Subscriptions
(Source: International Immunology)
Source: International Immunology - August 26, 2015 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Cover
(Source: International Immunology)
Source: International Immunology - August 26, 2015 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
The aryl hydrocarbon receptor/microRNA-212/132 axis in T cells regulates IL-10 production to maintain intestinal homeostasis
Aryl hydrocarbon receptor (Ahr), a transcription factor, plays a critical role in autoimmune inflammation of the intestine. In addition, microRNAs (miRNAs), small non-coding oligonucleotides, mediate pathogenesis of inflammatory bowel diseases (IBD). However, the precise mechanism and interactions of these molecules in IBD pathogenesis have not yet been investigated. We analyzed the role of Ahr and Ahr-regulated miRNAs in colonic inflammation. Our results show that deficiency of Ahr in intestinal epithelial cells in mice exacerbated inflammation in dextran sodium sulfate-induced colitis. Deletion of Ahr in T cells attenuat...
Source: International Immunology - July 30, 2015 Category: Allergy & Immunology Authors: Chinen, I., Nakahama, T., Kimura, A., Nguyen, N. T., Takemori, H., Kumagai, A., Kayama, H., Takeda, K., Lee, S., Hanieh, H., Ripley, B., Millrine, D., Dubey, P. K., Nyati, K. K., Fujii-Kuriyama, Y., Chowdhury, K., Kishimoto, T. Tags: featured content Source Type: research
Fine-tuning of T-cell development by the CD3{gamma} di-leucine-based TCR-sorting motif
In conclusion, our study identifies an important role of the CD3 diL motif in T-cell development most probably mediated by its fine-tuning of pre-TCR and TCR expression, down-regulation and signaling. (Source: International Immunology)
Source: International Immunology - July 30, 2015 Category: Allergy & Immunology Authors: Lauritsen, J. P. H., Boding, L., Buus, T. B., Kongsbak, M., Levring, T. B., Rode, A. K. O., Bonefeld, C. M., Geisler, C. Tags: Original Research Source Type: research
Enterococcus faecalis lipoteichoic acid suppresses Aggregatibacter actinomycetemcomitans lipopolysaccharide-induced IL-8 expression in human periodontal ligament cells
In this study, we investigated the interaction between Aa.LPS and Ef.LTA on IL-8 expression in human periodontal ligament (PDL) cells. Aa.LPS, but not Ef.LTA, substantially induced IL-8 expression at the protein and mRNA levels. Interestingly, Ef.LTA suppressed Aa.LPS-induced IL-8 expression without affecting the binding of Aa.LPS to Toll-like receptor (TLR) 4. Ef.LTA reduced Aa.LPS-induced phosphorylation of mitogen-activated protein kinases, including ERK, JNK and p38 kinase. Furthermore, Ef.LTA inhibited the Aa.LPS-induced transcriptional activities of the activating protein 1, CCAAT/enhancer-binding protein and nuclear...
Source: International Immunology - July 30, 2015 Category: Allergy & Immunology Authors: Im, J., Baik, J. E., Kim, K. W., Kang, S.-S., Jeon, J. H., Park, O.-J., Kim, H. Y., Kum, K.-Y., Yun, C.-H., Han, S. H. Tags: Original Research Source Type: research
A novel tetravalent formulation combining the four aggregated domain III-capsid proteins from dengue viruses induces a functional immune response in mice and monkeys
Our group developed a subunit vaccine candidate against dengue virus based on two different viral regions: the domain III of the envelope protein and the capsid protein. The novel chimeric protein from dengue-2 virus [domain III-capsid (DIIIC-2)], when presented as aggregated incorporating oligodeoxynucleotides, induced anti-viral and neutralizing antibodies, a cellular immune response and conferred significant protection to mice and monkeys. The remaining constructs were already obtained and properly characterized. Based on this evidence, this work was aimed at assessing the immune response in mice of the chimeric protein...
Source: International Immunology - July 30, 2015 Category: Allergy & Immunology Authors: Suzarte, E., Gil, L., Valdes, I., Marcos, E., Lazo, L., Izquierdo, A., Garcia, A., Lopez, L., Alvarez, M., Perez, Y., Castro, J., Romero, Y., Guzman, M. G., Guillen, G., Hermida, L. Tags: Original Research Source Type: research
In This Issue
(Source: International Immunology)
Source: International Immunology - July 30, 2015 Category: Allergy & Immunology Tags: In This Issue Source Type: research
Table of Contents
(Source: International Immunology)
Source: International Immunology - July 30, 2015 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Subscriptions
(Source: International Immunology)
Source: International Immunology - July 30, 2015 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Cover
(Source: International Immunology)
Source: International Immunology - July 30, 2015 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Role of zinc-finger anti-viral protein in host defense against Sindbis virus
Accumulating evidence indicates that type I interferon (IFN) mediates the host protective response to RNA viruses. However, the anti-viral effector molecules involved in this response have not been fully identified. Here, we show that zinc-finger anti-viral protein (ZAP), an IFN-inducible gene, plays a critical role in the elimination of Sindbis virus (SINV) in vitro and in vivo. The loss of ZAP greatly enhances the replication of SINV but does not inhibit type I IFN production in primary mouse embryonic fibroblasts (MEFs). ZAP binds and destabilizes SINV RNA, thereby suppressing the replication of SINV. Type I IFN fails t...
