaNutrition - Category: Nutrition Source Type: research