Potential role of CXCL10/CXCR3 signaling in the development of morphine tolerance in periaqueductal gray

This study aims to investigate whether CXCL10/CXCR3 signaling in periaqueductal gray (PAG) contributes to the development of morphine tolerance by modulating neuron-microglia interaction. The results showed that the expressions of CXCR3 and CXCL10 were gradually increased in parallel with repeated morphine administration and activation of microglia.

Source: Neuropeptides - July 24, 2017 Category: Neuroscience Authors: Wei Wang, Yawen Peng, Hui Yang, Huilian Bu, Genhua Guo, Daiqiang Liu, Bin Shu, Xuebi Tian, Ailin Luo, Xuming Zhang, Feng Gao Source Type: research