Increased MRI volumetric correlation contralateral to seizure focus in temporal lobe epilepsy

Temporal lobe epilepsy (TLE) is a common form of epilepsy occurring in adults and is characterized by recurrent temporolimbic seizure activity (Berg et al., 2003; Engel, 2001). A neuropathological hallmark of TLE is atrophy of the epileptogenic (ipsilateral) hippocampus as can be determined from anatomical MRI (Mathern et al., 1995). Volumetric group difference studies employing voxel based morphometry (Ashburner and Friston, 2000) (VBM) have demonstrated widespread gray matter atrophy in TLE compared to healthy controls including hippocampus, neighboring medial temporal, bilateral thalamus, prefrontal, and parietal regions (Bernasconi et al., 2004; Bonilha et al., 2004; Keller et al., 2002b).

Source: Epilepsy Research - July 3, 2016 Category: Neurology Authors: Benjamin N. Conrad, Baxter P. Rogers, Bassel Abou-Khalil, Victoria L. Morgan Source Type: research