B-CLL cells acquire APC- and CTL-like phenotypic characteristics after stimulation with CpG ODN and IL-21

In conclusion, CpG/IL-21-stimulated B-CLL cells acquire features that are reminiscent of killer dendritic cells, and which result in enhanced immunogenicity, cytotoxicity and apoptosis. Our results provide novel insights into the aberrant immune state of B-CLL cells and may establish a basis for the development of an innovative cellular vaccination approach in B-CLL.

Source: International Immunology - June 30, 2014 Category: Allergy & Immunology Authors: Hagn, M., Blackwell, S. E., Beyer, T., Ebel, V., Fabricius, D., Lindner, S., Stilgenbauer, S., Simmet, T., Tam, C., Neeson, P., Trapani, J. A., Schrezenmeier, H., Weiner, G. J., Jahrsdorfer, B. Tags: Original Research Source Type: research