Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment
Epilepsy is a common neurological disorder that affects at least 50 million people worldwide (Loscher and Schmidt, 2002). Despite recent developments of anti-epileptic drugs and innovative approaches in the epilepsy treatment (Loscher et al., 2013) 30% of patients with temporal lobe epilepsy (TLE) still are unable to have their seizures controlled as a consequence of pharmacoresistance (McKeown and McNamara, 2001) and also do not meet the criteria for surgical intervention (Centeno et al., 2006). (Source: Epilepsy Research)
Source: Epilepsy Research - June 26, 2016 Category: Neurology Authors: Josy Carolina C. Pontes, Thiago Z. Lima, Claudio M. Queiroz, Simone M. Cinini, Miriam M. Blanco, Luiz E. Mello Source Type: research
Increased inhibitory synaptic activity in the hippocampus (ca1) of genetic absence epilepsy rats: relevance of kindling resistance
(Source: Epilepsy Research)
Source: Epilepsy Research - June 26, 2016 Category: Neurology Authors: Nihan Çarçak, Ergin Dileköz, Rezzan Gülhan, Rüştü Onur, Filiz Yılmaz Onat, Yıldırım Sara Source Type: research
Sleep respiratory parameters in children with idiopathic epilepsy: a cross-sectional study
(Source: Epilepsy Research)
Source: Epilepsy Research - June 26, 2016 Category: Neurology Authors: Maria Gogou, Katerina Haidopoulou, Maria Eboriadou, Efterpi Pavlidou, Maria Hatzistylianou, Evaggelos Pavlou Source Type: research
Effect of low frequency stimulation on impaired spontaneous alternation behavior of kindled rats in Y-maze test
Epilepsy is known as a common neurological disease which is characterized by repeated spontaneous seizures. In addition to recurrent seizures, patients with epilepsy frequently exhibit cognitive impairments, particularly in learning and memory related functions (Helmstaedter et al., 2003; Elger et al., 2004). (Source: Epilepsy Research)
Source: Epilepsy Research - June 25, 2016 Category: Neurology Authors: Samireh Ghafouri, Yaghoub Fathollahi, Mohammad Javan, Amir Shojaei, Azam Asgari, Javad Mirnajafi-Zadeh Source Type: research
Altered expression of neuronal CCR6 during pilocarpine induced status epilepticus in mice
Chemokine ligand-receptor family is originally described as chemotactic cytokines which are involved in leukocyte trafficking. Based on the position of cysteine residues, chemokines are classified into four groups, i.e., CXC ( α), CC (β), C (γ) and CX3C (δ), and the respective receptors are therefore named as CXCR, CCR, CR and CX3CR. While most chemokine ligand-receptors are only inductively expressed in neurons of central nervous system (CNS) in different animal models of neurological disorders, the constitutive expr ession of several chemokine ligand and/or receptors such as CCR1 (Meucci et al., 1998), CCL2/CCR2 (For...
Source: Epilepsy Research - June 25, 2016 Category: Neurology Authors: Jian-Xin Liu, Xia Cao, Yong Liu, Feng-Ru Tang Source Type: research
Fasting time duration modulates the onset of insulin-induced hypoglycemic seizures in mice
(Source: Epilepsy Research)
Source: Epilepsy Research - June 25, 2016 Category: Neurology Authors: Vigneshwaran Pitchaimani, Somasundaram Arumugam, Rajarajan Amirthalingam Thandavarayan, Vengadeshprabhu Karuppagounder, Mst. Rejina Afrin, Remya Sreedhar, Meilei Harima, Hiroshi Suzuki, Shizuka Miyashita, Takashi Nakamura, Kenji Suzuki, Masahiko Nakamura, Source Type: research
Effect of low frequency stimulation on impaired spontaneous alternation behavior of kindled rats in Y-maze test
(Source: Epilepsy Research)
Source: Epilepsy Research - June 25, 2016 Category: Neurology Authors: Samireh Ghafouri, Yaghoub Fathollahi, Mohammad Javan, Amir Shojaei, Azam Asgari, Javad Mirnajafi-Zadeh Source Type: research
Altered Expression of Neuronal CCR6 During Pilocarpine Induced Status Epilepticus in Mice
(Source: Epilepsy Research)
