Population pharmacokinetics and dose-response relationship of levetiracetam in adult patients with epilepsy
(Source: Epilepsy Research)
Source: Epilepsy Research - February 27, 2017 Category: Neurology Authors: Su-Jin Rhee, Jung-Won Shin, Seung Hwan Lee, Jangsup Moon, Tae-Joon Kim, Ki-Young Jung, Kyung-Il Park, Soon-Tae Lee, Keun-Hwa Jung, Kyung-Sang Yu, In-Jin Jang, Kon Chu, Sang Kun Lee Source Type: research
Paroxysmal Nonepileptic Events in Children with Epilepsy
(Source: Epilepsy Research)
Source: Epilepsy Research - February 27, 2017 Category: Neurology Authors: Yuji Ito, Hiroyuki Kidokoro, Tamiko Negoro, Masaharu Tanaka, Yu Okai, Yoko Sakaguchi, Chikako Ogawa, Tomoya Takeuchi, Atsuko Ohno, Hiroyuki Yamamoto, Tomohiko Nakata, Satoshi Maesawa, Kazuyoshi Watanabe, Yoshiyuki Takahashi, Jun Natsume Source Type: research
Association of CYP2C9, CYP2A6, ACSM2A, and CPT1A gene polymorphisms with adverse effects of valproic acid in Chinese patients with epilepsy
VPA is a branched short-chain fatty acid that is widely used as a first-line antiepileptic drug. Because of its narrow therapeutic concentration (50 –100μgmL−1), therapeutic drug monitoring is common. There are at least three routes of VPA metabolism in humans: β-oxidation in the mitochondria, cytochrome P450(CYP)-mediated oxidation of phase I and glucuronidation of phase II. Hepatotoxicity is the most serious adverse reaction to VPA. The current understanding of VPA hepatotoxicity involves VPA and its unsaturated metabolite 4-ene-VPA, which is activated by ligation to fatty acyl coenzyme A (CoA) via the medium chain...
Source: Epilepsy Research - February 27, 2017 Category: Neurology Authors: Can Wang, Ping Wang, Li-ping Yang, Jing Pan, Xue Yang, Hong-ying Ma Source Type: research
Decreased Health Care Utilization and Health Care Costs in the Inpatient and Emergency Department Setting Following Initiation of Ketogenic Diet in Pediatric Patients: The Experience in Ontario, Canada
(Source: Epilepsy Research)
Source: Epilepsy Research - February 17, 2017 Category: Neurology Authors: Sharon Whiting, Elizabeth Donner, Rajesh RamachandranNair, Jennifer Grabowski, Nathalie Jett é, Daniel Rodriguez Duque Source Type: research
Efficacy of a ketogenic diet in resistant myoclono-astatic epilepsy: A French multicenter retrospective study
(Source: Epilepsy Research)
Source: Epilepsy Research - February 15, 2017 Category: Neurology Authors: Elodie Stenger, Mickael Schaeffer, Claude Cances, Jacques Motte, St éphane Auvin, Dorothée Ville, Hélène Maurey, Rima Nabbout, Anne de Saint-Martin Source Type: research
Panayiotopoulos syndrome with a special emphasis of ictal semiologic features
(Source: Epilepsy Research)
Source: Epilepsy Research - February 15, 2017 Category: Neurology Authors: A. Destina Yal çın, Hülya Ertaşoğlu Toydemir Source Type: research
Clinical Correlation and Prognostic Implication of Periodic EEG Patterns: A Cohort Study
(Source: Epilepsy Research)
Source: Epilepsy Research - February 12, 2017 Category: Neurology Authors: Han-Tao Li, Tony Wu, Wey-Ran Lin, Wei-En Johnny Tseng, Chun-Wei Chang, Mei-Yun Cheng, Hsiang-Yao Hsieh, Hsing-I Chiang, Chih-Hong Lee, Bao-Luen Chang, Siew-Na Lim Source Type: research
Magnetic facial nerve stimulation in animal models of active seizure
We are developing a non-invasive facial nerve stimulator device as an emergency treatment for ischemic stroke. It is well-known that electric stimulation of the parasympathetic petrosal components of the facial nerve causes dilation of the cranial arteries and an increase in cerebral blood flow in normal animals (Forbes et al., 1937, 1939; Meyer et al., 1967; Adams et al., 1989; Goadsby, 1989, 1990a,b, 1991; Goadsby and Hoskin, 1994; Sato et al., 1997; Toda et al., 2000a,b) and in animals with brain ischemia (Yarnitsky et al., 2005, 2006; Henninger and Fisher, 2007; Takahashi et al., 2011). (Source: Epilepsy Research)
