Contents: Mol.Nutr.Food Res. 8'14
(Source: Molecular Nutrition)
Source: Molecular Nutrition - August 4, 2014 Category: Nutrition Tags: Contents Source Type: research
Editorial Board: Mol.Nutr.Food Res. 8'14
(Source: Molecular Nutrition)
Source: Molecular Nutrition - August 4, 2014 Category: Nutrition Tags: Editorial Board Source Type: research
Cover Picture: Mol.Nutr.Food Res. 8'14
(Source: Molecular Nutrition)
Source: Molecular Nutrition - August 4, 2014 Category: Nutrition Tags: Cover Picture Source Type: research
Phenylpropenoic acid glucoside augments pancreatic beta cell mass in high‐fat diet‐fed mice and protects beta cells from ER stress‐induced apoptosis
ConclusionsWe identified an antidiabetic phytochemical that protects pancreatic beta cells from ER stress and apoptosis induced by high‐fat diet/lipotoxicity. At the tissue level, this led to a tripling of beta cell mass. At the molecular level, the protective effect of the phytochemical was mediated by increasing BCL2 expression in beta cells. (Source: Molecular Nutrition)
Source: Molecular Nutrition - August 4, 2014 Category: Nutrition Authors: Iris Mathijs, Daniel A. Da Cunha, Eddy Himpe, Laurence Ladriere, Nireshni Chellan, Candice R. Roux, Elizabeth Joubert, Christo Muller, Miriam Cnop, Johan Louw, Luc Bouwens Tags: Research Article Source Type: research
Postprandial cell defense system responses to meal formulations: Stratification through gene expression profiling
ConclusionThis study demonstrates postprandial immune, inflammatory, redox, metabolic, and DNA repair responses that are largely independent of fat type consumed (unsaturated/saturated) or addition of beetroot extract, in apparently healthy individuals. However, postprandial responses can be characterized by regulation of gene expression associated with markers linked to health status and are subject to interindividual variation that can influence postprandial responses. (Source: Molecular Nutrition)
Source: Molecular Nutrition - August 4, 2014 Category: Nutrition Authors: Janice E. Drew, Andrew J. Farquharson, Graham W. Horgan, Susan J. Duthie, Garry G. Duthie Tags: Research Article Source Type: research
Betanin – a food colorant with biological activity
This article is protected by copyright. All rights reserved (Source: Molecular Nutrition)
Source: Molecular Nutrition - August 1, 2014 Category: Nutrition Authors: Tuba Esatbeyoglu, Anika Wagner, Valérie B. Schini‐Kerth, Gerald Rimbach Tags: Review Source Type: research
Consumption of selenium‐enriched broccoli increases cytokine production in human peripheral blood mononuclear cells stimulated ex vivo, a preliminary human intervention study
ConclusionsThis study indicates that consumption of Se‐enriched broccoli may increase immune responses towards a range of immune challenges.This article is protected by copyright. All rights reserved (Source: Molecular Nutrition)
Source: Molecular Nutrition - August 1, 2014 Category: Nutrition Authors: Kerry L. Bentley‐Hewitt, Ronan Chen, Ross Lill, Duncan Hedderley, Thanuja D. Herath, Adam Matich, Marian McKenzie Tags: Research Article Source Type: research
Consortium analysis of gene and gene–folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk
ConclusionVariation in pyrimidine metabolism genes, particularly DPYD, which was previously reported to be associated with OC, may influence risk; however, stratification by folate intake is unlikely to modify disease risk appreciably in these women. SHMT1 SNP‐by‐folate interactions are plausible but require further validation. Polymorphisms in selected genes in purine metabolism were not associated with OC. (Source: Molecular Nutrition)
Source: Molecular Nutrition - July 28, 2014 Category: Nutrition Authors: Linda E. Kelemen, Kathryn L. Terry, Marc T. Goodman, Penelope M. Webb, Elisa V. Bandera, Valerie McGuire, Mary Anne Rossing, Qinggang Wang, Ed Dicks, Jonathan P. Tyrer, Honglin Song, Jolanta Kupryjanczyk, Agnieszka Dansonka‐Mieszkowska, Joanna Plisiecka Tags: Research Article Source Type: research
Amyloid‐beta (Aβ1–42)‐induced paralysis in Caenorhabditis elegans is inhibited by the polyphenol quercetin through activation of protein degradation pathways
ConclusionThe proteostasis network, including unfolded protein response, defines the aggregation of Aβ1–42 and the associated paralysis phenotype in a nematode model for Alzheimer's disease. The polyphenol quercetin, by specifically activating macroautophagy and proteasomal degradation pathways, proved able to prevent Aβ1–42 agregation and paralysis. (Source: Molecular Nutrition)
