IgG4-related disease and its pathogenesis--cross-talk between innate and acquired immunity
IgG4-related disease (IgG4-RD) is a novel clinical entity proposed in Japan in the 21th century and is attracting strong attention over the world. The characteristic manifestations of IgG4-RD are increased serum IgG4 concentration and tumefaction by IgG4+ plasma cells. Although the clinical manifestations in various organs have been established, the pathogenesis of IgG4-RD is still unknown. Recently, many reports of aberrant acquired immunity such as Th2-diminated immune responses have been published. However, many questions still remain, including questions about the pathogenesis of IgG4-RD and the roles of IgG4. In this ...
Source: International Immunology - October 18, 2014 Category: Allergy & Immunology Authors: Umehara, H., Nakajima, A., Nakamura, T., Kawanami, T., Tanaka, M., Dong, L., Kawano, M. Tags: Invited review Source Type: research
In This Issue
(Source: International Immunology)
Source: International Immunology - October 18, 2014 Category: Allergy & Immunology Tags: In This Issue Source Type: research
Table of Contents
(Source: International Immunology)
Source: International Immunology - October 18, 2014 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Subscriptions
(Source: International Immunology)
Source: International Immunology - October 18, 2014 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Cover
(Source: International Immunology)
Source: International Immunology - October 18, 2014 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Dynamics of T-cell IFN-{gamma} and miR-29a expression during active pulmonary tuberculosis
IFN- is crucial for protection against Mycobacterium tuberculosis. miR-29 was recently shown to non-redundantly inhibit IFN-. Here, we investigated IFN- and miR-29a expression dynamics of CD4+ T cells from patients during active tuberculosis (TB) (n = 32) and in household contacts who were latently M. tuberculosis infected (n = 19) from Ghana. Whereas M. tuberculosis-specific IFN- expression was similar during TB chemotherapy, superantigen stimulation indicated generally impaired IFN- expression in TB patients. No interdependency between miR-29a and IFN- expression of T cells was observed. However, miR-29a was differential...
Source: International Immunology - September 20, 2014 Category: Allergy & Immunology Authors: Afum-Adjei Awuah, A., Ueberberg, B., Owusu-Dabo, E., Frempong, M., Jacobsen, M. Tags: Short communication Source Type: research
Opinion: uracil DNA glycosylase (UNG) plays distinct and non-canonical roles in somatic hypermutation and class switch recombination
Activation-induced cytidine deaminase (AID) is essential to class switch recombination (CSR) and somatic hypermutation (SHM). Uracil DNA glycosylase (UNG), a member of the base excision repair complex, is required for CSR. The role of UNG in CSR and SHM is extremely controversial. AID deficiency in mice abolishes both CSR and SHM, while UNG-deficient mice have drastically reduced CSR but augmented SHM raising a possibility of differential functions of UNG in CSR and SHM. Interestingly, UNG has been associated with a CSR-specific repair adapter protein Brd4, which interacts with acetyl histone 4, H2AX and 53BP1 to promote n...
Source: International Immunology - September 20, 2014 Category: Allergy & Immunology Authors: Yousif, A. S., Stanlie, A., Begum, N. A., Honjo, T. Tags: Invited review Source Type: research
Lipopeptides are signaled by Toll-like receptor 1, 2 and 6 in endolysosomes
In this study, we established mAbs to TLR1, 2 and 6. TLR1, 2 and 6 were expressed on the surface of B cells, monocytes and dendritic cells in a manner dependent on a TLR-specific chaperone PRAT4A (protein associated with TLR4 A). Cell surface localization of TLR1 or TLR6 was not necessarily required for TLR2 response. Furthermore, a dynamin inhibitor ‘Dynasore’ abolished the lipopeptide responses by preventing lipopeptide internalization into LAMP-1 and LAMP-2 positive compartments. Our findings suggest that lipopeptides elicit TLR1/2 and TLR2/6 signaling in the endolysosomes, but not on the cell surface. (Sour...
Source: International Immunology - September 20, 2014 Category: Allergy & Immunology Authors: Motoi, Y., Shibata, T., Takahashi, K., Kanno, A., Murakami, Y., Li, X., Kasahara, T., Miyake, K. Tags: Original Research Source Type: research
Generation of induced pluripotent stem cell-derived mice by reprogramming of a mature NKT cell
NKT cells are characterized by their expression of an NKT-cell-specific invariant antigen-receptor α chain encoded by Vα14Jα18 gene segments. These NKT cells bridge the innate and acquired immune systems to mediate effective and augmented responses; however, the limited number of NKT cells in vivo hampers their analysis. Here, two lines of induced pluripotent stem cell-derived mice (NKT-iPSC-derived mice) were generated by reprogramming of mature NKT cells, where one harbors both rearranged Vα14Jα18 and Vβ7 genes and the other carries rearranged Vα14Jα18 on both alleles but ge...
Source: International Immunology - September 20, 2014 Category: Allergy & Immunology Authors: Ren, Y., Dashtsoodol, N., Watarai, H., Koseki, H., Quan, C., Taniguchi, M. Tags: Original Research Source Type: research
The role of basophils and proallergic cytokines, TSLP and IL-33, in cutaneously sensitized food allergy
Cutaneous sensitization with a food antigen before its consumption elicits the development of food allergy. Here, we report the site- and stage-dependent roles of basophils and proallergic cytokines, thymic stromal lymphopoietin (TSLP) and IL-33, in a mouse model of food allergy initially sensitized cutaneously with the food antigen. Mice were epicutaneously sensitized with the food antigen ovalbumin (OVA) followed by oral challenge with OVA. Epicutaneously sensitized mice produced OVA-specific IgE and developed IgE-dependent anaphylaxis after oral challenge. Basophil-depleted or TSLP–receptor-deficient mice did not ...
Source: International Immunology - September 20, 2014 Category: Allergy & Immunology Authors: Muto, T., Fukuoka, A., Kabashima, K., Ziegler, S. F., Nakanishi, K., Matsushita, K., Yoshimoto, T. Tags: Original Research Source Type: research
Polyethyleneimine is a potent systemic adjuvant for glycoprotein antigens
Polyethyleneimine (PEI) is an organic polycation used extensively as a gene and DNA vaccine delivery reagent. Although the DNA targeting activity of PEI is well documented, its immune activating activity is not. We recently reported that PEI has robust mucosal adjuvanticity when administered intranasally with glycoprotein antigens. Here, we show that PEI has strong immune activating activity after systemic delivery. PEI administered subcutaneously with viral glycoprotein (HIV-1 gp140) enhanced antigen-specific serum IgG production in the context of mixed Th1/Th2-type immunity. PEI elicited higher titers of both antigen bin...
Source: International Immunology - September 20, 2014 Category: Allergy & Immunology Authors: Sheppard, N. C., Brinckmann, S. A., Gartlan, K. H., Puthia, M., Svanborg, C., Krashias, G., Eisenbarth, S. C., Flavell, R. A., Sattentau, Q. J., Wegmann, F. Tags: featured content Source Type: research
In This Issue
(Source: International Immunology)
Source: International Immunology - September 20, 2014 Category: Allergy & Immunology Tags: In This Issue Source Type: research
Table of Contents
(Source: International Immunology)
Source: International Immunology - September 20, 2014 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Subscriptions
(Source: International Immunology)
Source: International Immunology - September 20, 2014 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Cover
(Source: International Immunology)
Source: International Immunology - September 20, 2014 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
