P38 MAPK Pathway Mediates Cognitive Damage in Pentylenetetrazole-Induced Epilepsy via Apoptosis Cascade
(Source: Epilepsy Research)
Source: Epilepsy Research - April 20, 2017 Category: Neurology Authors: Qi Huang, Xixia Liu, Yuan Wu, Yuhan Liao, Yiqing Huang, Xing Wei, Meigang Ma Source Type: research
Evaluation of GLUT1 variation in non-acquired focal epilepsy
(Source: Epilepsy Research)
Source: Epilepsy Research - April 10, 2017 Category: Neurology Authors: Alexander Peeraer, John A. Damiano, Susannah T. Bellows, Ingrid E. Scheffer, Samuel F. Berkovic, Saul A. Mullen, Michael S. Hildebrand Source Type: research
Investigating the correlation between short-term effectiveness of VNS Therapy in reducing the severity of seizures and long-term responsiveness
(Source: Epilepsy Research)
Source: Epilepsy Research - April 10, 2017 Category: Neurology Authors: Maryam Ravan Source Type: research
Reduced Abnormal Integration of Adult-Generated Granule Cells does not Attenuate Spontaneous Recurrent Seizures in Mice
Neurogenesis in the subgranular zone (SGZ) of the dentate gyrus (DG) persists throughout life in a wide variety of mammalian species. In rodent temporal lobe epilepsy (TLE) models, initial status epilepticus (SE) insult lead to augmented DG neurogenesis and abnormal integrations of newly generated granule cells, including hilar ectopic cells (HECs), hilar basal dendrites (HBDs) and mossy fiber sprouting (MFS), which potentially mediate the formation of hyperexcitable DG circuits (Parent et al., 1997; Murphy et al., 2011; Pun et al., 2012). (Source: Epilepsy Research)
Source: Epilepsy Research - April 10, 2017 Category: Neurology Authors: Kun Zhu, Bo Yuan, Ming Hu, Gai-Feng Feng, Yong Liu, Jian-Xin Liu Source Type: research
Refractory focal motor seizures controlled with intramuscular botulinum toxin
(Source: Epilepsy Research)
Source: Epilepsy Research - April 10, 2017 Category: Neurology Authors: Wei-I Lee, Patrick Carney, Andrew Hughes, John Archer Tags: Short communication Source Type: research
The ketogenic diet metabolite beta-hydroxybutyrate ( β-HB) reduces incidence of seizure-like activity (SLA) in a Katp- and GABAb-dependent manner in a whole-animal Drosophila melanogaster model
The ketogenic diet (KD) is a high-fat, low-carbohydrate dietary therapy featuring an elevated ratio (typically 4:1) of lipids to non-lipids (Wilder, 1921; Thiele, 2003). The KD is used effectively in the clinic to reduce drug-resistant seizures in cases of pediatric epilepsy (Thiele, 2003; Neal et al., 2008) and may be effective in treating adult cases of epilepsy as well (for example, see Lambrechts et al., 2012). The KD produces high levels of circulating ketone bodies (KB ’s), such as beta-hydroxybutyrate (β-HB) (Appleton and DeVivo, 1974; DeVivo et al., 1978), which may be used as fuel by the brain (Sokoloff, 1973) ...
