Association study of two functional single nucleotide polymorphisms of neuropeptide y gene with multiple sclerosis

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system characterized by brain inflammation, demyelination and axonal loss. Neuropeptide Y (NPY) has a critical role in the maintenance of homeostasis in the immune system and coping of stress condition. In current study we analyzed 188 patients suffering from MS and 204 unrelated healthy controls for two functional single nucleotide polymorphisms (SNPs), NPY _20T>C (rs16139) and NPY _-485T>C (rs16147) using PCR-RFLP and Mismatch PCR-RFLP methods.

Source: Neuropeptides - August 7, 2016 Category: Neuroscience Authors: Seyed Mahdi Mohammadi, Zeinab Shirvani Farsani, Rozita Dosti, Mohammad Ali Sahraian, Mehrdad Behmanesh Source Type: research