In This Issue
(Source: International Immunology)
Source: International Immunology - June 29, 2015 Category: Allergy & Immunology Tags: In This Issue Source Type: research
Table of Contents
(Source: International Immunology)
Source: International Immunology - June 29, 2015 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
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(Source: International Immunology)
Source: International Immunology - June 29, 2015 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Cover
(Source: International Immunology)
Source: International Immunology - June 29, 2015 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Negative regulation of DSS-induced experimental colitis by PILR{alpha}
Inflammatory bowel disease is thought to be a complex multifactorial disease, in which an increased inflammatory response plays an important role. Paired immunoglobulin-like type 2 receptor α (PILRα), well conserved in almost all mammals, is an inhibitory receptor containing immunoreceptor tyrosine-based inhibitory motifs in the cytoplasmic domain. PILRα is mainly expressed on myeloid cells and plays an important role in the regulation of inflammation. In the present study, we investigated the function of PILRα in inflammatory bowel disease using PILRα-deficient mice. When mice were orally adm...
Source: International Immunology - May 22, 2015 Category: Allergy & Immunology Authors: Kishida, K., Kohyama, M., Kurashima, Y., Kogure, Y., Wang, J., Hirayasu, K., Suenaga, T., Kiyono, H., Kunisawa, J., Arase, H. Tags: featured content Source Type: research
Human placenta: relative content of antibodies of different classes and subclasses (IgG1-IgG4) containing lambda- and kappa-light chains and chimeric lambda-kappa-immunoglobulins
The specific organ placenta is much more than a filter: it is an organ that protects, feeds and regulates the growth of the embryo. Affinity chromatography, ELISA, SDS–PAGE and matrix-assisted laser desorption ionization mass spectrometry were used. Using 10 intact human placentas deprived of blood, a quantitative analysis of average relative content [% of total immunoglobulins (Igs)] was carried out for the first time: (92.7), IgA (2.4), IgM (2.5), kappa-antibodies (51.4), lambda-antibodies (48.6), IgG1 (47.0), IgG2 (39.5), IgG3 (8.8) and IgG4 (4.3). It was shown for the first time that placenta contains sIgA (2.5%)...
Source: International Immunology - May 22, 2015 Category: Allergy & Immunology Authors: Lekchnov, E. A., Sedykh, S. E., Dmitrenok, P. S., Buneva, V. N., Nevinsky, G. A. Tags: Original Research Source Type: research
Association between sHLA-G and HLA-G 14-bp deletion/insertion polymorphism in Crohn's disease
The aim of this study was to evaluate the association between the HLA-G 14-bp deletion/insertion (Del/Ins) polymorphism and soluble (s) HLA-G production in patients with Crohn’s disease (CD). We analyzed also the sHLA-G molecules by ELISA and western blot in plasma samples. Among unselected patients, the 14-bp Del/Ins polymorphism was not significantly associated with increased CD risk neither for alleles (P = 0.371) nor for genotypes (P = 0.625). However, a significant association was reported between the 14-bp Del/Ins polymorphism and CD, in particular in young-onset CD patients for alleles [P = 0.020, odds ratio (...
Source: International Immunology - May 22, 2015 Category: Allergy & Immunology Authors: Zidi, I., Ben Yahia, H., Bortolotti, D., Mouelhi, L., Laaribi, A. B., Ayadi, S., Zidi, N., Houissa, F., Debbech, R., Boudabous, A., Najjar, T., Di Luca, D., Rizzo, R. Tags: Original Research Source Type: research
Analysis of IL-22 contribution to hepcidin induction and hypoferremia during the response to LPS in vivo
The anaemia of chronic disease (ACD) results from inflammation-mediated up-regulation of the iron regulatory hormone hepcidin, with the consequent sequestration of iron limiting its availability for erythropoiesis. The inflammatory cytokine IL-6, a regulator of hepcidin, has been implicated in this process. Recent in vivo and in vitro studies indicate that IL-22 is also able to stimulate hepcidin expression. We aimed to determine if IL-22 had a role in causing the hypoferremia associated with the inflammatory response. Wild-type and Il22-knockout mice were subjected to an acute inflammatory stimulus via administration of L...
Source: International Immunology - May 22, 2015 Category: Allergy & Immunology Authors: Wallace, D. F., Subramaniam, V. N. Tags: Short communication Source Type: research
Dissecting the formation, structure and barrier function of the stratum corneum
The skin is the largest organ of the mammalian body. The outermost layer of mammalian skin, the stratum corneum (SC) of the epidermis, consists of piles of dead corneocytes that are the end-products of terminal differentiation of epidermal keratinocytes. The SC performs a crucial barrier function of epidermis. Langerhans cells, when activated, extend their dendrites through tight junctions just beneath the SC to capture external antigens. Recently, knowledge of the biology of corneocytes (‘corneobiology’) has progressed rapidly and many key factors that modulate its barrier function have been identified and cha...
Source: International Immunology - May 22, 2015 Category: Allergy & Immunology Authors: Matsui, T., Amagai, M. Tags: Invited review Source Type: research
Outstanding Merit Award for 2014
(Source: International Immunology)
Source: International Immunology - May 22, 2015 Category: Allergy & Immunology Tags: Award Source Type: research
In This Issue
(Source: International Immunology)
Source: International Immunology - May 22, 2015 Category: Allergy & Immunology Tags: In This Issue Source Type: research
Table of Contents
(Source: International Immunology)
Source: International Immunology - May 22, 2015 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Subscriptions
(Source: International Immunology)
Source: International Immunology - May 22, 2015 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Cover
(Source: International Immunology)
Source: International Immunology - May 22, 2015 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
CD1d-dependent expansion of NKT follicular helper cells in vivo and in vitro is a product of cellular proliferation and differentiation
NKT follicular helper cells (NKTfh cells) are a recently discovered functional subset of CD1d-restricted NKT cells. Given the potential for NKTfh cells to promote specific antibody responses and germinal center reactions, there is much interest in determining the conditions under which NKTfh cells proliferate and/or differentiate in vivo and in vitro. We confirm that NKTfh cells expressing the canonical semi-invariant Vα14 TCR were CXCR5+/ICOS+/PD-1+/Bcl6+ and increased in number following administration of the CD1d-binding glycolipid α-galactosylceramide (α-GC) to C57Bl/6 mice. We show that the α-G...
Source: International Immunology - April 22, 2015 Category: Allergy & Immunology Authors: Rampuria, P., Lang, M. L. Tags: Original Research Source Type: research
