Puerarin alleviate radicular pain from lumbar disc herniation by inhibiting ERK-dependent spinal microglia activation
In this study, by using a rat model of lumbar disc herniation, which was induced by autologous nucleus pulposus (NP) implantation, the analgesic effect of puerarin on radicular pain was tested. (Source: Neuropeptides)
Source: Neuropeptides - October 10, 2018 Category: Neuroscience Authors: Yi Zhong, Yang-Liang Huang, Yu-Ming Hu, Li-Rong Zhu, Yuan-Shu Zhao Source Type: research
Editorial Board
(Source: Neuropeptides)
Source: Neuropeptides - September 22, 2018 Category: Neuroscience Source Type: research
Oxytocin and excitation/inhibition balance in social recognition
Social recognition is the sensitive domains of complex behavior critical for identification, interpretation and storage of socially meaningful information. Social recognition develops throughout childhood and adolescent, and is affected in a wide variety of psychiatric disorders. Recently, new data appeared on the molecular mechanisms of these processes, particularly, the excitatory –inhibitory (E/I) ratio which is modified during development, and then E/I balance is established in the adult brain. (Source: Neuropeptides)
Source: Neuropeptides - September 21, 2018 Category: Neuroscience Authors: Olga L. Lopatina, Yulia K. Komleva, Yana V. Gorina, Raisa Ya Olovyannikova, Lyudmila V. Trufanova, Takanori Hashimoto, Tetsuya Takahashi, Mitsuru Kikuchi, Yoshio Minabe, Haruhiro Higashida, Alla B. Salmina Tags: News and Reviews Source Type: research
Effects of burns on gut motor and mucosa functions
This review analyzed the published studies on the effects of thermal injury on gastrointestinal motility and mucosal damage. Our strategy was to integrate all available evidence to provide a complete review on the prokinetic properties of variable reagents and the potential clinical treatment of mucosal damage and gastrointestinal dysmotility after thermal injury. We classified the studies into two major groups: studies on gastrointestinal dysmotility and studies on mucosal damage. We also subclassified the studies into 3 parts: stomach, small intestine, and colon. (Source: Neuropeptides)
Source: Neuropeptides - September 21, 2018 Category: Neuroscience Authors: Hsien-Hao Huang, Yu-chi Lee, Chih-Yen Chen Tags: News and reviews Source Type: research
Brain-derived neurotrophic factor and epilepsy: a systematic review
Several in vitro, ex vivo and in vivo studies imply brain-derived neurotrophic factor (BDNF) in the pathophysiology of epilepsy. Aim of our work is to report the most important findings regarding BDNF and its potential role in epilepsy. We targeted those publications addressing both in vitro and in vivo evidences of relationship between BDNF and epilepsy. Basic researches, randomized trials, cohort studies, and reviews were contemplated to give a breadth of clinical data. Medline, CENTRAL, and Science Direct were searched till August 2017 using keywords agreed by the authors. (Source: Neuropeptides)
Source: Neuropeptides - September 20, 2018 Category: Neuroscience Authors: Lorenzo Iughetti, Laura Lucaccioni, Francesco Fuggetto, Barbara Predieri, Alberto Berardi, Fabrizio Ferrari Tags: News and Reviews Source Type: research
Potential roles of neurotensin on cognition in conditions of obese-insulin resistance
Neurotensin is an endogenous tridecapeptide that can be found in both central and peripheral nervous systems. Under normal physiological conditions, neurotensin is involved in the regulation of pain, body temperature, physical activity, appetite as well as learning and memory. In addition, it plays an important role in fat metabolism. Previous studies have demonstrated that alterations of neurotensin levels were associated with several neuropathological conditions such as Alzheimer's disease, mood disorders, and obesity associated eating disorders. (Source: Neuropeptides)
Source: Neuropeptides - September 7, 2018 Category: Neuroscience Authors: Napatsorn Saiyasit, Jirapas Sripetchwandee, Nipon Chattipakorn, Siriporn C. Chattipakorn Tags: News and Reviews Source Type: research
Reduction in voluntary food intake, but not fasting, stimulates hypothalamic gonadotropin-inhibitory hormone precursor mRNA expression in chicks under heat stress
Heat stress is an issue of rising concern across the globe. Recently, we found that mRNA expression of gonadotropin-inhibitory hormone (GnIH), an orexigenic neuropeptide, was increased in the heat-exposed chick brain when food intake was reduced. The aim of the current study was to examine mRNA expression of GnIH and of the glucocorticoid receptors (GRs) in the hypothalamus as well as the plasma corticosterone (CORT) and its metabolites in 14-d-old chicks exposed to a high ambient temperature (HT; 40 ± 1 °C for 1 or 5 h) or a control thermoneutral temperature (CT; 30 ± 1 °C), either with free access to f...