Source: Molecular Nutrition - July 28, 2014 Category: Nutrition Authors: Charlotte Regitz, Lisa Marie Dußling, Uwe Wenzel Tags: Research Article Source Type: research
Punicalagin inhibits neuroinflammation in LPS‐activated rat primary microglia
ConclusionThese results suggest that punicalagin inhibits neuroinflammation in LPS‐activated microglia through interference with NF‐κB signalling, suggesting its potential as a nutritional preventive strategy in neurodegenerative disorders. (Source: Molecular Nutrition)
Source: Molecular Nutrition - July 28, 2014 Category: Nutrition Authors: Olumayokun A. Olajide, Asit Kumar, Ravikanth Velagapudi, Uchechukwu P. Okorji, Bernd L. Fiebich Tags: Research Article Source Type: research
Resveratrol inhibits glucose‐induced migration of vascular smooth muscle cells mediated by focal adhesion kinase
ConclusionThe antimigratory effects of resveratrol by reduced MMP expression through the inhibition of Rac1, p‐FAK, and lamellipodia formation and the activation of p‐AKT and p‐ERK1/2 suggest that resveratrol is a potential compound for the treatment of vascular diseases via the regulation of VSMC migration. (Source: Molecular Nutrition)
Source: Molecular Nutrition - March 1, 2014 Category: Nutrition Authors: Yi‐Chiao Lin, Li‐Hsuen Chen, T. Varadharajan, May‐Jywan Tsai, Yi‐Chen Chia, Ta‐Chun Yuan, Ping‐Jyun Sung, Ching‐Feng Weng Tags: Research Article Source Type: research
Dietary deprivation of each essential amino acid induces differential systemic adaptive responses in mice
ConclusionDietary deprivation of individual EAAs induced systemic adaptive responses that differed in magnitude and molecular machinery. (Source: Molecular Nutrition)
Source: Molecular Nutrition - February 24, 2014 Category: Nutrition Authors: Shotaro Kamata, Junya Yamamoto, Kenta Kamijo, Takahito Ochiai, Tamako Morita, Yurika Yoshitomi, Yoshifumi Hagiya, Masashi Kubota, Rika Ohkubo, Maiko Kawaguchi, Toshiyuki Himi, Tadashi Kasahara, Isao Ishii Tags: Research Article Source Type: research
Hibiscus sabdariffa extract lowers blood pressure and improves endothelial function
Polyphenols from Hibiscus sabdariffa calices were administered to patients with metabolic syndrome (125 mg/kg/day for 4 wk, n = 31) and spontaneously hypertensive rats (125 or 60 mg/kg in a single dose or daily for 1 wk, n = 8 for each experimental group). The H. sabdariffa extract improved metabolism, displayed potent anti‐inflammatory and antioxidant activities, and significantly reduced blood pressure in both humans and rats. Diuresis and inhibition of the angiotensin I‐converting enzyme were found to be less important mechanisms than those related to the antioxidant, anti‐inflammatory, and endothelium‐dependent...
Source: Molecular Nutrition - February 24, 2014 Category: Nutrition Authors: Jorge Joven, Isabel March, Eugenia Espinel, Salvador Fernández‐Arroyo, Esther Rodríguez‐Gallego, Gerard Aragonès, Raúl Beltrán‐Debón, Carlos Alonso‐Villaverde, Lidia Rios, Vicente Martin‐Paredero, Javier A. Menendez, Vicente Micol, Antonio Tags: Food & Function Source Type: research
Low‐dose diet supplement of a natural flavonoid, luteolin, ameliorates diet‐induced obesity and insulin resistance in mice
ConclusionsAs a natural flavonoid, low‐dose diet supplement of LU ameliorates diet‐induced obesity and insulin resistance in mice, suggesting a new therapeutic and interventional approach for these diseases. (Source: Molecular Nutrition)
Source: Molecular Nutrition - February 24, 2014 Category: Nutrition Authors: Na Xu, Lei Zhang, Jing Dong, Xian Zhang, Yan‐Guang Chen, Bin Bao, Jian Liu Tags: Research Article Source Type: research
Postprandial triglyceride‐rich lipoproteins promote invasion of human coronary artery smooth muscle cells in a fatty‐acid manner through PI3k‐Rac1‐JNK signaling
ConclusionWe demonstrate for the first time that TRLs induce hCASMCs invasion in a fatty acid dependent manner. This effect in TRLs–SFAs is mediated by the PI3k‐Rac1‐JNK, RhoA, and Rac1‐MMP2 pathways. The ingestion of MUFA, compared to other dietary fatty acids such as SFA, could be considered as a nutritional strategy to reduce the atherosclerotic plaque formation. (Source: Molecular Nutrition)
Source: Molecular Nutrition - February 24, 2014 Category: Nutrition Authors: Lourdes M. Varela, Beatriz Bermúdez, Almudena Ortega‐Gómez, Sergio López, Rosario Sánchez, Jose Villar, Christelle Anguille, Francisco J. G. Muriana, Pierre Roux, Rocío Abia Tags: Research Article Source Type: research
