Sea cucumber (Isostichopus badionotus) body-wall preparations exert anti-inflammatory activity in vivo

Publication date: Available online 27 March 2018 Source:PharmaNutrition Author(s): Leticia Olivera-Castillo, George Grant, Nuvia Kantún-Moreno, Juan J. Acevedo, Marili Puc-Sosa, Jorge Montero, Miguel A. Olvera-Novoa, Elizabeth Negrete, Jesús S. Olalla, Julio Ceballos-Zapata, Mia C.M. Bercansil, Florinia E. Merca, John Lindsay-Edwards, Cesar Puerto-Castillo, Judit Gil-Zamorano, María A. Fernández-Herrera, Mayra Pérez-Tapia, Alberto Dávalos, Rossana Rodriguez-Canul Sea cucumbers contain many bioactive compounds with potential health benefits. Their widespread use in East Asia, in traditional medicines and as food supplements, are depleting many local stocks and thus increasing their harvest worldwide. In recent years this has included heavy fishing of Isostichopus badionotus from the Yucatan Peninsula. The bioactivities in sea cucumber are known to vary greatly with species and growth conditions. Despite this, little study has been done on the capacity of I. badionotus captured from Yucatan to modulate health in vivo. Sea cucumbers were harvested from the Yucatan coast and body wall prepared, freeze dried and ground. The anti-inflammatory properties were evaluated using a hen’s egg test – chorioallantoic membrane (HET-CAM) assay, a rat feeding trial, and with a mouse ear inflammation model. Additional analysis was done by histology and qRT-PCR. Extracts of lyophilized I. badionotus exerted a strong anti-inflammatory activity in each of the assays....

Source: PharmaNutrition - March 27, 2018 Category: Nutrition Source Type: research