Association between DPP4 gene polymorphism and serum lipid levels in Chinese type 2 diabetes individuals
The goal of the genetic investigation was to identify the associations of serum lipid levels and DPP-4 variants in Chinese type 2 diabetes patients. (Source: Neuropeptides)
Source: Neuropeptides - August 15, 2016 Category: Neuroscience Authors: Xiaomin Xing, Yi Han, Xiaojun Zhou, Bo Zhang, Yan Li, Zhongsu Wang, Lin Liao, Lequn Su Source Type: research
Apelin-13 protects neurovascular unit against ischemic injuries through the effects of vascular endothelial growth factor
Apelin-13 has protective effects on many neurological diseases, including cerebral ischemia. Here, we aimed to test Apelin-13's effects on ischemic neurovascular unit (NVU) injuries and investigate whether the effects were dependent on vascular endothelial growth factor (VEGF). We detected the expression of VEGF and its receptors (VEGFRs) induced by Apelin-13 injection at 1d, 3d, 7d and 14d after middle cerebral artery occlusion (MCAO). Meanwhile, we examined the effects of Apelin-13 on NVU in both in vivo and in vitro experiments as well as whether the effects were VEGF dependent by using VEGF antibody. (Source: Neuropeptides)
Source: Neuropeptides - August 15, 2016 Category: Neuroscience Authors: Chuyi Huang, Chuanfu Dai, Kai Gong, Huancong Zuo, Heling Chu Source Type: research
Nonsulfated cholecystokinins in cerebral neurons
Cholecystokinin (CCK) is a widely expressed neuropeptide system originally discovered in the gut. Both cerebral and peripheral neurons as well as endocrine I-cells in the small intestine process proCCK to tyrosyl-O-sulfated and α-carboxyamidated peptides. Recently, we reported that gut endocrine I-cells also synthetize nonsulfated CCK in significant amounts. Accordingly, we have now examined whether porcine and rat cerebral tissues (four cortical regions, hypothalamus and cerebellum) also synthesize nonsulfated CCK. (Source: Neuropeptides)
Source: Neuropeptides - August 9, 2016 Category: Neuroscience Authors: Mikkel Agersnap, Ming-Dong Zhang, Tibor Harkany, Tomas H ökfelt, Jens F. Rehfeld Source Type: research
Association study of two functional single nucleotide polymorphisms of neuropeptide y gene with multiple sclerosis
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by brain inflammation, demyelination and axonal loss. Neuropeptide Y (NPY) has a critical role in the maintenance of homeostasis in the immune system and coping of stress condition. In current study we analyzed 188 patients suffering from MS and 204 unrelated healthy controls for two functional single nucleotide polymorphisms (SNPs), NPY _20T>C (rs16139) and NPY _-485T>C (rs16147) using PCR-RFLP and Mismatch PCR-RFLP methods. (Source: Neuropeptides)
Source: Neuropeptides - August 7, 2016 Category: Neuroscience Authors: Seyed Mahdi Mohammadi, Zeinab Shirvani Farsani, Rozita Dosti, Mohammad Ali Sahraian, Mehrdad Behmanesh Source Type: research
The Effect Of Leptin, Ghrelin, And Neuropeptide-Y On Serum Tnf- Α, Il-1β, Il-6, Fgf-2, Galanin Levels and Oxidative Stress In An Experimental Generalized Convulsive Seizure Model
The objective of this study is to examine the effects of the endogenous ligands leptin, ghrelin, and neuropeptide Y (NPY) on seizure generation, the oxidant/antioxidant balance, and cytokine levels, which are a result of immune response in a convulsive seizure model. With this goal, Wistar rats were divided into 5 groups —Group 1: Saline, Group 2: Saline + PTZ (65mg/kg), Group 3: leptin (4mg/kg)+PTZ, Group 4: ghrelin (80μg/kg)+PTZ, and Group 5: NPY (60μg/kg)+PTZ. All injections were delivered intraperitoneally, and simultaneous electroencephalography (EEG) records were obtained. (Source: Neuropeptides)
Source: Neuropeptides - August 5, 2016 Category: Neuroscience Authors: Berrin Oztas, Deniz Sahin, Hale Kir, Fatma Ceyla Eraldemir, Mert Musul, Sevin ç Kuskay, Nurbay Ates Source Type: research
