Involvement of histamine 4 receptor in the pathogenesis and progression of rheumatoid arthritis
Rheumatoid arthritis (RA) is one of the major autoimmune diseases with a global prevalence. Despite significant research into this disease, no drugs with acceptable safety profiles are yet available for its treatment. We investigated the possible anti-arthritic effects of the 4-methylhistamine (4-MeH) histamine 4 receptor (H4R) agonist and the JNJ77777120 (JNJ) H4R antagonist to explore the role of H4R in a mouse model of collagen antibody-induced arthritis (CAIA). Arthritis was induced via intravenous (tail vein) injection of Balb/c mice with a 5-clone cocktail of mAbs against collagen type II, followed by LPS, and the ef...
Source: International Immunology - May 21, 2014 Category: Allergy & Immunology Authors: Abd-Allah, A. R. A., Ahmad, S. F., Alrashidi, I., Abdel-Hamied, H. E., Zoheir, K. M. A., Ashour, A. E., Bakheet, S. A., Attia, S. M. Tags: Original Research Source Type: research
Transendothelial migration of effector T cells across inflamed endothelial barriers does not require heparan sulfate proteoglycans
Leukocyte diapedesis is a chemotactic multistep process that requires optimal chemoattractant presentation by the endothelial barrier. Recent studies have described a critical role for heparan sulfate glycosaminoglycans (HSGAGs) in the presentation and functions of chemokines essential for lymphocyte interactions with the lymph node vasculature. We wished to test whether HS expression by a prototypic endothelial cell type, i.e. human umbilical vein endothelial cells (HUVECs), is critical for their ability to support neutrophil and lymphocyte adhesion and transendothelial migration (TEM) under shear flow. We found that HUVE...
Source: International Immunology - May 21, 2014 Category: Allergy & Immunology Authors: Stoler-Barak, L., Barzilai, S., Zauberman, A., Alon, R. Tags: featured content Source Type: research
The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane
TLR4/MD-2 senses lipid A, activating the MyD88-signaling pathway on the plasma membrane and the TRIF-signaling pathway after CD14-mediated TLR4/MD-2 internalization into endosomes. Monophosphoryl lipid A (MPL), a detoxified derivative of lipid A, is weaker than lipid A in activating the MyD88-dependent pathway. Little is known, however, about mechanisms underlying the attenuated activation of MyD88-dependent pathways. We here show that MPL was impaired in induction of CD14-dependent TLR4/MD-2 dimerization compared with lipid A. Impaired TLR4/MD-2 dimerization decreased CD14-mediated TNFα production. In contrast, MPL ...
Source: International Immunology - May 21, 2014 Category: Allergy & Immunology Authors: Tanimura, N., Saitoh, S.-i., Ohto, U., Akashi-Takamura, S., Fujimoto, Y., Fukase, K., Shimizu, T., Miyake, K. Tags: Original Research Source Type: research
In This Issue
(Source: International Immunology)
Source: International Immunology - May 21, 2014 Category: Allergy & Immunology Tags: In This Issue Source Type: research
Table of Contents
(Source: International Immunology)
Source: International Immunology - May 21, 2014 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
