Heterogeneity and diversity of group 3 innate lymphoid cells: new cells on the block
Innate lymphoid cells (ILCs) are a newly identified subset of innate cells that play fundamentally crucial roles for early immune defense at mucosal and non-mucosal sites. ILCs consist of ILC1s, ILC2s and ILC3s, which each have distinct transcription factors controlling their development and function. Interestingly, each of the ILC subsets represents the innate counterparts of CD4+ helper T-cell subsets Th1, Th2 and Th17 on the basis of transcriptional regulation. ILC1s that produce IFN- or TNF-α, ILC2s that produce Th2-type cytokines mainly such as IL-5 or IL-13 and ILC3s have been recently reported and reviewed in ...
Source: International Immunology - December 28, 2015 Category: Allergy & Immunology Authors: Satoh-Takayama, N. Tags: Invited review Source Type: research
Inflammatory group 2 innate lymphoid cells
Group 2 innate lymphoid cells (ILC2 cells) are able to produce type 2 cytokines and to mediate type 2 immune protection and tissue homeostasis. ILC2 cells have often been considered to be a single set of cells that respond to IL-33 and/or IL-25. Recent evidence now indicates that ILC2 cells can be grouped into two distinct subsets: homeostatic or natural ILC2s (nILC2 cells); and inflammatory ILC2 cells (iILC2 cells). nILC2 cells reside in barrier tissues and primarily respond to IL-33. They play critical roles not only in immune protection but also in tissue repair and beige fat biogenesis. iILC2 cells are not present in p...
Source: International Immunology - December 28, 2015 Category: Allergy & Immunology Authors: Huang, Y., Paul, W. E. Tags: Invited review Source Type: research
Group 2 innate lymphoid cells in disease
Group 2 innate lymphoid cells (ILC2) are now recognized as an important innate source of type-2 effector cytokines. Although initially associated with mucosal tissues, it is clear that ILC2 are present in diverse anatomical locations. The function of ILC2 at these sites is equally varied, and although ILC2 represent a relatively minor population, they are fundamentally important regulators of innate and adaptive immune processes. As such, there is much interest to understand the role of ILC2 in diseases with a type-2 inflammatory component. This review explores the known roles of ILC2 in disease, and the diseases that show...
Source: International Immunology - December 28, 2015 Category: Allergy & Immunology Authors: Halim, T. Y. F. Tags: Invited review Source Type: research
Differentiation and diversity of subsets in group 1 innate lymphoid cells
NK cells were first identified in 1975 and represent the prototypical group 1 innate lymphoid cell (ILC). More recently, the discovery of new members of the ILC family has highlighted the complexity of this innate lymphoid lineage. Importantly, it has been recognized that different subsets exist within the group 1 ILC, which have potential roles in mediating immune protection and immunosurveillance, and in regulating tissue homeostasis and inflammation. Here, we review the developmental relationships between the different group 1 ILC, which have been identified to date and discuss how heterogeneity within this expanding fa...
Source: International Immunology - December 28, 2015 Category: Allergy & Immunology Authors: Seillet, C., Belz, G. T. Tags: Invited review Source Type: research
Introduction: Innate Lymphoid Cells Special Issue
(Source: International Immunology)
Source: International Immunology - December 28, 2015 Category: Allergy & Immunology Authors: Koyasu, S. Tags: Introduction Source Type: research
Table of Contents
(Source: International Immunology)
Source: International Immunology - December 28, 2015 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Subscriptions
(Source: International Immunology)
Source: International Immunology - December 28, 2015 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Cover
(Source: International Immunology)
Source: International Immunology - December 28, 2015 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Systemic lupus erythematosus: molecular cloning and analysis of recombinant monoclonal kappa light chain NGTA2-Me-pro-ChTr possessing two different activities--trypsin-like and metalloprotease
Polyclonal antibodies hydrolyzing myelin basic protein (MBP) can play an important role in the pathogenesis of multiple sclerosis and systemic lupus erythematosus (SLE). An immunoglobulin light chain phagemid library derived from peripheral blood lymphocytes of patients with SLE was used. The small pools of phage particles displaying light chains with different affinity for MBP were isolated by affinity chromatography on MBP-Sepharose. The fraction eluted with 0.5M NaCl was used for preparation of individual monoclonal light chains (MLChs, 26–27kDa). The clones were expressed in Escherichia coli in a soluble form; ML...
Source: International Immunology - November 25, 2015 Category: Allergy & Immunology Authors: Timofeeva, A. M., Ivanisenko, N. V., Buneva, V. N., Nevinsky, G. A. Tags: Original Research Source Type: research
Oxaliplatin regulates expression of stress ligands in ovarian cancer cells and modulates their susceptibility to natural killer cell-mediated cytotoxicity
Selected cytotoxic chemicals can provoke the immune system to recognize and destroy malignant tumors. Most of the studies on immunogenic cell death are focused on the signals that operate on a series of receptors expressed by dendritic cells to induce tumor antigen-specific T-cell responses. Here, we explored the effects of oxaliplatin, an immunogenic cell death inducer, on the induction of stress ligands and promotion of natural killer (NK) cell-mediated cytotoxicity in human ovarian cancer cells. The results indicated that treatment of tumor cells with oxaliplatin induced the production of type I interferons and chemokin...
Source: International Immunology - November 25, 2015 Category: Allergy & Immunology Authors: Siew, Y.-Y., Neo, S.-Y., Yew, H.-C., Lim, S.-W., Ng, Y.-C., Lew, S.-M., Seetoh, W.-G., Seow, S.-V., Koh, H.-L. Tags: Original Research Source Type: research
An asymmetric antibody repertoire is shaped between plasmablasts and plasma cells after secondary immunization with (4-hydroxy-3-nitrophenyl)acetyl chicken {gamma}-globulin
Studies on the structural basis of antibody affinity maturation have been carried out by measuring the affinity of secreted antibodies, and information on structures has often been obtained from nucleotide sequences of BCRs of memory B cells. We considered it important to establish whether the repertoire of secreted antibodies from plasma cells is really in accord with that of BCRs on memory B cells at the same time points post-immunization. We isolated plasma cells secreting antibodies specific to (4-hydroxy-3-nitrophenyl)acetyl (NP) hapten by affinity matrix technology using biotin–anti-CD138 and streptavidin&ndash...
Source: International Immunology - November 25, 2015 Category: Allergy & Immunology Authors: Tashiro, Y., Murakami, A., Goizuka, R., Shimizu, T., Kishimoto, H., Azuma, T. Tags: featured content Source Type: research
Melatonin inhibits granulocyte adhesion to ICAM via MT3/QR2 and MT2 receptors
In conclusion, we show that melatonin suppresses granulocyte migration via endothelium by acting directly on granulocytes. (Source: International Immunology)
Source: International Immunology - November 25, 2015 Category: Allergy & Immunology Authors: Cernysiov, V., Mauricas, M., Girkontaite, I. Tags: Original Research Source Type: research
In This Issue
(Source: International Immunology)
Source: International Immunology - November 25, 2015 Category: Allergy & Immunology Tags: In This Issue Source Type: research
Table of Contents
(Source: International Immunology)
Source: International Immunology - November 25, 2015 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Subscriptions
(Source: International Immunology)
Source: International Immunology - November 25, 2015 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
