Chronic adriamycin treatment impairs CGRP-mediated functions of meningeal sensory nerves
Adriamycin is a potent anthracycline-type antitumor agent, but it also exerts potentially serious side effects due to its cardiotoxic and neurotoxic propensity. Multiple impairments in sensory nerve functions have been recently reported in various rat models. The present experiments were initiated in an attempt to reveal adriamycin-induced changes in sensory effector functions of chemosensitive meningeal afferents.Meningeal blood flow was measured with laser Doppler flowmetry in the parietal dura mater of adult male Wistar rats. (Source: Neuropeptides)
Source: Neuropeptides - April 9, 2018 Category: Neuroscience Authors: Éva Deák, Judit Rosta, Krisztina Boros, Gyöngyi Kis, Péter Sántha, Karl Messlinger, Gábor Jancsó, Mária Dux Source Type: research
Hypothalamic peroxisome proliferator-activated receptor gamma regulates ghrelin production and food intake
Peroxisome proliferator-activated receptor- γ (PPARγ) regulates fatty acid storage, glucose metabolism, and food intake. Ghrelin, a gastric hormone, provides a hunger signal to the central nervous system to stimulate appetite. However, the effects of PPARγ on ghrelin production are still unclear. In the present study, the effects of PPARγ on ghrelin production were examined in lean- or high-fat diet-induced obese (DIO) C57BL/6J mice and mHypoE-42 cells, a hypothalamic cell line. 3rd intracerebroventricular injection of adenoviral-directed overexpression of PPARγ (Ad-PPARγ) reduced hypothalamic and plasma ghrelin, foo...
Source: Neuropeptides - April 9, 2018 Category: Neuroscience Authors: Qingjie Li, Quan Yu, Li Lin, Heng Zhang, Miao Peng, Chunxia Jing, Geyang Xu Source Type: research
Chronic adriamycin treatment impairs CGRP-mediated functions of meningeal sensory nerves
Adriamycin is a potent anthracycline-type antitumor agent, but it also exerts potentially serious side effects due to its cardiotoxic and neurotoxic propensity. Multiple impairments in sensory nerve functions have been recently reported in various rat models. The present experiments were initiated in an attempt to reveal adriamycin-induced changes in sensory effector functions of chemosensitive meningeal afferents.Meningeal blood flow was measured with laser Doppler flowmetry in the parietal dura mater of adult male Wistar rats. (Source: Neuropeptides)
Source: Neuropeptides - April 9, 2018 Category: Neuroscience Authors: Éva Deák, Judit Rosta, Krisztina Boros, Gyöngyi Kis, Péter Sántha, Karl Messlinger, Gábor Jancsó, Mária Dux Source Type: research
Hypothalamic peroxisome proliferator-activated receptor gamma regulates ghrelin production and food intake
Peroxisome proliferator-activated receptor- γ (PPARγ) regulates fatty acid storage, glucose metabolism, and food intake. Ghrelin, a gastric hormone, provides a hunger signal to the central nervous system to stimulate appetite. However, the effects of PPARγ on ghrelin production are still unclear. In the present study, the effects of PPARγ on ghrelin production were examined in lean- or high-fat diet-induced obese (DIO) C57BL/6J mice and mHypoE-42 cells, a hypothalamic cell line. 3rd intracerebroventricular injection of adenoviral-directed overexpression of PPARγ (Ad-PPARγ) reduced hypothalamic and plasma ghrelin, foo...
