Increased inhibitory synaptic activity in the hippocampus (CA1) of genetic absence epilepsy rats: Relevance of kindling resistance

Typical absence epilepsy is manifested as a transient impaired awareness and/or a brief interruption in the ongoing activity, together with a simultaneous, time-locked electroencephalogram (EEG) finding of bilateral, synchronous, and symmetrical spike-and-wave discharges (SWDs) (Panayiotopoulos et al., 1989, 1992). A crucial role for the mutually interconnected circuitry of the cortex and the thalamus has been well recognized in the generation of the characteristic SWDs in human absence epilepsy and many animal models (Avanzini et al., 1996; Crunelli and Leresche, 2002; Gloor et al., 1990; Snead, 1995).

Source: Epilepsy Research - June 26, 2016 Category: Neurology Authors: Nihan Çarçak, Ergin Dileköz, Rezzan Gülhan, Rüştü Onur, Filiz Yılmaz Onat, Yıldırım Sara Source Type: research