Distinct capability of some fats on unsaturated fatty acid and antioxidant enrichment of foods for ketogenic diet purpose
Publication date: Available online 29 March 2016 Source:PharmaNutrition Author(s): Csaba Orbán, Kinga Katalin Horváth, Erzsébet Mák, Adrienn Lichthammer, Márta Veresné-Bálint Ketogenic diet is a dietetic approach for the treatment of refractory childhood epilepsy. In this experiment we aimed to assess the total lipid content enrichment capability of different however, less studied fats, as well as the possibilities to transfer unsaturated fatty acids and antioxidants into different foods, as these substances proved to be relevant in the mechanism of the ketogenic diet. We also determined the stability ...
Source: PharmaNutrition - March 28, 2016 Category: Nutrition Source Type: research
Bergamot polyphenolic fraction counteracts erectile dysfunction occurring in patients suffering from type 2 diabetes
Publication date: Available online 11 March 2016 Source:PharmaNutrition Author(s): Vincenzo Mollace, Natalia Malara, Santo Gratteri, Ernesto Palma, Luca Zappia, Nicola Costa, Giuseppe Rosano Erectile dysfunction (ED) is a complex disease occurring mainly in patients with metabolic disorders including Diabetes Mellitus and Metabolic syndrome. It correlates with an increased occurrence of cardiovascular disorders including coronary artery disease and heart failure. Alongside with the development of inhibitors of 5-PDE (sildenafil, tadalafil etc.), many medicinal plants used in traditional medicine have been...
Source: PharmaNutrition - March 12, 2016 Category: Nutrition Source Type: research
The effects of short-chain fatty acids on the cardiovascular system
Publication date: Available online 7 March 2016 Source:PharmaNutrition Author(s): L.B. Richards, M. Li, B.C.A.M. van Esch, J. Garssen, G. Folkerts The development of cardiovascular diseases is often attributable to loss of endothelial functions of the vascular tissue or to decreased contractile function of the heart muscle. These disturbances are often caused by imbalances in lipid and glucose metabolism. For instance, these imbalances can result in a low-grade inflammatory state of affected endothelial tissue, causing macrophages and fat-rich lipoproteins to accumulate in the subendothelial space. Short-chai...
Source: PharmaNutrition - March 7, 2016 Category: Nutrition Source Type: research
Omega-3 fatty acids combined with aripiprazole and lithium modulates activity of mitochondrial enzymes and acetylcholinesterase in methylphenidate-induced animal model of mania
Publication date: Available online 7 March 2016 Source:PharmaNutrition Author(s): Pandiyan Arunagiri, Elumalai Balamurugan Many studies have shown the alterations of mitochondrial complexes in bipolar disorder (BD) patients. However, changes in the Krebs cycle enzymes have been little studied.The animal model of mania induced by psychostimulants like amphetamine and methylphenidate (MPD) has been widely used to study the manic phase of bipolar disorder. The aim of the present study is to assess the changes in the activity of Krebs cycle enzymes and acetylcholinesterase (AChE) in an animal model of mania induced by ...
Source: PharmaNutrition - March 7, 2016 Category: Nutrition Source Type: research
Evolution of tryptophan and its foremost metabolites’ concentrations in milk and fermented dairy products
In this study, we analyzed the concentrations of free TRP, 5-hydroxytryptophan, serotonin, tryptamine, and kynurenine in milks and fermented dairy products at packaging and at their expiration date. TRP concentrations and those of one of its major metabolites, i.e. 5-hydroxytryptophan increase with fermentation whereas those of kynurenine (which has been implicated in the onset of cardiovascular disease and in neurodegeneration) do not differ between milks and their fermented derivatives. Storage has no effect on tryptophan concentrations. The possibility to exploit tryptophan production by dairy cultures and formulate app...
Source: PharmaNutrition - March 4, 2016 Category: Nutrition Source Type: research
Bergamot polyphenolic fraction counteracts photoageing in human keratinocytes
Publication date: Available online 4 December 2015 Source:PharmaNutrition Author(s): Steven Paul Nisticò, Ugo Bottoni, Micaela Gliozzi, James Ehrlich, Massimo Fini Photoageing represents the addition of extrinsic chronic ultraviolet radiation induced damage on intrinsic ageing and accounts for most age-associated changes in skin appearance. The skin contains numerous endogenous antioxidants to help provide protection from reactive oxidative species generated during normal cellular metabolism. However, overexposure to UV radiation can lead to a significant reduction in the antioxidant supply accompanied by an...
Source: PharmaNutrition - December 5, 2015 Category: Nutrition Source Type: research
Medicinal plants of the genuses Salvia and Hypericum are sources of anticolon cancer compounds: effects on PI3K/Akt and MAP Kinases pathways
Publication date: Available online 1 December 2015 Source:PharmaNutrition Author(s): Cristina P.R. Xavier, Cristina Pereira-Wilson Colorectal cancer (CRC) is the third most prevalent cancer worldwide and the incidence is highly influenced by diet. Epidemiological studies have supported the idea that some medicinal plants may influence the risk of CRC through modulation of several biological processes, including proliferation, survival and cell death. The PI3K/Akt and MAP Kinases pathways are frequently constitutively activated in CRC and components of these pathways are important molecular targets for CRC treatment...