Source: Neuropeptides - April 9, 2018 Category: Neuroscience Authors: Qingjie Li, Quan Yu, Li Lin, Heng Zhang, Miao Peng, Chunxia Jing, Geyang Xu Source Type: research
Orexin-A and endocannabinoid signaling regulate glucose-responsive arcuate nucleus neurons and feeding behavior in obese rats
In this study, we attempted to analyze effects of orexin-A and endocannabinoid signaling modulation in the arcuate nucleus (Arc) on feeding and glucose-responsive (GR) neurons physiology in a diet-induced obesity (DIO) and diet-induced obesity resistant (DR) rat model. Administration of orexin-A or cannabinoid receptor type-1 (CB1R) antagonist AM251 altered the firing of GR neurons in the Arc. (Source: Neuropeptides)
Source: Neuropeptides - April 5, 2018 Category: Neuroscience Authors: Dandan Yang, Luo Xu, Feifei Guo, Xiangrong Sun, Di Zhang, Mi Wang Source Type: research
Effects of intrathecal administration of orexin-1 receptor antagonist on antinociceptive responses induced by chemical stimulation of lateral hypothalamus in an animal model of tonic nociception
This study was carried out to investigate the effects of intrathecal administration of orexin-1 receptor antagonist (SB-334867) in the spinal antinociception induced by intra-LH administration of carbachol (cholinergic receptor agonist) in both early and late phases of pain related behaviors in formalin test. (Source: Neuropeptides)
Source: Neuropeptides - April 3, 2018 Category: Neuroscience Authors: Laleh Rezaee, Saeideh Karimi-Haghighi, Soheila Fazli-Tabaei, Abbas Haghparast Source Type: research
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(Source: Neuropeptides)
Source: Neuropeptides - April 1, 2018 Category: Neuroscience Source Type: research
Appetite-associated responses to central neuropeptide Y injection in quail
The appetite-associated effects of neuropeptide Y (NPY) have been extensively studied in mammalian models. Less knowledge exists for other vertebrate species including birds. The aim of this study was to determine the effects of central injection of NPY on feeding behavior and hypothalamic physiology in 7 day-old Japanese quail (Coturnix japonica). During the light cycle, intracerebroventricular injection of 1.9 pmol, 0.5, and 1.0 nmol doses of NPY did not affect food intake, 0.031 to 0.13 nmol increased food intake, and 2.0 nmol NPY decreased food intake, in comparison to vehicle injectio n. (Source: Neuropeptides)
Source: Neuropeptides - March 8, 2018 Category: Neuroscience Authors: Betty R. McConn, Elizabeth R. Gilbert, Mark A. Cline Source Type: research
Cellular effects of AP102, a somatostatin analog with balanced affinities for the hSSTR2 and hSSTR5 receptors
Somatostatin analogs (SSAs) are first-line medical therapy for the treatment of acromegaly and neuroendocrine tumors that express somatostatin receptors (SSTR). Somatostatin suppresses secretion of a large number of hormones through the stimulation of the five SSTR. However, unbalanced inhibition of secretion as observed with the highly potent SSAs pasireotide causes hyperglycaemia mainly by inhibiting insulin secretion. In contrast, AP102 a new SSAs has neutral effect on blood glucose while suppressing GH secretion. (Source: Neuropeptides)
Source: Neuropeptides - March 1, 2018 Category: Neuroscience Authors: Jeremy Streuli, Alan G. Harris, Cecilia Cottiny, Florent Allagnat, Adrian F. Daly, Eric Grouzmann, Karim Abid Source Type: research
Role of neuropeptide Y (NPY) in the differentiation of Trpm-5-positive olfactory microvillar cells
The mouse olfactory neuroepithelium (ON) is comprised of anatomically distinct populations of cells in separate regions; apical (sustentacular and microvillar), neuronal (olfactory sensory neurons) and basal (horizontal and globose basal cells). The existence of microvillar cells (MVCs) is well documented but their nature and function remains unclear. An important transcription factor for the differentiation of MVCs is Skn-1a, with loss of function of Skn-1a in mice resulting in a complete loss of Trpm-5 expressing MVCs, while olfactory sensory neuron differentiation is normal. (Source: Neuropeptides)
Source: Neuropeptides - March 1, 2018 Category: Neuroscience Authors: Kharen L. Doyle, Carla Cunha, Yvonne Hort, Ramon Tasan, G ünther Sperk, John Shine, Herbert Herzog Source Type: research
