Common allergies do not influence the prevalence of cutaneous hypersensitivity reactions to antiepileptic drugs
(Source: Epilepsy Research)
Source: Epilepsy Research - May 16, 2017 Category: Neurology Authors: Magdalena Bosak, Grzegorz Por ębski, Agnieszka Słowik, Wojciech Turaj Source Type: research
Erratum to “Efficacy and tolerability of adjunctive brivaracetam in patients with prior antiepileptic drug exposure: A post-hoc study” [Epilepsy Res. 131 (2017) 70–75]
The publisher regrets that during the publication of this article Table 6 was inadvertently laid out incorrectly. Table 6 is hereby republished with the correct layout. The publisher would like to apologise for any inconvenience caused. (Source: Epilepsy Research)
Source: Epilepsy Research - May 10, 2017 Category: Neurology Authors: Ali A. Asadi-Pooya, Michael R. Sperling, Steve Chung, Pavel Klein, Anyzeila Diaz, Sami Elmoufti, Jimmy Schiemann, John Whitesides Tags: Erratum Source Type: research
Efficacy of anticonvulsant substances in the 6Hz seizure test: comparison of two rodent species
(Source: Epilepsy Research)
Source: Epilepsy Research - May 9, 2017 Category: Neurology Authors: Elise Esneault, Guillaume Peyon, Vincent Castagn é Source Type: research
Mesial temporal lobe epilepsy diminishes functional connectivity during emotion perception
Mesial temporal lobe epilepsy (MTLE) is the most prevalent form of refractory epilepsy in adults, and is now considered as a complex network disease that affects widely distributed brain regions organized in networks in the afflicted hemisphere (Berg et al., 2010 and Jokeit et al., 1997). Consistent with structural and functional abnormalities extending far beyond the mesial temporal lobe (Bernhardt et al., 2013), deficits in neuropsychological functions relying on large-scale networks such as memory (Bell et al., 2011), language (Bartha-Doering and Trinka, 2014) and executive functions (Stretton and Thompson, 2012) are a ...
Source: Epilepsy Research - May 9, 2017 Category: Neurology Authors: Bettina K. Steiger, Angela M. Muller, Esther Spirig, Gianina Toller, Hennric Jokeit Source Type: research
Prolonged epileptiform EEG runs are associated with persistent seizures in juvenile myoclonic epilepsy
Juvenile myoclonic epilepsy (JME) is the most common form of idiopathic generalized (genetic) epilepsy (Syvertsen et al., 2017). Seizure onset usually occurs around puberty with early morning myoclonic jerks. The majority of patients develop generalized tonic-clonic seizures and 20-40% has absence seizures (Commission, 1989; Genton et al., 2013; Janz, 1989; Kasteleijn- Nolst Trenit é et al., 2013). EEG is the most useful supplementary diagnostic method. Valproate is effective in the majority of patients (Gesche et al., 2017; Penry et al., 1989), but reproductive toxicity limits its use in women. (Source: Epilepsy Research)
Source: Epilepsy Research - May 8, 2017 Category: Neurology Authors: Vibeke Arntsen, Trond Sand, Marte R. Syvertsen, Eylert Brodtkorb Source Type: research
Anticonvulsant profile of the neuroactive steroid, SGE-516, in animal models
Since the discovery of phenobarbital in 1912 and the development of benzodiazepines in the 1950s, drugs that enhance GABAergic signaling have been used for the treatment of seizure disorders (Magiorkinis et al., 2014). In addition, over a dozen new pharmacotherapies with varying mechanisms of action have been developed to treat seizures in the last twenty years. Whereas these newer therapies have generally demonstrated improved safety and tolerability, approximately one third of patients with epilepsy continue to struggle with uncontrolled seizures (Tellez-Zenteno et al., 2014). (Source: Epilepsy Research)
Source: Epilepsy Research - May 7, 2017 Category: Neurology Authors: Rebecca S. Hammond, Alison L. Althaus, Michael A. Ackley, Carla Maciag, Gabriel Martinez-Botella, Francesco G. Salituro, Albert J. Robichaud, James J. Doherty Source Type: research
Heat induced temperature dysregulation and seizures in Dravet Syndrome/GEFS+ Gabrg2+/Q390X mice
