Reduced Abnormal Integration of Adult-Generated Granule Cells does not Attenuate Spontaneous Recurrent Seizures in Mice

Neurogenesis in the subgranular zone (SGZ) of the dentate gyrus (DG) persists throughout life in a wide variety of mammalian species. In rodent temporal lobe epilepsy (TLE) models, initial status epilepticus (SE) insult lead to augmented DG neurogenesis and abnormal integrations of newly generated granule cells, including hilar ectopic cells (HECs), hilar basal dendrites (HBDs) and mossy fiber sprouting (MFS), which potentially mediate the formation of hyperexcitable DG circuits (Parent et al., 1997; Murphy et al., 2011; Pun et al., 2012).

Source: Epilepsy Research - April 10, 2017 Category: Neurology Authors: Kun Zhu, Bo Yuan, Ming Hu, Gai-Feng Feng, Yong Liu, Jian-Xin Liu Source Type: research