Consortium analysis of gene and gene–folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk

ConclusionVariation in pyrimidine metabolism genes, particularly DPYD, which was previously reported to be associated with OC, may influence risk; however, stratification by folate intake is unlikely to modify disease risk appreciably in these women. SHMT1 SNP‐by‐folate interactions are plausible but require further validation. Polymorphisms in selected genes in purine metabolism were not associated with OC.

Source: Molecular Nutrition - July 28, 2014 Category: Nutrition Authors: Linda E. Kelemen, Kathryn L. Terry, Marc T. Goodman, Penelope M. Webb, Elisa V. Bandera, Valerie McGuire, Mary Anne Rossing, Qinggang Wang, Ed Dicks, Jonathan P. Tyrer, Honglin Song, Jolanta Kupryjanczyk, Agnieszka Dansonka‐Mieszkowska, Joanna Plisiecka Tags: Research Article Source Type: research