Source: PharmaNutrition - December 1, 2015 Category: Nutrition Source Type: research
Crossing industrial boundaries at the pharma-nutrition interface in probiotics: a life cycle perspective
Publication date: Available online 1 December 2015 Source:PharmaNutrition Author(s): Sabine Bornkessel, Stefanie Bröring, S.W.F. (Onno) Omta The aim of this paper is to advance the research on innovation at the pharma-nutrition interface by analysing the three steps of science, technology and market convergence in the area of probiotics using a life cycle perspective. Results from a bibliometric analysis drawing upon 8245 scientific publications, 2082 patents and 1357 news reports focussing on product launch announcements from 1990 up to 2009 indicate that the proposed curve shapes of the life cycles in the theo...
Source: PharmaNutrition - December 1, 2015 Category: Nutrition Source Type: research
The effect of bergamot polyphenolic fraction in patients with non alcoholic liver steato-hepatitis and metabolic syndrome
Publication date: Available online 26 November 2015 Source:PharmaNutrition Author(s): Micaela Gliozzi, Jessica Maiuolo, Francesca Oppedisano, Vincenzo Mollace The occurrence of Metabolic Syndrome (MS) represents an independent risk factor for developing cardiovascular disease states in patients suffering from type 2 diabetes mellitus. Moreover, both the size of LDL particles and liver dysfunction identified as non alcoholic steato-hepatitis (NASH) represent important biomarkers for the development of cardiometabolic risk in patients with MS. Recent evidence shows that bergamot polyphenolic fraction (BPF) in pat...
Source: PharmaNutrition - November 27, 2015 Category: Nutrition Source Type: research
Studies on the protective role of Bergamot polyphenols in doxorubicin-induced cardiotoxicity
Publication date: Available online 27 November 2015 Source:PharmaNutrition Author(s): Cristina Carresia, Micaela Gliozzia, Caterina Giancottaa, Antonino Scarcellaa, Federica Scaranoa, Francesca Boscoa, Rocco Mollacea, Annamaria Tavernesea, Cristiana Vitalea, Vincenzo Musolinoa Doxorubicin (DOXO) is one of the most widely used and successful antineoplastic drugs in treating hematologic cancers and malignant neoplasms in both adults and children, however, its clinical use is seriously limited due to the development of acute and chronic cardiotoxicity leading to cardiomyopathy and congestive heart fail...
Source: PharmaNutrition - November 27, 2015 Category: Nutrition Source Type: research
Characterization of flavonoids in Citrus bergamia (Bergamot) polyphenolic fraction by liquid chromatography-high resolution mass spectrometry (LC/HRMS)
Publication date: Available online 12 November 2015 Source:PharmaNutrition Author(s): Raffaele Salerno, Francesca Casale, Carla Calandruccio, Antonio Procopio The goal of the present study was the development of a UHPLC-HRMS/MS method for the identification of flavonoids present in BPF (bergamot polyphenolic fraction), a particular product derived from Bergamot juice. BPF contains over 40% flavonoids and the remaining 60% are carbohydrates, fatty acids, pectins and other compounds as well as maltodextrins which are added to allow exsiccation. Trademark and patent No.0001380456 by Herbal and Antioxidant Derivati...
Source: PharmaNutrition - November 12, 2015 Category: Nutrition Source Type: research
Health ingredients research at a crossroads
Publication date: July 2015 Source:PharmaNutrition, Volume 3, Issue 3 Author(s): Yves Pouliot (Source: PharmaNutrition)
Source: PharmaNutrition - October 26, 2015 Category: Nutrition Source Type: research
Patient needs and research priorities in probiotics: A quantitative KOL prioritization analysis with emphasis on infants and children
This study aimed to systematically prioritize the unmet needs and research opportunities in infants, children, adults and elderly for probiotics according to their relative importance from a key-opinion-leader (KOL) perspective. In addition, it reveals potential probiotic product characteristics that need improvement from both a patient or consumer and a KOL perspective. Moreover, KOL involvement in the probiotic research & development (R&D) process was assessed. Data was collected by conducting semi-structured interviews and subsequent online questionnaires. The three clinical indications requiring the hig...
Source: PharmaNutrition - October 1, 2015 Category: Nutrition Source Type: research
A quantitative key-opinion-leader analysis of innovation barriers in probiotic research and development: valorisation and improving the tech transfer cycle
This study demonstrates that the probiotic research cycle is faulty due to specific barriers and bypasses, and that innovation is hampered in all domains of the valorisation cycle. Eleven main barriers were identified, with “difficulty in demonstrating clinical efficacy” being the most significant inhibiting factor. Other barriers could be classified as fundamental research barriers, clinical research barriers, financial barriers, regulatory barriers, collaboration barriers, marketing barriers and product barriers. Using this barrier approach, inhibiting factors are identified which allows subsequent action to be taken...
Source: PharmaNutrition - September 26, 2015 Category: Nutrition Source Type: research
Highly bioavailable curcumin (Theracurmin): its development and clinical application
Publication date: Available online 11 September 2015 Source:PharmaNutrition Author(s): Atsushi Imaizumi Curcumin is a polyphenol with antioxidant and anti-inflammatory properties. It is highly lipophilic and sparingly soluble in water and very little is absorbed when it is ingested; therefore, improving its absorbability is a major priority. We developed a highly bioavailable curcumin called Theracurmin using submicron particle formation and surface controlled technology. In human study, the area under the blood concentration–time curve (AUC) after oral administration of Theracurmin was 27-fold higher than that of ...
Source: PharmaNutrition - September 12, 2015 Category: Nutrition Source Type: research