Source: Epilepsy Research - June 25, 2016 Category: Neurology Authors: Jian-Xin Liu, Xia Cao, Yong Liu, Feng-Ru Tang Source Type: research
T2 relaxometry improves detection of non-sclerotic epileptogenic hippocampus
Temporal lobe epilepsy (TLE) is the most common type of focal epilepsy in adults that can be successfully treated by surgery. Hippocampal sclerosis (HS) is the main pathology of TLE, and is characterized by atrophy and increased T2 signal intensity on magnetic resonance (MR) imaging. Hippocampal volume is correlated with neuron cell count (Briellmann et al., 2002; Van Paesschen et al., 1997). Quantification of hippocampal volume on MR imaging can be useful to detect HS and to identify the epileptogenic side (Jack et al., 1990). (Source: Epilepsy Research)
Source: Epilepsy Research - June 24, 2016 Category: Neurology Authors: Shiho Sato, Masaki Iwasaki, Hiroyoshi Suzuki, Shunji Mugikura, Kazutaka Jin, Teiji Tominaga, Kei Takase, Shoki Takahashi, Nobukazu Nakasato Source Type: research
Magnetoencephalography-guided surgery in frontal lobe epilepsy using neuronavigation and intraoperative MR imaging
Approximately 25 –40% of patients with epilepsy suffer from drug-resistant seizures. Besides the disabling occurrence of seizures, patients experience cognitive impairment, reduced quality of life, increased mortality and permanent neurological deficits when not treated surgically (Laxer et al., 2014). Following t emporal lobe epilepsy, frontal lobe epilepsy (FLE) is the second most common type of drug-resistant epilepsy that is encountered. Approximately 20% of all patients with epilepsy suffer from frontal lobe seizures (Lee et al., 2008; Pondal-Sordo et al., 2006). (Source: Epilepsy Research)
Source: Epilepsy Research - June 24, 2016 Category: Neurology Authors: Bj örn Sommer, Karl Roessler, Stefan Rampp, Hajo M. Hamer, Ingmar Blumcke, Hermann Stefan, Michael Buchfelder Source Type: research
Effect of a single dose of retigabine in cortical excitability parameters: A cross-over, double-blind placebo-controlled TMS study
Epilepsy is a devastating medical condition with many psychosocial implications. According to the World Health Organization (WHO), it affects more than 50 million people worldwide (WHO Epilepsy, 2016). The annual cost of epilepsy in Europe was estimated as €15.5 billion in 2004 (Pugliatti et al., 2007). (Source: Epilepsy Research)
Source: Epilepsy Research - June 24, 2016 Category: Neurology Authors: Michel Ossemann, Katalin de Fays, Benoit Bihin, Yves Vandermeeren Source Type: research
T2 relaxometry improves detection of non-sclerotic epileptogenic hippocampus
(Source: Epilepsy Research)
Source: Epilepsy Research - June 24, 2016 Category: Neurology Authors: Shiho Sato, Masaki Iwasaki, Hiroyoshi Suzuki, Shunji Mugikura, Kazutaka Jin, Teiji Tominaga, Kei Takase, Shoki Takahashi, Nobukazu Nakasato Source Type: research
Magnetoencephalography-guided surgery in frontal lobe epilepsy using neuronavigation and intraoperative MR imaging
(Source: Epilepsy Research)
Source: Epilepsy Research - June 24, 2016 Category: Neurology Authors: Björn Sommer, Karl Roessler, Stefan Rampp, Hajo M. Hamer, Ingmar Blumcke, Hermann Stefan, Michael Buchfelder Source Type: research
Effect of a single dose of retigabine in cortical excitability parameters: A cross-over, double-blind placebo-controlled TMS study
(Source: Epilepsy Research)
Source: Epilepsy Research - June 24, 2016 Category: Neurology Authors: Michel Ossemann, Katalin de Fays, Benoit Bihin, Yves Vandermeeren Source Type: research
Ictal unilateral blinking is an unreliable lateralizing sign in tuberous sclerosis complex
(Source: Epilepsy Research)
Source: Epilepsy Research - June 24, 2016 Category: Neurology Authors: Trupti Jadhav, Catherine Bailey, Wirginia Maixner, A.Simon Harvey Tags: Short communication Source Type: research
