The Effect Of Leptin, Ghrelin, And Neuropeptide-Y On Serum Tnf- Α, Il-1β, Il-6, Fgf-2, Galanin Levels and Oxidative Stress In An Experimental Generalized Convulsive Seizure Model

The objective of this study is to examine the effects of the endogenous ligands leptin, ghrelin, and neuropeptide Y (NPY) on seizure generation, the oxidant/antioxidant balance, and cytokine levels, which are a result of immune response in a convulsive seizure model. With this goal, Wistar rats were divided into 5 groups —Group 1: Saline, Group 2: Saline + PTZ (65mg/kg), Group 3: leptin (4mg/kg)+PTZ, Group 4: ghrelin (80μg/kg)+PTZ, and Group 5: NPY (60μg/kg)+PTZ. All injections were delivered intraperitoneally, and simultaneous electroencephalography (EEG) records were obtained.
Source: Neuropeptides - Category: Neuroscience Authors: Source Type: research