Source: Epilepsy Research - April 5, 2017 Category: Neurology Authors: Jinglu Li, Emma I. O ’Leary, Geoffrey R. Tanner Tags: Short communication Source Type: research
Evaluating executive function in patients with temporal lobe epilepsy using the frontal assessment battery
Executive function or cognitive control is the ability to manage complex, goal-oriented thoughts and behaviors. A wide range of cognitive domains including attention, concept formation, inhibition control, mental flexibility, working memory, problem-solving and planning is required to attain this purpose (Diamond, 2013). Executive function is considered as a higher level of cognitive processing which is mainly dependent on frontal lobe function (Diamond, 2013). (Source: Epilepsy Research)
Source: Epilepsy Research - April 5, 2017 Category: Neurology Authors: Elmira Agah, Nasima Asgari-Rad, Mona Ahmadi, Abbas Tafakhori, Vajiheh Aghamollaii Source Type: research
Microstructural alterations of white matter in juvenile myoclonic epilepsy
(Source: Epilepsy Research)
Source: Epilepsy Research - April 4, 2017 Category: Neurology Authors: Jinnan Gong, Xuebin Chang, Sisi Jiang, Benjamin Klugah-Brown, Song Tan, Dezhong Yao, Cheng Luo Source Type: research
Structural brain changes in medically refractory focal epilepsy resemble premature brain aging
Medically refractory focal epilepsy is associated with decreased brain-wide volumetric measures and cognitive function, both of which are also observed in normal aging (Dabbs et al., 2012; Hoppe et al., 2007; Sowell et al., 2003; Salthouse, 2004). Prior studies have noted that epilepsy-related neuroanatomical and cognitive changes are greater than those observed in normal aging and therefore may be conceptualized as accelerated aging (Breuer et al., 2016; Lin et al., 2012; Bernhardt et al., 2009; Helmstaedter et al., 2003). (Source: Epilepsy Research)
Source: Epilepsy Research - April 3, 2017 Category: Neurology Authors: Heath R. Pardoe, James H. Cole, Karen Blackmon, Thomas Thesen, Ruben Kuzniecky, for the Human Epilepsy Project Investigators Source Type: research
Sporadic periventricular nodular heterotopia: Classification, phenotype and correlation with Filamin A mutations
Heterotopia is defined by the presence of groups of normal neurons in an inappropriate location, which results from a primary failure of neuronal migration, including periventricular, subcortical and leptomeningeal glioneuronal varieties (Barkovich et al., 2001; Barkovich et al., 2005; Barkovich et al., 2012; Guerrini and Barba, 2010). The most common clinical manifestations of heterotopia are epileptic seizures, mainly resistant focal seizures, neurological deficits, systemic malformations and developmental delays (Barkovich et al., 2012; Guerrini and Parrini, 2010). (Source: Epilepsy Research)
Source: Epilepsy Research - April 3, 2017 Category: Neurology Authors: Wenyu Liu, Bo Yan, Dongmei An, Jiahe Xiao, Fayun Hu, Dong Zhou Source Type: research
Personality traits of children before and after epilepsy surgery
(Source: Epilepsy Research)
Source: Epilepsy Research - April 3, 2017 Category: Neurology Authors: Olga Braams, Renske Schappin, Joost Meekes, Peter C. van Rijen, Onno van Nieuwenhuizen, Kees P. Braun, Aag Jennekens-Schinkel Tags: Short communication Source Type: research
Decrease of global current source density predicts successful treatment in absence and juvenile myoclonic epilepsies
(Source: Epilepsy Research)
Source: Epilepsy Research - April 2, 2017 Category: Neurology Authors: Johanna D ömötör, Béla Clemens, Szilvia Puskás, István Fekete Source Type: research
Long-term outcome of refractory status epilepticus in adults: A retrospective population-based study
(Source: Epilepsy Research)
Source: Epilepsy Research - April 2, 2017 Category: Neurology Authors: Anne-Mari Kantanen, Matti Reinikainen, Ilkka Parviainen, Reetta K älviäinen Source Type: research
Pharmacodynamics of remifentanil. Induced intracranial spike activity in mesial temporal lobe epilepsy
Recordings of electrical brain activity with EEG during epileptic seizures reveal abnormal cortical hypersynchronization. Between seizures the EEG often shows interictal depolarizing phenomena such as spikes generated by assemblies of hyperexcitable neurons. When interictal spikes appear in a part of cortex it is considered an irritative zone. Seizures arise from the seizure onset zone. Often these zones are in close spatial proximity (de Curtis and Avanzini, 2001). (Source: Epilepsy Research)
Source: Epilepsy Research - March 30, 2017 Category: Neurology Authors: Troels Wesenberg Kjaer, Hans Hogenhaven, Andrea P. Lee, Flemming Find Madsen, Bo Jespersen, Jannick Brennum, Lennart Derm, Finn Borgbjerg Moltke Source Type: research
Voxel-based analysis of diffusion tensor imaging in patients with mesial temporal lobe epilepsy
(Source: Epilepsy Research)
Source: Epilepsy Research - March 24, 2017 Category: Neurology Authors: Patr ícia Sanches, Elaine Keiko Fujisao, Aline M.S. Braga, Nathalia Raquel Cristaldo, Roberto dos Reis, Seizo Yamashita, Luiz Eduardo Betting Source Type: research
