Fine-tuning of T-cell development by the CD3{gamma} di-leucine-based TCR-sorting motif

In conclusion, our study identifies an important role of the CD3 diL motif in T-cell development most probably mediated by its fine-tuning of pre-TCR and TCR expression, down-regulation and signaling.

Source: International Immunology - July 30, 2015 Category: Allergy & Immunology Authors: Lauritsen, J. P. H., Boding, L., Buus, T. B., Kongsbak, M., Levring, T. B., Rode, A. K. O., Bonefeld, C. M., Geisler, C. Tags: Original Research Source Type: research