Pharmacodynamics of remifentanil. Induced intracranial spike activity in mesial temporal lobe epilepsy

Recordings of electrical brain activity with EEG during epileptic seizures reveal abnormal cortical hypersynchronization. Between seizures the EEG often shows interictal depolarizing phenomena such as spikes generated by assemblies of hyperexcitable neurons. When interictal spikes appear in a part of cortex it is considered an irritative zone. Seizures arise from the seizure onset zone. Often these zones are in close spatial proximity (de Curtis and Avanzini, 2001).

Source: Epilepsy Research - March 30, 2017 Category: Neurology Authors: Troels Wesenberg Kjaer, Hans Hogenhaven, Andrea P. Lee, Flemming Find Madsen, Bo Jespersen, Jannick Brennum, Lennart Derm, Finn Borgbjerg Moltke Source Type: research