Source: Neuropeptides - September 6, 2018 Category: Neuroscience Authors: Mohammad A. Bahry, Hui Yang, Phuong V. Tran, Phong H. Do, Guofeng Han, Hatem M. Eltahan, Vishwajit S. Chowdhury, Mitsuhiro Furuse Source Type: research
Up-regulation of TNF Receptor-associated Factor 7 after spinal cord injury in rats may have implication for neuronal apoptosis
In this study, we have performed an acute SCI model in adult rats and investigated the dynamic changes of TRAF7 expression in the spinal cord. (Source: Neuropeptides)
Source: Neuropeptides - August 7, 2018 Category: Neuroscience Authors: Dawei Xu, Wei Zhao, Chengniu Wang, Hao Zhu, Mingqing He, Xinhui Zhu, Wei Liu, Fei Wang, Jianbo Fan, Chu Chen, Daoran Cui, Zhiming Cui Source Type: research
Editorial Board
(Source: Neuropeptides)
Source: Neuropeptides - July 21, 2018 Category: Neuroscience Source Type: research
Neuroprotective effects of the novel GLP-1 long acting analogue semaglutide in the MPTP Parkinson's disease mouse model
Parkinson's disease (PD) is the second most common neurodegenerative disease, and there is no recognised therapy to cure it. Recently, it has been shown that treatments to improve insulin resistance in type 2 diabetes (T2DM) may be useful for PD patients. In previous studies, the glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide showed good neuroprotective effects in animal models of PD. In addition, the GLP-1 mimetic exendin-4 has shown good protective effects in PD patients in a phase II clinical trial. (Source: Neuropeptides)
Source: Neuropeptides - July 12, 2018 Category: Neuroscience Authors: Liping Zhang, Lingyu Zhang, Lin Li, Christian H ölscher Source Type: research
Intranasal cerebrolysin improves cognitive function and structural synaptic plasticity in photothrombotic mouse model of medial prefrontal cortex ischemia
Medial prefrontal cortex (mPFC) ischemia affects post-stroke cognitive outcomes. We aimed to investigate the effects of different doses and routes of cerebrolysin (CBL) on the structural synaptic plasticity and cognitive function after mPFC ischemia in mice. Thence, CBL (1, 2.5 ml/kg/i.p./daily) or (1 ml/kg/i.n./daily), were administrated in photothrombotic mouse model of mPFC ischemia for two weeks. Episodic and spatial memories were assessed by the What-Where-Which (WWWhich) and Barnes tasks. Growth-associated protein 43 (GAP-43), postsynaptic density-95 (PSD-95), a nd synaptophysin (SYN) levels were measured in the...
Source: Neuropeptides - July 9, 2018 Category: Neuroscience Authors: Saeed Sadigh-Eteghad, Mohammad Hossein Geranmayeh, Alireza Majdi, Farzad Salehpour, Javad Mahmoudi, Mehdi Farhoudi Source Type: research
Sirtuin 1 and Alzheimer's disease: An up-to-date review
Sirtuins are NAD+-dependent enzymes that regulate a large number of cellular pathways and are related to aging and age-associated diseases. In recent years, the role of sirtuins in Alzheimer's disease (AD) has become increasingly apparent. Growing evidence demonstrates that sirtuin 1 (SIRT1) regulates many processes that go amiss in AD, such as: APP processing, neuroinflammation, neurodegeneration, and mitochondrial dysfunction. Here we review how SIRT1 affects AD and cognition, the main mechanisms in which SIRT1 is related to AD pathology, and its importance for the prevention and possible diagnosis of AD. (Source: Neuropeptides)
Source: Neuropeptides - July 9, 2018 Category: Neuroscience Authors: Liara Rizzi, Matheus Roriz-Cruz Tags: News and reviews Source Type: research
PK2 β ligand, a splice variant of prokineticin 2, is able to modulate and drive signaling through PKR1 receptor
Prokineticin-2 (PK2) is a secreted bioactive peptide that signals through two GPCRs, the prokineticin receptors (PKRs), and regulates a variety of biological processes including angiogenesis, immunity and nociception. The PK2 primary transcript has two alternative splice variants, PK2 and PK2L (a Long form) which is cleaved in an active peptide, named PK2 β that preferentially binds to PKR1 receptor.The aim of this study was to characterize the PK2β.Using different Saccharomyces cerevisiae strains, we examined the specificity of PKR1 and PKR2 G-protein coupling following PK2β binding. (Source: Neuropeptides)
Source: Neuropeptides - July 2, 2018 Category: Neuroscience Authors: Roberta Lattanzi, Daniela Maftei, Lucia Negri, Ilaria Fusco, Rossella Miele Source Type: research
Maternal voluntary exercise ameliorates learning deficit in rat pups exposed, in utero, to valproic acid; role of BDNF and VEGF and their receptors
In this study we evaluated the preventive potential of maternal voluntary exercise on cognitive deficits induced by in utero exposure to VPA, in rat pups. (Source: Neuropeptides)
Source: Neuropeptides - July 2, 2018 Category: Neuroscience Authors: R. Rahimi, M.M. Akhavan, K. Kamyab, S.A. Ebrahimi Source Type: research
The antitumor effect of TAT-DCF1 peptide in glioma cells
Glioblastoma is most malignant brain cancer, thus, establishing an effective therapy is paramount. Our previous results indicate that dendritic cell-derived factor (DCF1) is an attractive candidate for therapy against Glioblastoma, since its overexpression in Glioblastoma U251 cells leads to apoptosis. However, the delivery approach limits its clinical application, in this paper, we expressed TAT-DCF1 fusion protein in E.coli in order to surmount its current delivery problems. (Source: Neuropeptides)
Source: Neuropeptides - June 25, 2018 Category: Neuroscience Authors: Jiao Wang, Qian Wang, Fangfang Zhou, Jie Li, Qian Li, Hong Zhou, Shiman Li, Sujuan Ma, Tieqiao Wen Source Type: research
