Editorial Board
(Source: Neuropeptides)
Source: Neuropeptides - October 1, 2017 Category: Neuroscience Source Type: research
Ghrelin projection from the lateral hypothalamus area to the dorsal vagal complex and its regulation of gastric motility in cisplatin-treated rats
To investigate ghrelin projection from the lateral hypothalamus area (LHA) to the dorsal vagal complex (DVC) and its regulation of gastric motility in cisplatin-treated rats. (Source: Neuropeptides)
Source: Neuropeptides - September 27, 2017 Category: Neuroscience Authors: Yanling Gong, Yang Liu, Yaoyao Guo, Manqing Su, Yifan Zhong, Luo Xu, Feifei Guo, Shengli Gao Source Type: research
The hemoglobin derived peptide LVV-hemorphin-7 evokes behavioral effects mediated by oxytocin receptors
LVV-hemorphin-7 (LVV-h7) is bioactive peptide resulting from degradation of hemoglobin β-globin chain. LVV-h7 is a specific agonist of angiotensin IV receptor. This receptor belongs to the class of insulin-regulated aminopeptidases (IRAP), which displays oxytocinase activity. Herein, our aims were to assess whether: i) LVV-h7 modifies centrally organized behavior and cardiovascular r esponses to stress and ii) mechanisms underlying LVV-h7 effects involve activation of oxytocin (OT) receptors, probably as result of reduction of IRAP proteolytic activity upon OT. (Source: Neuropeptides)
Source: Neuropeptides - September 27, 2017 Category: Neuroscience Authors: Kellen Rosa da Cruz, Larissa C órdova Turones, Gabriel Camargo-Silva, Karina Pereira Gomes, Michelle Mendanha Mendonça, Pablinny Galdino, Christielly Rodrigues-Silva, Robson Augusto Souza dos Santos, Elson Alves Costa, Paulo Cesar Ghedini, Danielle Ianz Source Type: research
Role of orexin receptors in the ventral tegmental area on acquisition and expression of morphine-induced conditioned place preference in the rats
The orexins are hypothalamic neuropeptides and their role in reward processing and drug addiction has been demonstrated. The extent of involvement of each orexin receptor in the acquisition and expression of conditioned place preference (CPP) for morphine is still a matter of controversy. We investigated the functional differences between orexin-1 and -2 receptor blockade in the ventral tegmental area (VTA) on the acquisition and expression of morphine CPP. A total of 86 adult male Wistar rats weighing 250 ±30g (age 7–8weeks) received intra-VTA microinjection of either SB334867 (0.1, 1 and 10nM), a selective orexin-1 re...
Source: Neuropeptides - September 4, 2017 Category: Neuroscience Authors: Sharareh Farahimanesh, Shahram Zarrabian, Abbas Haghparast Source Type: research
Spatiotemporal expression of FOXA1 correlates with reactive gliosis after spinal cord injury
Forkhead box A1 (FOXA1) is a member of the FOX family of transcription factors and involved in various mammalian processes. However, the expression and function of FOXA1 in central nervous system (CNS) are still with limited acquaintance. In present study, we performed an acute spinal cord injury (SCI) model in adult rats and investigated the dynamic changes of FOXA1 expression in spinal cord. We found that FOXA1 protein levels were significantly increased after SCI and we observed that the expression of FOXA1 is enhanced in the white matter. (Source: Neuropeptides)
Source: Neuropeptides - August 18, 2017 Category: Neuroscience Authors: Dongliang Wang, Siqing Wang, Biao Ji, Minqian Zheng Source Type: research
Role of hindbrain adenosine 5 ′-monophosphate-activated protein kinase (AMPK) in hypothalamic AMPK and metabolic neuropeptide adaptation to recurring insulin-induced hypoglycemia in the male rat
Glucose counter-regulatory dysfunction correlates with impaired activation of the hypothalamic metabolic sensor adenosine 5 ′-monophosphate-activated protein kinase (AMPK). Hypothalamic AMPK is controlled by hindbrain energy status; we examined here whether hindbrain AMPK regulates hypothalamic AMPK and metabolic neurotransmitter maladaptation to recurring insulin-induced hypoglycemia (RIIH). Brain tissue was harvested after single versus serial insulin dosing for Western blot analysis of AMPK, phospho-AMPK (pAMPK), and relevant biosynthetic enzyme/neuropeptide expression in micro-punch dissected arcuate (ARH), ventromed...