Source: Epilepsy Research - February 7, 2017 Category: Neurology Authors: Mark K. Borsody, Andrea Garcia, Dawn M. Bielawski, Chisa Yamada, Emilio Sacristan Source Type: research
Nonsteroidal anti-inflammatory drugs in clinical and experimental epilepsy
Epilepsy affects 50 million people worldwide according to the World Health Organization and 20 –30% of patients develop resistance to antiepileptic drugs. The side effects of antiepileptic treatments represent a heavy economic burden (de Kinderen et al., 2014) and have a significantly negative impact on the quality of life (Luoni et al., 2011). (Source: Epilepsy Research)
Source: Epilepsy Research - February 7, 2017 Category: Neurology Authors: Beatrice Mihaela Radu, Florin Bogdan Epureanu, Mihai Radu, Paolo Francesco Fabene, Giuseppe Bertini Tags: Review article Source Type: research
Real-world utility of whole exome sequencing with targeted gene analysis for focal epilepsy
(Source: Epilepsy Research)
Source: Epilepsy Research - February 5, 2017 Category: Neurology Authors: Piero Perucca, Ingrid E. Scheffer, A. Simon Harvey, Paul A. James, Sebastian Lunke, Natalie Thorne, Clara Gaff, Brigid M. Regan, John A. Damiano, Michael S. Hildebrand, Samuel F. Berkovic, Terence J. O ’Brien, Patrick Kwan Source Type: research
SCN1A clinical spectrum includes the self-limited focal epilepsies of childhood
SCN1A is arguably the most important epilepsy gene with vast clinical heterogeneity. Not only can different SCN1A variants result in variable epilepsy phenotypes, but the same variant, even within the one family, can result in very different clinical outcomes. We see no clearer example of this than in families with genetic epilepsy with febrile seizures plus (GEFS+). (Source: Epilepsy Research)
Source: Epilepsy Research - February 3, 2017 Category: Neurology Authors: Sara Kivity, Karen L. Oliver, Zaid Afawi, John A. Damiano, Todor Arsov, Melanie Bahlo, Samuel F. Berkovic Source Type: research
Utility of gray-matter segmentation of ictal-Interictal perfusion SPECT and interictal 18F-FDG-PET in medically refractory epilepsy
Epilepsy, or recurrent unprovoked seizures, is estimated to affect 50 million people worldwide with an incidence of 44 per 100,000 person-years (Hauser et al., 1993). Twenty-nine percent of people with epilepsy are considered to have medically refractory epilepsy, which is associated with poor quality of life and increased morbidity and mortality (Kwan and Brodie, 2000; Lee et al., 2005; Shandal et al., 2012). (Source: Epilepsy Research)
Source: Epilepsy Research - January 29, 2017 Category: Neurology Authors: Kathryn C. Elkins, Valeria M. Moncayo, Hyunmi Kim, Larry D. Olson Tags: Research paper Source Type: research
Reduced thalamic volume in patients with Electrical Status Epilepticus in Sleep
(Source: Epilepsy Research)
Source: Epilepsy Research - January 26, 2017 Category: Neurology Authors: Iv án Sánchez Fernández, Jurriaan M. Peters, Alireza Akhondi-Asl, Jacquelyn Klehm, Simon K. Warfield, Tobias Loddenkemper Source Type: research
Prognostic factors in patients with refractory idiopathic generalized epilepsy
(Source: Epilepsy Research)
Source: Epilepsy Research - January 26, 2017 Category: Neurology Authors: A. Gomez-Iba ñez, R.S. McLachlan, S.M. Mirsattari, D.C. Diosy, J.G. Burneo Source Type: research
Development and validation of AIIMS modified INCLEN diagnostic instrument for epilepsy in children aged 1month to 18 years
(Source: Epilepsy Research)
Source: Epilepsy Research - January 24, 2017 Category: Neurology Authors: Sheffali Gulati, Harsh Patel, Biswaroop Chakrabarty, Rachana Dubey, N.K. Arora, R.M. Pandey, V.K. Paul, Konanki Ramesh, Vyshakh Anand, Ankit Meena Source Type: research
