Safety, efficacy and outcome-related factors of perampanel over 12 months in a real-world setting: The FYDATA study
(Source: Epilepsy Research)
Source: Epilepsy Research - August 3, 2016 Category: Neurology Authors: V. Villanueva, M. Garc és, F.J. López-González, X. Rodriguez-Osorio, M. Toledo, J. Salas-Puig, M. González-Cuevas, D. Campos, J.M. Serratosa, B. González Giráldez, J.A. Mauri, J.L. Camacho, A. Suller, M. Carreño, J.B. Gómez, J. Montoya, J. Rodrigu Source Type: research
Fit for purpose application of currently existing animal models in the discovery of novel epilepsy therapies
(Source: Epilepsy Research)
Source: Epilepsy Research - July 31, 2016 Category: Neurology Authors: Wolfgang L öscher Tags: Review article Source Type: research
Long-term outcome characteristics in mesial temporal lobe epilepsy with and without associated cortical dysplasia
(Source: Epilepsy Research)
Source: Epilepsy Research - July 31, 2016 Category: Neurology Authors: B. Schmeiser, T. Hammen, B.J. Steinhoff, J. Zentner, A. Schulze-Bonhage Source Type: research
How does vagal nerve stimulation (VNS) change EEG brain functional connectivity?
(Source: Epilepsy Research)
Source: Epilepsy Research - July 28, 2016 Category: Neurology Authors: Fabrice Bartolomei, Francesca Bonini, Elsa Vidal, Agnes Tr ébuchon, Stanislas Lagarde, Isabelle Lambert, Aileen McGonigal, Didier Scavarda, Romain Carron, Christian G. Benar Source Type: research
The modulatory effect of nitric oxide in pro- and anti-convulsive effects of vasopressin in PTZ-induced seizures threshold in mice
(Source: Epilepsy Research)
Source: Epilepsy Research - July 28, 2016 Category: Neurology Authors: Nina Javadian, Nastaran Rahimi, Mehrak Javadi-Paydar, Amir Hossein Doustimotlagh, Ahmad Reza Dehpour Source Type: research
Glycyrrhizin ameliorates oxidative stress and inflammation in hippocampus and olfactory bulb in lithium/pilocarpine-induced status epilepticus in rats
(Source: Epilepsy Research)
Source: Epilepsy Research - July 28, 2016 Category: Neurology Authors: Susana Gonz ález-Reyes, Juan Jair Santillán-Cigales, Angélica Saraí Jiménez-Osorio, José Pedraza-Chaverri, Rosalinda Guevara-Guzmán Source Type: research
Compromised GABAergic inhibition contributes to tumor-associated epilepsy
Gliomas are the most common form of primary brain tumor and frequently present with seizures (Iuchi et al., 2015; Kerkhof and Vecht, 2013; van Breemen et al., 2007). The tumor mass itself does not show epileptiform activity, but rather seizures originate from neurons in the peritumoral region (Kohling et al., 2006; Patt et al., 2000; Senner et al., 2003). The standard treatment for glioma involves surgical resection; however, tumor associated epilepsy often persists following glioma removal (Iuchi et al., 2015). (Source: Epilepsy Research)
Source: Epilepsy Research - July 26, 2016 Category: Neurology Authors: Georgina MacKenzie, Kate K. O ’Toole, Jamie Maguire Source Type: research
Elevated expression of human papillomavirus antigen in brain tissue of patients with Rasmussen ’s encephalitis
Rasmussen ’s encephalitis (RE), which was first described by Rasmussen in 1958, is a rare, dispersed, and progressive neurological syndrome. It is characterized by unilateral inflammation of the cerebral cortex, focal epilepsy, progressive hemiplegia and cognitive deterioration (Rasmussen et al., 1958). Nea rly 50% of patients develop epilepsia partialis continua (EPC) within 1year after the onset of seizures. Anti-epilepsy drugs have little effect on focal seizures, and anti-inflammatory therapies, including pulse therapy with steroids or immune globulins, are only beneficial for partial RE patients o ver a short period...
