Apelin-13 protects neurovascular unit against ischemic injuries through the effects of vascular endothelial growth factor

Apelin-13 has protective effects on many neurological diseases, including cerebral ischemia. Here, we aimed to test Apelin-13's effects on ischemic neurovascular unit (NVU) injuries and investigate whether the effects were dependent on vascular endothelial growth factor (VEGF). We detected the expression of VEGF and its receptors (VEGFRs) induced by Apelin-13 injection at 1d, 3d, 7d and 14d after middle cerebral artery occlusion (MCAO). Meanwhile, we examined the effects of Apelin-13 on NVU in both in vivo and in vitro experiments as well as whether the effects were VEGF dependent by using VEGF antibody.

Source: Neuropeptides - August 15, 2016 Category: Neuroscience Authors: Chuyi Huang, Chuanfu Dai, Kai Gong, Huancong Zuo, Heling Chu Source Type: research