Source: International Immunology - June 29, 2015 Category: Allergy & Immunology Authors: Kozaki, T., Takahama, M., Misawa, T., Matsuura, Y., Akira, S., Saitoh, T. Tags: Original Research Source Type: research
Human CD43+ B cells are closely related not only to memory B cells phenotypically but also to plasmablasts developmentally in healthy individuals
CD20+CD27+CD43+ B (CD43+ B) cells have been newly defined among PBMCs and proposed to be human B1 cells. However, it is controversial as to whether they are orthologs of murine B1 cells and how they are related to other B-cell populations, particularly CD20+CD27+CD43– memory B cells and CD20lowCD27highCD43high plasmablasts. Our objective is to identify phenotypically the position of CD43+ B cells among peripheral B-lineage cell compartments in healthy donors, with reference to B-cell subsets from patients with systemic lupus erythematosus (SLE). We found that CD43+ B cells among PBMCs from healthy subjects were indis...
Source: International Immunology - June 29, 2015 Category: Allergy & Immunology Authors: Inui, M., Hirota, S., Hirano, K., Fujii, H., Sugahara-Tobinai, A., Ishii, T., Harigae, H., Takai, T. Tags: Original Research Source Type: research
Dimethyl fumarate suppresses Theiler's murine encephalomyelitis virus-induced demyelinating disease by modifying the Nrf2-Keap1 pathway
Dimethyl fumarate (DMF) is a modifier of the nuclear factor (erythroid-derived 2)-2 (Nrf2)-kelch-like ECH-associated protein 1 (Keap1) pathway. DMF treatment in the effector phase significantly suppressed the development of Theiler’s murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) both clinically and histologically. DMF treatment leads to an enhanced Nrf2 antioxidant response in TMEV-IDD mice. DMF treatment in the effector phase significantly suppressed the level of IL-17A mRNA. DMF is known to inhibit differentiation of T helper 17 (Th17) cells via suppressing NF-B. Taken together, our data s...
Source: International Immunology - June 29, 2015 Category: Allergy & Immunology Authors: Kobayashi, K., Tomiki, H., Inaba, Y., Ichikawa, M., Kim, B. S., Koh, C.-S. Tags: Original Research Source Type: research
Experimental myositis inducible with transfer of dendritic cells presenting a skeletal muscle C protein-derived CD8 epitope peptide
It is suggested that polymyositis, an autoimmune inflammatory myopathy, is mediated by autoaggressive CD8 T cells. Skeletal muscle C protein is a self-antigen that induces C protein-induced myositis, a murine model of polymyositis. To establish a new murine model of myositis inducible with a single CD8 T-cell epitope peptide that derives from the C protein, three internet-based prediction systems were employed to identify 24 candidate peptides of the immunogenic fragment of the C protein and bind theoretically to major histocompatibility complex class I molecules of C57BL/6 (B6) mice. RMA-S cell assay revealed that a HILIY...
Source: International Immunology - June 29, 2015 Category: Allergy & Immunology Authors: Okiyama, N., Hasegawa, H., Oida, T., Hirata, S., Yokozeki, H., Fujimoto, M., Miyasaka, N., Kohsaka, H. Tags: Short communication Source Type: research
Lack of IL-17 signaling decreases liver fibrosis in murine schistosomiasis japonica
In this study, we investigated liver fibrosis in wild-type (WT) and IL-17RA–/– mice upon S. japonicum infection. Hepatic IL-17A, IL-17C, IL-17E (IL-25), IL-17F, IL-17RA, IL-17RB and IL-17RC transcript levels were determined by RT-PCR. IL-17A+ cells were analyzed by flow cytometry and confocal microscopy among granuloma cells. Immunostaining of IL-17R was performed on liver sections. Collagen deposition was assessed by Van Gieson’s staining. IL-17A, IL-17C, IL-17E, IL-17F, IL-17RA and IL-17RC mRNA levels were dramatically increased in fibrotic livers. Among granuloma cells, CD3+ and CD3– lymphocytes,...
Source: International Immunology - June 29, 2015 Category: Allergy & Immunology Authors: Zhang, Y., Huang, D., Gao, W., Yan, J., Zhou, W., Hou, X., Liu, M., Ren, C., Wang, S., Shen, J. Tags: Original Research Source Type: research