Source: Neuropeptides - August 9, 2017 Category: Neuroscience Authors: Santosh K. Mandal, Prem K. Shrestha, Fahaad S.H. Alenazi, Manita Shakya, Hussain Alhamami, Karen P. Briski Source Type: research
LEPR polymorphism may affect energy balance during weight loss among Brazilians obese adolescents
Leptin is an adipokine released mainly by adipose tissue, with many functions including regulation of energy balance. However, little is known about the effect of LEPR polymorphism on orexigenic and anorexigenic neuropeptides. Thus, the aim of the present study is to verify the influence of LEPR polymorphism (rs2767485) on serum orexigenic (NPY, MCH and AgRP) and anorexigenic (Leptin and α-MSH) neuropeptides levels among obese adolescents submitted to 1year of multicomponent weight loss therapy. (Source: Neuropeptides)
Source: Neuropeptides - August 1, 2017 Category: Neuroscience Authors: Fl ávia Campos Corgosinho, Sandro Soares Almeida, Lian Tock, João Bosco Pesquero, Ronaldo Carvalho Araújo, Ana Paula Grotti Clemente, Bárbara Dal'Molin Netto, Raquel Munhoz da Silveira Campos, Deborah Cristina Landi Masquio, Joana Pereira de Carvalho Source Type: research
Gonadotropin inhibitory hormone and RF9 stimulate hypothalamic-pituitary-adrenal axis in adult male rhesus monkeys
Stress activates gonadotropin inhibitory hormone (GnIH), hypothalamic-pituitary-adrenal axis (HPA-axis) and represses hypothalamic-pituitary-gonadal axis (HPG-axis) but RF9 administration relieves stress-induced repression of the HPG-axis. Importantly, it was not known whether GnIH signaling and RF9 synthetic peptide modulate the HPA axis. To assess this, mammalian orthologs of GnIH (RFRP-1 and RFRP-3) and RF9 were administered to intact adult male rhesus monkeys. RFRP-1 (125 μg/animal), RFRP-3 (250μg/animal) and RF9 (0.1mg/kg BW) were intravenously (iv) injected into normal fed (n=4) monkeys. (Source: Neuropeptides)
Source: Neuropeptides - July 25, 2017 Category: Neuroscience Authors: Rahim Ullah, Aalia Batool, Madiha Wazir, Rabia Naz, Tanzil Ur Rahman, Fazal Wahab, Muhammad Shahab, Junfen Fu Source Type: research
Involvement of GABAA receptors in the regulation of social preference and emotional behaviors by oxytocin in the central amygdala of female mandarin voles
In this study we evaluated the effects of intra-CeA OT administration of different doses (0.1, 1 and 10ng/side), OT receptor antagonist (OTR-A) (1, 10 and 100ng/side) and OT plus OTR-A on social and emotional behavior using a social preference paradigm, open field test and elevated plus maze test in female monogamous mandarin voles (Microtus mandarinus). (Source: Neuropeptides)
Source: Neuropeptides - July 25, 2017 Category: Neuroscience Authors: Na Dong, Peirong Du, Xin Hao, Zhixiong He, Wenjuan Hou, Limin Wang, Wei Yuan, Jinfeng Yang, Rui Jia, Fadao Tai Source Type: research
Potential role of CXCL10/CXCR3 signaling in the development of morphine tolerance in periaqueductal gray
This study aims to investigate whether CXCL10/CXCR3 signaling in periaqueductal gray (PAG) contributes to the development of morphine tolerance by modulating neuron-microglia interaction. The results showed that the expressions of CXCR3 and CXCL10 were gradually increased in parallel with repeated morphine administration and activation of microglia. (Source: Neuropeptides)
Source: Neuropeptides - July 24, 2017 Category: Neuroscience Authors: Wei Wang, Yawen Peng, Hui Yang, Huilian Bu, Genhua Guo, Daiqiang Liu, Bin Shu, Xuebi Tian, Ailin Luo, Xuming Zhang, Feng Gao Source Type: research
Editorial Board
(Source: Neuropeptides)
Source: Neuropeptides - July 18, 2017 Category: Neuroscience Source Type: research
Combine effect of Chondroitinase ABC and low level laser (660nm) on spinal cord injury model in adult male rats
This study performed on 44 male Wistar rats, spinal cord injury induced by a clip compression injury. Animals received two-weeks treatment of 660nm low level laser (LLL) and intraspinal injection of 1 μg ChABC. (Source: Neuropeptides)
Source: Neuropeptides - July 14, 2017 Category: Neuroscience Authors: Atousa Janzadeh, Arash Sarveazad, Mahmoud Yousefifard, Sima Dameni, Fazel Sahraneshin Samani, Kobra Mokhtarian, Farinaz Nasirinezhad Source Type: research
Differently polarized macrophages affect the viability and growth of NSPCs by regulating the expression of PACAP
ObjectiveTo explore the influence of differently polarized macrophages, M1 or M2, to viability and growth of NSPCs and its possible mechanism, especially the role of pituitary adenylate cyclase-activating polypeptide (PACAP) in it. (Source: Neuropeptides)
Source: Neuropeptides - July 11, 2017 Category: Neuroscience Authors: Min Liu, Ming Deng, Yonggang Ma Source Type: research
Prenatal exposure to brain-specific anion transporter-1-specific monoclonal antibodies impairs cognitive function in post-natal life
In this study, we tested whether exposure in utero with BSAT-1-specific monoclonal antibodies (MabBSAT) will affect the cognitive function of the progeny. On gestation day 16th, females were intravenously treated with MabBSAT, non-specific antibodies (control 1), and saline (control 2). (Source: Neuropeptides)
Source: Neuropeptides - July 4, 2017 Category: Neuroscience Authors: Eugene A. Zubkov, Yana A. Zorkina, Olga I. Gurina, Pavel A. Melnikov, Anna Y. Morozova, Vladimir P. Chekhonin Source Type: research
Effects of pituitary adenylate cyclase activating polypeptide on small intestinal INT 407 cells
Pituitary adenylate cyclase activating polypeptide (PACAP) is an endogenous neuropeptide having a widespread distribution both in the nervous system and peripheral organs including the gastrointestinal tract. It has been shown to exert actions on intestinal functions, mainly affecting glandular secretion and motility. PACAP has several different effects on cell survival depending on the cell type and the applied stimulus. Its influences on small intestinal epithelial cells are not yet elucidated, therefore the aim of the present study was to investigate the effects of PACAP on intestinal epithelial cells having high turnov...
Source: Neuropeptides - July 4, 2017 Category: Neuroscience Authors: A. Illes, B. Opper, D. Reglodi, M. Kerenyi, P. Czetany, A. Boronkai, E. Schafer, G. Toth, E. Fabian, G. Horvath Source Type: research
