Amyloid‐beta (Aβ1–42)‐induced paralysis in Caenorhabditis elegans is inhibited by the polyphenol quercetin through activation of protein degradation pathways

ConclusionThe proteostasis network, including unfolded protein response, defines the aggregation of Aβ1–42 and the associated paralysis phenotype in a nematode model for Alzheimer's disease. The polyphenol quercetin, by specifically activating macroautophagy and proteasomal degradation pathways, proved able to prevent Aβ1–42 agregation and paralysis.

Source: Molecular Nutrition - July 28, 2014 Category: Nutrition Authors: Charlotte Regitz, Lisa Marie Dußling, Uwe Wenzel Tags: Research Article Source Type: research