In This Issue
(Source: International Immunology)
Source: International Immunology - July 28, 2014 Category: Allergy & Immunology Tags: In This Issue Source Type: research
Table of Contents
(Source: International Immunology)
Source: International Immunology - July 28, 2014 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Subscriptions
(Source: International Immunology)
Source: International Immunology - July 28, 2014 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Cover
(Source: International Immunology)
Source: International Immunology - July 28, 2014 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
PD-1 deletion restores susceptibility to experimental autoimmune encephalomyelitis in miR-155-deficient mice
MiR-155 –/– mice are highly resistant to experimental autoimmune encephalomyelitis (EAE), while Pdcd1 –/– mice develop a more severe form of the disease. To determine the conflicting roles of these two molecules in the disease, we generated miR-155 –/– Pdcd1 –/– double knockout (DKO) mice. We found that ablation of programmed cell death protein 1 (PD-1) expression in miR-155-deficient mice restored the susceptibility to EAE. The increased severity of the disease in DKO mice was accompanied by an enhanced T-cell infiltration into the brain as well as an in...
Source: International Immunology - June 30, 2014 Category: Allergy & Immunology Authors: Zhang, J., Braun, M. Y. Tags: Original Research Source Type: research
Activation-induced cytidine deaminase is dispensable for virus-mediated liver and skin tumor development in mouse models
In conclusion, AID does not appear to be required for tumor development in the two virus-induced tumor mouse models tested although AID expressed in infiltrating B cells may promote inflammatory reactions in HCV core protein-induced liver pathogenesis. (Source: International Immunology)
Source: International Immunology - June 30, 2014 Category: Allergy & Immunology Authors: Nguyen, T., Xu, J., Chikuma, S., Hiai, H., Kinoshita, K., Moriya, K., Koike, K., Marcuzzi, G. P., Pfister, H., Honjo, T., Kobayashi, M. Tags: Original Research Source Type: research
B-CLL cells acquire APC- and CTL-like phenotypic characteristics after stimulation with CpG ODN and IL-21
In conclusion, CpG/IL-21-stimulated B-CLL cells acquire features that are reminiscent of killer dendritic cells, and which result in enhanced immunogenicity, cytotoxicity and apoptosis. Our results provide novel insights into the aberrant immune state of B-CLL cells and may establish a basis for the development of an innovative cellular vaccination approach in B-CLL. (Source: International Immunology)
Source: International Immunology - June 30, 2014 Category: Allergy & Immunology Authors: Hagn, M., Blackwell, S. E., Beyer, T., Ebel, V., Fabricius, D., Lindner, S., Stilgenbauer, S., Simmet, T., Tam, C., Neeson, P., Trapani, J. A., Schrezenmeier, H., Weiner, G. J., Jahrsdorfer, B. Tags: Original Research Source Type: research
The TIM-3 pathway ameliorates Theiler's murine encephalomyelitis virus-induced demyelinating disease
In this study, we examined the regulatory role of the TIM-3 pathway in the development of TMEV-induced demyelinating disease (TMEV-IDD). The expression of TIM-3 was increased at both protein and mRNA levels in the spinal cords of mice with TMEV-IDD compared with naive controls. In addition, by utilizing a blocking mAb, we demonstrate that TIM-3 negatively regulates TMEV-specific ex vivo production of IFN- and IL-10 by CD4+ T cells and IFN- by CD8+ T cells from the CNS of mice with TMEV-IDD at 36 days post-infection (dpi). In vivo blockade of TIM-3 by using the anti-TIM-3 mAb resulted in significant exacerbation of the deve...
Source: International Immunology - June 30, 2014 Category: Allergy & Immunology Authors: Kaneyama, T., Tomiki, H., Tsugane, S., Inaba, Y., Ichikawa, M., Akiba, H., Yagita, H., Kim, B. S., Koh, C.-S. Tags: Original Research Source Type: research
IDO2 is critical for IDO1-mediated T-cell regulation and exerts a non-redundant function in inflammation
IDO2 is implicated in tryptophan catabolism and immunity but its physiological functions are not well established. Here we report the characterization of mice genetically deficient in IDO2, which develop normally but exhibit defects in IDO-mediated T-cell regulation and inflammatory responses. Construction of this strain was prompted in part by our discovery that IDO2 function is attenuated in macrophages from Ido1 –/– mice due to altered message splicing, generating a functional mosaic with implications for interpreting findings in Ido1 –/– mice. No apparent defects were observed in Ido2 ...
Source: International Immunology - June 30, 2014 Category: Allergy & Immunology Authors: Metz, R., Smith, C., DuHadaway, J. B., Chandler, P., Baban, B., Merlo, L. M. F., Pigott, E., Keough, M. P., Rust, S., Mellor, A. L., Mandik-Nayak, L., Muller, A. J., Prendergast, G. C. Tags: featured content Source Type: research
Outstanding Merit Award for 2013
(Source: International Immunology)
Source: International Immunology - June 30, 2014 Category: Allergy & Immunology Tags: Award Source Type: research
In This Issue
(Source: International Immunology)
Source: International Immunology - June 30, 2014 Category: Allergy & Immunology Tags: In This Issue Source Type: research
Table of Contents
(Source: International Immunology)
Source: International Immunology - June 30, 2014 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Subscriptions
(Source: International Immunology)
Source: International Immunology - June 30, 2014 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Cover
(Source: International Immunology)
Source: International Immunology - June 30, 2014 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
The open conformation of WASP regulates its nuclear localization and gene transcription in myeloid cells
In this study, we showed that all reported constitutively activating mutants (L270P, S272P and I294T) of WASP were hyperphosphorylated by Src family tyrosine kinases and demonstrated higher actin polymerization activities compared with wild-type (WT) WASP. Further analysis showed a tendency of activating WASP mutants to localize in the nucleus compared with WT or the Y291F mutant of WASP. In addition, we found that WASP could form a complex with nuclear RNA-binding protein, 54kDa (p54nrb) and RNA polymerase II (RNAP II). ChIP assays revealed that WASP associated with DNA, although the affinity was relatively weaker than RN...
Source: International Immunology - May 21, 2014 Category: Allergy & Immunology Authors: Looi, C. Y., Sasahara, Y., Watanabe, Y., Satoh, M., Hakozaki, I., Uchiyama, M., Wong, W. F., Du, W., Uchiyama, T., Kumaki, S., Tsuchiya, S., Kure, S. Tags: Original Research Source Type: research
