Resection of ictal high frequency oscillations is associated with favorable surgical outcome in pediatric drug resistant epilepsy secondary to tuberous sclerosis complex
Tuberous sclerosis complex (TSC) is a congenital syndrome characterized by the widespread development of benign tumors in multiple organs (Pan et al., 2004). Epilepsy is observed in 60–96% of individuals with TSC; 70% of children who develop epilepsy present with seizures in the first year of life (Cross, 2005). In addition, 50–80% of children with TSC and epilepsy may be drug resistant (Jansen et al., 2006). Epilepsy surgery, especially resective surgery, has been shown to decrease frequency or stop seizures in a subset of drug resistant epilepsy patients with TSC (Koh et al., 2000; Weiner et al., 2006). (Source: Epilepsy Research)
Source: Epilepsy Research - July 14, 2016 Category: Neurology Authors: Hisako Fujiwara, James L. Leach, Hansel M. Greiner, Katherine D. Holland-Bouley, Douglas F. Rose, Todd Arthur, Francesco T. Mangano Source Type: research
Incidence and Localizing Value of Vertigo and Dizziness in Patients with Epilepsy: Video-EEG monitoring study
(Source: Epilepsy Research)
Source: Epilepsy Research - July 14, 2016 Category: Neurology Authors: Dong Wook Kim, Jun-Sang Sunwoo, Sang Kun Lee Tags: Short communication Source Type: research
GC–MS–Based Metabolomics Discovers a Shared Serum Metabolic Characteristic Among Three Types of Epileptic Seizures
(Source: Epilepsy Research)
Source: Epilepsy Research - July 14, 2016 Category: Neurology Authors: Dian Wang, Xingxing Wang, Jing Kong, Jiayan Wu, Minchao Lai Source Type: research
Resection of ictal high frequency oscillations is associated with improved surgical outcome in pediatric drug resistant epilepsy secondary to tuberous sclerosis complex
(Source: Epilepsy Research)
Source: Epilepsy Research - July 14, 2016 Category: Neurology Authors: Hisako Fujiwara, James L. Leach, Hansel M. Greiner, Katherine D. Holland-Bouley, Douglas F. Rose, Todd Arthur, Francesco T. Mangano Source Type: research
Interactions between non-vitamin K oral anticoagulants and antiepileptic drugs
Atrial fibrillation (AF) is one of the most frequent causes of stroke. Secondary prophylaxis by oral anticoagulants (OACs) is recommended after stroke in patients with AF. For decades, vitamin-K antagonists (VKAs) were the only available drugs for OAC. In the last years, non-vitamin K antagonist oral anticoagulants (NOACs) like dabigatran, rivaroxaban, apixaban or edoxaban have been introduced as OAC drugs for patients with AF or venous thromboembolism, based on large randomized trials, and their use is recommended by various guidelines. (Source: Epilepsy Research)
Source: Epilepsy Research - July 7, 2016 Category: Neurology Authors: Claudia St öllberger, Josef Finsterer Tags: Short communication Source Type: research
Interactions between non-vitamin K oral anticoagulants and antiepileptic drugs
(Source: Epilepsy Research)
Source: Epilepsy Research - July 7, 2016 Category: Neurology Authors: Claudia Stöllberger, Josef Finsterer Tags: Short communication Source Type: research
Functional brain network alterations in epilepsy: A magnetoencephalography study
Epilepsy is a neurological disorder characterized by recurrent seizure, which affects more than 50 million people worldwide, according to the World Health Organization (Niso et al., 2015). During the seizures there is abnormal excessive firing of neurons in the brain resulting in diverse symptoms such as staring, muscle stiffness, muscle spasms and impaired consciousness (van Mierlo et al., 2014). The gradual process by which a normal neural network changes into a hyperexcitable one leading to epilepsy is known as epileptogenesis. (Source: Epilepsy Research)
Source: Epilepsy Research - July 6, 2016 Category: Neurology Authors: Beilei Wang, Lu Meng Source Type: research
Functional Brain Network Alterations in Epilepsy: A Magnetoencephalography Study
(Source: Epilepsy Research)
Source: Epilepsy Research - July 6, 2016 Category: Neurology Authors: Wang Beilei, Lu Meng Source Type: research
Increased MRI volumetric correlation contralateral to seizure focus in temporal lobe epilepsy
Temporal lobe epilepsy (TLE) is a common form of epilepsy occurring in adults and is characterized by recurrent temporolimbic seizure activity (Berg et al., 2003; Engel, 2001). A neuropathological hallmark of TLE is atrophy of the epileptogenic (ipsilateral) hippocampus as can be determined from anatomical MRI (Mathern et al., 1995). Volumetric group difference studies employing voxel based morphometry (Ashburner and Friston, 2000) (VBM) have demonstrated widespread gray matter atrophy in TLE compared to healthy controls including hippocampus, neighboring medial temporal, bilateral thalamus, prefrontal, and parietal region...
