Phenotype, proliferation and apoptosis of B lymphocytes in hemodialysis patients treated with recombinant human erythropoietin
One of the major causes of disorders of the immune response in patients undergoing hemodialysis (HD) is weaker activity of their helper T lymphocytes (Th cells), mainly reduced proliferative capacity associated with decreased expression of key surface antigens. Since cooperation between Th and B lymphocytes is essential for B cell function, changes in Th cell phenotype and ability to proliferate or produce cytokines could directly translate into an impaired humoral response. Therefore, we investigated the T cell-dependent activity of B cells in HD patients focusing mainly on their proliferative kinetics, susceptibility to ...
Source: International Immunology - October 27, 2016 Category: Allergy & Immunology Authors: Jasiulewicz, A., Lisowska, K. A., Debska-Slizien, A., Witkowski, J. M. Tags: Original Research Source Type: research
Important Announcement
(Source: International Immunology)
Source: International Immunology - October 27, 2016 Category: Allergy & Immunology Authors: Akira, S. Tags: Announcement Source Type: research
In This Issue
(Source: International Immunology)
Source: International Immunology - October 27, 2016 Category: Allergy & Immunology Tags: In This Issue Source Type: research
Table of Contents
(Source: International Immunology)
Source: International Immunology - October 27, 2016 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
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(Source: International Immunology)
Source: International Immunology - October 27, 2016 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Cover
(Source: International Immunology)
Source: International Immunology - October 27, 2016 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Rapamycin results in Bim-mediated loss of thymic regulatory T cells during development in organ culture
Thymus-derived regulatory T cells (Tregs) are essential for the maintenance of immunological tolerance. Diverse signalling pathways contribute to thymic Treg cells (tTregs) development; however, the role of mammalian target of rapamycin (mTOR) remains unclear. Rapamycin is a well-characterized inhibitor of mTOR complex 1 signalling and a potent inducer of Treg cells in the periphery. However, the effect of rapamycin on the development of tTregs is poorly defined. Here we have used thymic organ culture to investigate the effect of rapamycin on tTreg development. We show that, contrary to its effect in the periphery, rapamyc...
Source: International Immunology - September 29, 2016 Category: Allergy & Immunology Authors: Overall, S. A., van Driel, I. R., Gleeson, P. A. Tags: Short communication Source Type: research
Inflammatory responses increase secretion of MD-1 protein
Radioprotective 105 (RP105) is a type I transmembrane protein, which associates with a glycoprotein, MD-1. Monoclonal antibody (mAb)-mediated ligation of RP105/MD-1 robustly activates B cells. RP105/MD-1 is structurally similar to Toll-like receptor 4 (TLR4)/MD-2. B-cell responses to TLR2 and TLR4/MD-2 ligands are impaired in the absence of RP105 or MD-1. In addition to RP105/MD-1, MD-1 alone is secreted. The structure of MD-1 shows that MD-1 has a hydrophobic cavity that directly binds to phospholipids. Little is known, however, about a ligand for MD-1 and the role of MD-1 in vivo. To study the role of RP105/MD-1 and MD-1...
Source: International Immunology - September 29, 2016 Category: Allergy & Immunology Authors: Thomas Jennings, R., Odkhuu, E., Nakashima, A., Morita, N., Kobayashi, T., Yamai, I., Tanaka, M., Suganami, T., Haga, S., Ozaki, M., Watanabe, Y., Nagai, Y., Takatsu, K., Kikuchi-Ueda, T., Ichimonji, I., Ogawa, Y., Takagi, H., Yamazaki, T., Miyake, K., Ak Tags: Original Research Source Type: research
IL-10-producing lung interstitial macrophages prevent neutrophilic asthma
In this study, we characterized AMs and IMs in healthy and inflammatory conditions. Pulmonary IMs constitutively produce the anti-inflammatory cytokine IL-10 through activation of the TLR4/MyD88 pathway in a microbiota-independent manner. In addition to IMs, Foxp3+ Treg cells show persistent IL-10 expression in the lung, with IL-10-producing IMs more prevalent than Foxp3+ Treg cells. IMs, but not Foxp3+ Treg cells, increased IL-10 production in house dust mite (HDM)-challenged mice, a model of human asthma. HDM-challenged Il10 –/– mice exhibited severe lung pathology characterized by neutrophilia compared wit...
Source: International Immunology - September 29, 2016 Category: Allergy & Immunology Authors: Kawano, H., Kayama, H., Nakama, T., Hashimoto, T., Umemoto, E., Takeda, K. Tags: featured content Source Type: research
A novel role of MMP-13 for murine DC function: its inhibition dampens T-cell activation
Dendritic cells (DCs) have been shown to express matrix metalloproteinase 13 (MMP-13), but little is known about its specific function in DCs and its role in inflammatory conditions. In the present study, we describe a novel role of MMP-13 in regulating the immunostimulatory function of murine DCs through moderating MHC-I surface presentation, endocytosis and cytokine/chemokine secretion. MMP-13 expression was confirmed in bone marrow-derived DCs at both the mRNA and the protein level and, furthermore, at the activity level. Remarkably, LPS treatment strongly enhanced MMP-13 mRNA expression as well as MMP-13 activity, indi...
Source: International Immunology - September 29, 2016 Category: Allergy & Immunology Authors: Bartmann, J., Frankenberger, M., Neurohr, C., Eickelberg, O., Noessner, E., von Wulffen, W. Tags: Original Research Source Type: research
In This Issue
(Source: International Immunology)
Source: International Immunology - September 29, 2016 Category: Allergy & Immunology Tags: In This Issue Source Type: research
Table of Contents
(Source: International Immunology)
Source: International Immunology - September 29, 2016 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Subscriptions
(Source: International Immunology)
Source: International Immunology - September 29, 2016 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Cover
(Source: International Immunology)
Source: International Immunology - September 29, 2016 Category: Allergy & Immunology Tags: Cover / Standing Material Source Type: research
Lung inflammation stalls Th17-cell migration en route to the central nervous system during the development of experimental autoimmune encephalomyelitis
Recruiting pathogenic T cells to the central nervous system (CNS) is a critical step during the development of experimental autoimmune encephalomyelitis (EAE). Here, we report that the absence of autophagy and microtubule-associated protein 1A/1B-light chain 3-associated phagocytosis significantly delayed the onset of EAE in Atg7 conditional knockout (Atg7 CKO) mice in myeloid cells. T-helper cell-cell priming appeared to be normal in the Atg7 CKO mice, but the mice showed significant accumulation of Th17 cells in the lung. The data suggested that the stalling of Th17 cells in the lung en route to the CNS caused the delay....
Source: International Immunology - August 30, 2016 Category: Allergy & Immunology Authors: Kanayama, M., Danzaki, K., He, Y.-W., Shinohara, M. L. Tags: Short communication Source Type: research
