Jaboticaba peel extract supress autophagy in white adipose tissue and prevents metabolic disorders in mice fed with a high-fat diet

Publication date: Available online 30 June 2018 Source:PharmaNutrition Author(s): Andressa Mara Baseggio, Carla Evelyn Coimbra Nuñez, Nathalia Romanelli Vicente Dragano, Celina Almeida Lamas, Patrícia Aparecida de Campos Braga, Sabrina Alves Lenquiste, Felix Guillermo Reyes Reyes, Valéria Helena Alves Cagnon, Mário Roberto Maróstica Júnior The increase in autophagy markers in the white adipose tissue is associated with adipocyte hypertrophy and obesity physiopathology. The jaboticaba peel is rich in bioactive compounds as polyphenols, which have been demonstrating anti-oxidant and inflammatory effects, and possibly interferes in adipose tissue metabolism and obesity. Thus, this study aimed to evaluate the effects of jaboticaba peel extract (FJE) treatment in autophagy markers of epididymal and inguinal white adipose tissue (eWAT and iWAT) of mice fed a normocaloric or high-fat diet for 6 weeks. The FJE treatment modulates autophagy markers in the eWAT of animals fed a high-fat diet by the reduction of Beclin-1 and LC3BII, and an increase in SQSTM-p62, accompanied by a decrease in tissue and total body weight, indicating the importance of autophagy in obesity development. These alterations were not followed by lower cytokines concentration, suggesting that autophagy may be fundamental to adipocyte remodeling at the beginning of adipocyte hypertrophy, before the onset of low-grade inflammation. Furthermore, the treatment reduced total serum triglycerides and fa...
Source: PharmaNutrition - Category: Nutrition Source Type: research