Acute effects of a resveratrol-arginine conjugate and trans-resveratrol on microvascular function in postmenopausal women

In this study, we compared the effects of a resveratrol-arginine conjugate (ResArg) to trans-resveratrol (trans-Res), the standard form used in supplements, on measures of microvascular function 1h and 2h after intake. Postmenopausal women were assigned to consume 90mg of resveratrol as either ResArg or t-Res, in a double-blind, randomized, crossover design, at least one week apart. Microvascular function was assessed by peripheral arterial tonometry, and calculated as the reactive hyperemia index (RHI) and the Framingham RHI (fRHI); at 1h, platelet reactivity, plasma resveratrol and nitrate/nitrite levels were also measured. A significant increase in fRHI was observed 1h after intake of ResArg compared to trans-Res. Significant reductions in platelet reactivity were noted 1h after ResArg intake, but not for trans-Res. Plasma resveratrol levels were increased 30 and 60min after the consumption of both ResArg and t-Res. The results suggest a more rapid and pronounced response from ResArg than trans-Res on certain markers of vascular function. Graphical abstract

Source: PharmaNutrition - May 30, 2016 Category: Nutrition Source Type: research