Table of Contents
(Source: International Immunology)
Source: International Immunology - February 23, 2016 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Subscriptions
(Source: International Immunology)
Source: International Immunology - February 23, 2016 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Cover
(Source: International Immunology)
Source: International Immunology - February 23, 2016 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Authors reply to 'Granulocytic myeloid-derived suppressor cells in peripheral blood of patients with cutaneous melanoma
(Source: International Immunology)
Source: International Immunology - January 27, 2016 Category: Allergy & Immunology Authors: Stanojevic, I., Djukic, M., Vojvodic, D. Tags: Reply Source Type: research
Granulocytic myeloid-derived suppressor cells in peripheral blood of patients with cutaneous melanoma
(Source: International Immunology)
Source: International Immunology - January 27, 2016 Category: Allergy & Immunology Authors: Franklin, C., Schilling, B. Tags: Letter Source Type: research
A subpopulation that may correspond to granulocytic myeloid-derived suppressor cells reflects the clinical stage and progression of cutaneous melanoma
Seventy-eight melanoma patients and 10 healthy individuals were examined. Follow-up examinations of all melanoma patients were performed regularly every three months. Myeloid-derived suppressor cells (MDSC) were defined as lineage negative (CD3–, CD19–, CD56–), HLA-DR–/low, CD11b+ and CD33+. Classification of granulocytic (GrMDSC) and monocytic (MoMDSC) subsets was based on the CD15 and CD14 expression, respectively. Unlike the MoMDSC, that were present in 60% of healthy controls and 15% of melanoma patients, the GrMDSC were present in all examined participants, and the melanoma patients were found ...
Source: International Immunology - January 27, 2016 Category: Allergy & Immunology Authors: Stanojevic, I., Miller, K., Kandolf-Sekulovic, L., Mijuskovic, Z., Zolotarevski, L., Jovic, M., Gacevic, M., Djukic, M., Arsenijevic, N., Vojvodic, D. Tags: Original Research Source Type: research
IL-28B down-regulates regulatory T cells but does not improve the protective immunity following tuberculosis subunit vaccine immunization
In conclusion, IL-28B down-regulates Tregs following EAMMH vaccination but does not improve the protective immune responses. (Source: International Immunology)
Source: International Immunology - January 27, 2016 Category: Allergy & Immunology Authors: Luo, Y., Ma, X., Liu, X., Lu, X., Niu, H., Yu, H., Bai, C., Peng, J., Xian, Q., Wang, Y., Zhu, B. Tags: Original Research Source Type: research
Murine allergic rhinitis and nasal Th2 activation are mediated via TSLP- and IL-33-signaling pathways
In this study, we examined the roles of TSLP and IL-33 in AR by analyzing acute and chronic AR models. Acute AR mice were intraperitoneally immunized with ragweed, then intranasally challenged with ragweed pollen for four consecutive days. Chronic AR mice were nasally administrated ragweed pollen on consecutive days for 3 weeks. In both models, TSLP receptor (TSLPR)-deficient mice showed defective sneezing responses and reduced serum ragweed-specific IgE levels compared with wild-type (WT) mice. Analyses of bone-marrow chimeric mice demonstrated that hematopoietic cells were responsible for defective sneezing in TSLPR-defi...
Source: International Immunology - January 27, 2016 Category: Allergy & Immunology Authors: Akasaki, S., Matsushita, K., Kato, Y., Fukuoka, A., Iwasaki, N., Nakahira, M., Fujieda, S., Yasuda, K., Yoshimoto, T. Tags: Original Research Source Type: research
High frequency of central memory regulatory T cells allows detection of liver recipients at risk of early acute rejection within the first month after transplantation
Several studies have analyzed the potential of T regulatory cells (Treg cells) as biomarkers of acute rejection (AR). The aim of the present multicenter study was to correlate the percentage of peripheral Treg cells in liver graft recipients drawn at baseline up to 12 months after transplantation with the presence of AR. The percentage of central memory (cm) Treg cells (CD4+CD25highCD45RO+CD62L+) was monitored at pre-transplant and at 1 and 2 weeks, and 1, 2, 3 and 6 months and 1 year post-transplantation. The same validation standard operating procedures were used in all participating centers. Fifteen patients developed A...
Source: International Immunology - January 27, 2016 Category: Allergy & Immunology Authors: Boix-Giner, F., Millan, O., San Segundo, D., Munoz-Cacho, P., Mancebo, E., Llorente, S., Rafael-Valdivia, L., Rimola, A., Fabrega, E., Mrowiec, A., Allende, L., Minguela, A., Bolarin, J. M., Paz-Artal, E., Lopez-Hoyos, M., Brunet, M., Muro, M. Tags: featured content Source Type: research
In This Issue
(Source: International Immunology)
Source: International Immunology - January 27, 2016 Category: Allergy & Immunology Tags: In This Issue Source Type: research
Table of Contents
(Source: International Immunology)
Source: International Immunology - January 27, 2016 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Subscriptions
(Source: International Immunology)
Source: International Immunology - January 27, 2016 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Cover
(Source: International Immunology)
Source: International Immunology - January 27, 2016 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Group 3 innate lymphoid cells: regulating host-commensal bacteria interactions in inflammation and cancer
A delicate balance exists between the mammalian immune system and normally beneficial commensal bacteria that colonize the gastrointestinal tract, which is necessary to maintain tissue homeostasis. Dysregulation of these interactions between the host and commensal bacteria is causally associated with chronic inflammation and the development of cancer. In contrast, recent reports have highlighted that commensal bacteria also play an essential role in promoting anti-tumor immune responses in several contexts, highlighting a paradox whereby interactions between the host and commensal bacteria can influence both pro- and anti-...
Source: International Immunology - December 28, 2015 Category: Allergy & Immunology Authors: Goc, J., Hepworth, M. R., Sonnenberg, G. F. Tags: Invited review Source Type: research
Differentiation and function of group 3 innate lymphoid cells, from embryo to adult
Group 3 innate lymphoid cells (ILC3) represent a heterogeneous population of cells that share the nuclear hormone receptor RORt (retinoic acid receptor-related orphan receptor t) as a master regulator for differentiation and function. ILC3 can be divided into two major subsets based on the cell surface expression of the natural cytotoxicity receptor (NCR), NKp46. A subset of NCR– ILC3 includes the previously known lymphoid-tissue inducer cells that are essential for the embryonic formation of peripheral lymph nodes and Peyer’s patches. After birth, the NCR– and NCR+ ILC3 contribute to the maintenance of h...
Source: International Immunology - December 28, 2015 Category: Allergy & Immunology Authors: van de Pavert, S. A., Vivier, E. Tags: Invited review Source Type: research
