Activation-induced cytidine deaminase is dispensable for virus-mediated liver and skin tumor development in mouse models

In conclusion, AID does not appear to be required for tumor development in the two virus-induced tumor mouse models tested although AID expressed in infiltrating B cells may promote inflammatory reactions in HCV core protein-induced liver pathogenesis.

Source: International Immunology - June 30, 2014 Category: Allergy & Immunology Authors: Nguyen, T., Xu, J., Chikuma, S., Hiai, H., Kinoshita, K., Moriya, K., Koike, K., Marcuzzi, G. P., Pfister, H., Honjo, T., Kobayashi, M. Tags: Original Research Source Type: research