Resection of ictal high frequency oscillations is associated with favorable surgical outcome in pediatric drug resistant epilepsy secondary to tuberous sclerosis complex

Tuberous sclerosis complex (TSC) is a congenital syndrome characterized by the widespread development of benign tumors in multiple organs (Pan et al., 2004). Epilepsy is observed in 60–96% of individuals with TSC; 70% of children who develop epilepsy present with seizures in the first year of life (Cross, 2005). In addition, 50–80% of children with TSC and epilepsy may be drug resistant (Jansen et al., 2006). Epilepsy surgery, especially resective surgery, has been shown to decrease frequency or stop seizures in a subset of drug resistant epilepsy patients with TSC (Koh et al., 2000; Weiner et al., 2006).

Source: Epilepsy Research - July 14, 2016 Category: Neurology Authors: Hisako Fujiwara, James L. Leach, Hansel M. Greiner, Katherine D. Holland-Bouley, Douglas F. Rose, Todd Arthur, Francesco T. Mangano Source Type: research