Source: Epilepsy Research - July 26, 2016 Category: Neurology Authors: Shuai Chen, Sichang Chen, Yuguang Guan, Yao Zhang, Xueling Qi, Jing An, Yisong Wang, Guoming Luan Source Type: research
Elevated Expression of Human Papillomavirus Antigen in Brain Tissue of Patients with Rasmussen's Encephalitis
(Source: Epilepsy Research)
Source: Epilepsy Research - July 26, 2016 Category: Neurology Authors: Shuai Chen, Sichang Chen, Yuguang Guan, Yao Zhang, Xueling Qi, Jing An, Yisong Wang, Guoming Luan Source Type: research
Investigation of mechanisms of vagus nerve stimulation for seizure using finite element modeling
Vagus Nerve Stimulation (VNS) was FDA approved nearly 20 years ago in 1997, implanted in over 65,000 patients and yet its mechanisms of action in treating epileptic seizures remain unclear. While responder rates are over 50% for the 30 –40% of patients who are resistant to anti-seizure medications, most responders do not become seizure-free, but rather have the severity and frequency of seizures reduced by approximately 40–50% on average (Amar et al., 2009; Wu and Sharan, 2013). (Source: Epilepsy Research)
Source: Epilepsy Research - July 26, 2016 Category: Neurology Authors: Jeffrey E. Arle, Kristen W. Carlson, Longzhi Mei Source Type: research
Compromised GABAergic inhibition contributes to tumor-associated epilepsy.
(Source: Epilepsy Research)
Source: Epilepsy Research - July 26, 2016 Category: Neurology Authors: Georgina MacKenzie, Kate K. O ’Toole, Jamie Maguire Source Type: research
Incidence and localizing value of vertigo and dizziness in patients with epilepsy: Video-EEG monitoring study
Vertigo and dizziness are common neurological complaints with a lifetime prevalence of 20%-30% in the general population, and it accounts for approximately 3.5% of the patients who visited an emergency room (Crespi, 2004; Neuhauser et al., 2008). The differential diagnosis in patients with vertigo includes various peripheral causes, including benign paroxysmal positional vertigo, vestibular neuritis, and Meni ère disease, but several central causes should be considered, such as cerebrovascular diseases, vestibular migraine, and epilepsy-related vertigo, because the presence of central causes may be life-threatening and re...
Source: Epilepsy Research - July 14, 2016 Category: Neurology Authors: Dong Wook Kim, Jun-Sang Sunwoo, Sang Kun Lee Tags: Short communication Source Type: research
GC –MS–Based metabolomics discovers a shared serum metabolic characteristic among three types of epileptic seizures
As defined by the International League against Epilepsy (ILAE), epilepsy is defined as “a group of neurological disorders characterized by an enduring predisposition to generate epileptic seizures” (Fisher et al., 2014). Epilepsy, with high morbidity and a long duration, seriously threatens people’s health and quality of life. According to the WHO, there are approximately 50 mil lion epilepsy patients worldwide (Brodie et al., 1997), and more than 30% of all epilepsy patients cannot control their seizures with current medications (Kwan and Brodie, 2000). (Source: Epilepsy Research)
Source: Epilepsy Research - July 14, 2016 Category: Neurology Authors: Dian Wang, Xingxing Wang, Jing Kong, Jiayan Wu, Minchao Lai Source Type: research
Resection of ictal high frequency oscillations is associated with favorable surgical outcome in pediatric drug resistant epilepsy secondary to tuberous sclerosis complex
Tuberous sclerosis complex (TSC) is a congenital syndrome characterized by the widespread development of benign tumors in multiple organs (Pan et al., 2004). Epilepsy is observed in 60 –96% of individuals with TSC; 70% of children who develop epilepsy present with seizures in the first year of life (Cross, 2005). In addition, 50–80% of children with TSC and epilepsy may be drug resistant (Jansen et al., 2006). Epilepsy surgery, especially resective surgery, has been shown to d ecrease frequency or stop seizures in a subset of drug resistant epilepsy patients with TSC (Koh et al., 2000; Weiner et al., 2006). (Source: Epilepsy Research)
Source: Epilepsy Research - July 14, 2016 Category: Neurology Authors: Hisako Fujiwara, James L. Leach, Hansel M. Greiner, Katherine D. Holland-Bouley, Douglas F. Rose, Todd Arthur, Francesco T. Mangano Source Type: research
GC –MS–Based metabolomics discovers a shared serum metabolic characteristic among three types of epileptic seizures
As defined by the International League against Epilepsy (ILAE), epilepsy is defined as “a group of neurological disorders characterized by an enduring predisposition to generate epileptic seizures” (Fisher et al., 2014). Epilepsy, with high morbidity and a long duration, seriously threatens people’s health and quality of life. According to the WHO, there are approximately 50 mil lion epilepsy patients worldwide (Brodie et al., 1997), and more than 30% of all epilepsy patients cannot control their seizures with current medications (Kwan and Brodie, 2000). (Source: Epilepsy Research)
Source: Epilepsy Research - July 14, 2016 Category: Neurology Authors: Dian Wang, Xingxing Wang, Jing Kong, Jiayan Wu, Minchao Lai Source Type: research