Source: Epilepsy Research - July 3, 2016 Category: Neurology Authors: Benjamin N. Conrad, Baxter P. Rogers, Bassel Abou-Khalil, Victoria L. Morgan Source Type: research
Increased MRI volumetric correlation contralateral to seizure focus in temporal lobe epilepsy
(Source: Epilepsy Research)
Source: Epilepsy Research - July 3, 2016 Category: Neurology Authors: Benjamin N. Conrad, Baxter P. Rogers, Bassel Abou-Khalil, Victoria L. Morgan Source Type: research
Usefulness of repeat review of head magnetic resonance images during presurgical epilepsy conferences
For medically intractable focal epilepsy, typically defined as a focal epilepsy that has proven intractable to 2 or more appropriately chosen and dosed anticonvulsants (Kwan et al., 2010), resective epilepsy surgery of the epileptogenic lesion has become the standard of care in select patients because of its superior efficacy (Dlugos, 2001; Engel et al., 2012; Jobst and Cascino, 2015; Paolicchi et al., 2000). In many institutions, patients are presented at a presurgical conference to solicit opinions from neurologists and neurosurgeons and also from neuroradiologists, neuropsychologists, and other providers. (Source: Epilepsy Research)
Source: Epilepsy Research - June 30, 2016 Category: Neurology Authors: Daniel L. Kenney, Kristen M. Kelly-Williams, Karl N. Krecke, Robert J. Witte, Robert E. Watson, Amy L. Kotsenas, Elaine C. Wirrell, Katherine C. Nickels, Lily C. Wong-Kisiel, Elson So Tags: Short communication Source Type: research
Usefulness of Repeat Review of Head Magnetic Resonance Images During Presurgical Epilepsy Conferences
(Source: Epilepsy Research)
Source: Epilepsy Research - June 30, 2016 Category: Neurology Authors: Daniel L. Kenney, Kristen M. Kelly-Williams, Karl N. Krecke, Robert J. Witte, Robert E. Watson, Amy L. Kotsenas, Elaine C. Wirrell, Katherine C. Nickels, Lily C. Wong-Kisiel, Elson So Tags: Short communication Source Type: research
Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment
Epilepsy is a common neurological disorder that affects at least 50 million people worldwide (Loscher and Schmidt, 2002). Despite recent developments of anti-epileptic drugs and innovative approaches in the epilepsy treatment (Loscher et al., 2013) 30% of patients with temporal lobe epilepsy (TLE) still are unable to have their seizures controlled as a consequence of pharmacoresistance (McKeown and McNamara, 2001) and also do not meet the criteria for surgical intervention (Centeno et al., 2006). (Source: Epilepsy Research)
Source: Epilepsy Research - June 26, 2016 Category: Neurology Authors: Josy Carolina C. Pontes, Thiago Z. Lima, Claudio M. Queiroz, Simone M. Cinini, Miriam M. Blanco, Luiz E. Mello Source Type: research
Increased inhibitory synaptic activity in the hippocampus (CA1) of genetic absence epilepsy rats: Relevance of kindling resistance
Typical absence epilepsy is manifested as a transient impaired awareness and/or a brief interruption in the ongoing activity, together with a simultaneous, time-locked electroencephalogram (EEG) finding of bilateral, synchronous, and symmetrical spike-and-wave discharges (SWDs) (Panayiotopoulos et al., 1989, 1992). A crucial role for the mutually interconnected circuitry of the cortex and the thalamus has been well recognized in the generation of the characteristic SWDs in human absence epilepsy and many animal models (Avanzini et al., 1996; Crunelli and Leresche, 2002; Gloor et al., 1990; Snead, 1995). (Source: Epilepsy Research)
Source: Epilepsy Research - June 26, 2016 Category: Neurology Authors: Nihan Çarçak, Ergin Dileköz, Rezzan Gülhan, Rüştü Onur, Filiz Yılmaz Onat, Yıldırım Sara Source Type: research
Sleep respiratory parameters in children with idiopathic epilepsy: A cross-sectional study
Sleep co morbidities have been increasingly studied in patients with epilepsy and are thought to have a negative impact on life quality and disease course in this population (Dhamija et al., 2014; Grigg-Damberger and Ralls, 2014). According to sleep questionnaire studies, sleep breathing disorders (SBD) are one of the most frequently reported sleep problems among patients with epilepsy (Ong et al., 2009; Ruangkana et al., 2014). (Source: Epilepsy Research)
Source: Epilepsy Research - June 26, 2016 Category: Neurology Authors: Maria Gogou, Katerina Haidopoulou, Maria Eboriadou, Efterpi Pavlidou, Maria Hatzistylianou, Evaggelos Pavlou Source Type: research
