Altered expression of neuronal CCR6 during pilocarpine induced status epilepticus in mice

Chemokine ligand-receptor family is originally described as chemotactic cytokines which are involved in leukocyte trafficking. Based on the position of cysteine residues, chemokines are classified into four groups, i.e., CXC ( α), CC (β), C (γ) and CX3C (δ), and the respective receptors are therefore named as CXCR, CCR, CR and CX3CR. While most chemokine ligand-receptors are only inductively expressed in neurons of central nervous system (CNS) in different animal models of neurological disorders, the constitutive expr ession of several chemokine ligand and/or receptors such as CCR1 (Meucci et al., 1998), CCL2/CCR2 (Foresti et al., 2009; Arisi et al., 2015), CCL3/CCR3 (Cowell and Silverstein, 2003; Xu et al., 2009), CXCR4 (for review, see Nash and Meucci 2014), CCR7, CCR8, CCR9, CCL28/CCR10 (Liu et al., 2007, 2012 ) have also been reported.

Source: Epilepsy Research - June 25, 2016 Category: Neurology Authors: Jian-Xin Liu, Xia Cao, Yong Liu, Feng-Ru Tang Source Type: research