(Source: Epilepsy Research)
Source: Epilepsy Research - April 30, 2017 Category: Neurology Authors: Timothy A. Warner, Zhong Liu, Robert L. Macdonald, Jing-Qiong Kang Source Type: research
Editorial Board
(Source: Epilepsy Research)
Source: Epilepsy Research - April 28, 2017 Category: Neurology Source Type: research
Prevalence and Risk Factors of Seizure Clusters in Adult Patients with Epilepsy
(Source: Epilepsy Research)
Source: Epilepsy Research - April 27, 2017 Category: Neurology Authors: Baibing Chen, Hyunmi Choi, Lawrence J Hirsch, Austen Katz, Alexander Legge, Rebecca A Wong, Alfred Jiang, Kenneth Kato, Richard Buchsbaum, Kamil Detyniecki Source Type: research
Effect of Enzyme Inhibition on Perampanel Pharmacokinetics: Why Study Design Matters
(Source: Epilepsy Research)
Source: Epilepsy Research - April 25, 2017 Category: Neurology Authors: Barry E. Gidal, Rama Maganti, Antonio Laurenza, Haichen Yang, David A. Verbel, Edgar Schuck, Jim Ferry Source Type: research
Maximal/Exhaustive Treadmill Test Features in Patients with Temporal Lobe Epilepsy: Search for Sudden Unexpected Death Biomarkers
Epilepsy is one of the most important neurological diseases in clinical practice, being the second most common neurological disease in primary care. All over the world, around 65 million individuals suffer from epilepsy (Thurman et al., 2011) and patients with epilepsy (PWE) have a 20 to 40-fold increased risk for sudden death (Ficker et al., 1998; Mohanraj et al., 2006). In fact, Sudden Unexpected Death in Epilepsy (SUDEP) is responsible for 17 to 38% of deaths in PWE. SUDEP has been defined as the sudden, unexpected, witnessed or unwitnessed, non-traumatic, and non-drowning death in PWE, with or without evidence for a se...
Source: Epilepsy Research - April 24, 2017 Category: Neurology Authors: Guilherme L. Fialho, Arthur G. Pagani, Roger Walz, Peter Wolf, Katia Lin Source Type: research
Changes in the interictal and early postictal diffusion and perfusion magnetic resonance parameters in familial spontaneous epileptic cats
Epilepsy research - Full-length Paper (Source: Epilepsy Research)
Source: Epilepsy Research - April 23, 2017 Category: Neurology Authors: Yuji Hamamoto, Daisuke Hasegawa, Shunta Mizoguchi, Yoshihiko Yu, Masae Wada, Takayuki Kuwabara, Aki Igarashi-Fujiwara, Michio Fujita. Source Type: research
Ivabradine attenuates the anticonvulsant potency of lamotrigine, but not that of lacosamide, pregabalin and topiramate in the tonic-clonic seizure model in mice
(Source: Epilepsy Research)
Source: Epilepsy Research - April 21, 2017 Category: Neurology Authors: Katarzyna M. Sawicka, Katarzyna Za łuska, Agnieszka Wawryniuk, Karolina Załuska-Patel, Michał Szczyrek, Bartłomiej Drop, Jadwiga Daniluk, Monika Szpringer, Dorota Żółkowska, Jarogniew J. Łuszczki Source Type: research
A Survey of Medical Examiner Death Certification of Vignettes on Death in Epilepsy: Gaps in Identifying SUDEP
Sudden unexpected death in epilepsy (SUDEP) is a leading cause of death in individuals with chronic, uncontrolled epilepsy (Tomson et al., 2005, 2008). These poorly understood deaths can occur in anyone with epilepsy of any kind, and both high and low risk groups have been identified (So, 2006; Tomson et al., 2005). The specific mechanism of death is unknown for SUDEP cases and likely multifactorial, with evidence suggesting brainstem dysfunction and cardiorespiratory dysregulation as a final common pathway associated with sudden death in these individuals (de la Grandmaison, 2006; Partemi et al., 2015; So, 2008; Tu et al....
Source: Epilepsy Research - April 21, 2017 Category: Neurology Authors: Daniel S. Atherton, Gregory G. Davis, Cyndi Wright, Orrin Devinsky, Dale Hesdorffer Source Type: research
Surgical outcome of MRI-negative refractory extratemporal lobe epilepsy
(Source: Epilepsy Research)
Source: Epilepsy Research - April 20, 2017 Category: Neurology Authors: Jianguo Shi, Nuria Lacuey-Lecumberri, Samden Lhatoo Source Type: research
